{"id":"https://openalex.org/W2005489242","doi":"https://doi.org/10.5339/qfarf.2012.bmp95","title":"Identification of molecular pathways implicated in the metastasis process in a mouse model of lung adenocarcinoma","display_name":"Identification of molecular pathways implicated in the metastasis process in a mouse model of lung adenocarcinoma","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2005489242","doi":"https://doi.org/10.5339/qfarf.2012.bmp95","mag":"2005489242"},"language":"en","primary_location":{"id":"doi:10.5339/qfarf.2012.bmp95","doi":"https://doi.org/10.5339/qfarf.2012.bmp95","is_oa":false,"landing_page_url":"https://doi.org/10.5339/qfarf.2012.bmp95","pdf_url":null,"source":{"id":"https://openalex.org/S4306525077","display_name":"Qatar Foundation Annual Research Forum Volume 2012 Issue 1","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Qatar Foundation Annual Research Forum Volume 2012 Issue 1","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059797020","display_name":"Mouaadh Abdelkarim","orcid":"https://orcid.org/0000-0003-3538-2566","observed_orcids":["https://orcid.org/0000-0003-3538-2566"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Mouaadh Abdelkarim","raw_affiliation_strings":["Weill Cornell Medical College in Qatar, Doha, QATAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College in Qatar, Doha, QATAR","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052617903","display_name":"Supria Gerardine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Supria Gerardine","raw_affiliation_strings":["Weill Cornell Medical College in Qatar, Doha, QATAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College in Qatar, Doha, QATAR","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003490434","display_name":"Rufayda Marmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Rufayda Marmar","raw_affiliation_strings":["Weill Cornell Medical College in Qatar, Doha, QATAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College in Qatar, Doha, QATAR","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082363786","display_name":"Omar Kallas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Omar Kallas","raw_affiliation_strings":["Weill Cornell Medical College in Qatar, Doha, QATAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College in Qatar, Doha, QATAR","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010145003","display_name":"Hamid Massaeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Hamid Massaeli","raw_affiliation_strings":["Weill Cornell Medical College in Qatar, Doha, QATAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College in Qatar, Doha, QATAR","institution_ids":["https://openalex.org/I4210152471"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051559153","display_name":"Nasrin Mesaeli","orcid":"https://orcid.org/0000-0003-1456-4643","observed_orcids":["https://orcid.org/0000-0003-1456-4643"]},"institutions":[{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Nasrin Mesaeli","raw_affiliation_strings":["Weill Cornell Medical College in Qatar, Doha, QATAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College in Qatar, Doha, QATAR","institution_ids":["https://openalex.org/I4210152471"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210152471"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07445708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7368000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.10530000180006027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tie2-promoter","display_name":"Tie2 promoter","score":0.4880000054836273},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.9929999709129333},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.847000002861023},{"id":"https://openalex.org/keywords/vegf-signaling","display_name":"VEGF signaling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/tight-junction-signaling","display_name":"tight junction signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6966996192932129},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6413111090660095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6234363913536072},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6034560799598694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5503513216972351},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5292021036148071},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32106512784957886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30755579471588135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15143579244613647}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5339/qfarf.2012.bmp95","doi":"https://doi.org/10.5339/qfarf.2012.bmp95","is_oa":false,"landing_page_url":"https://doi.org/10.5339/qfarf.2012.bmp95","pdf_url":null,"source":{"id":"https://openalex.org/S4306525077","display_name":"Qatar Foundation Annual Research Forum Volume 2012 Issue 1","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Qatar Foundation Annual Research Forum Volume 2012 Issue 1","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981696006","https://openalex.org/W2064573700","https://openalex.org/W2554284703","https://openalex.org/W2967366602","https://openalex.org/W2376385980","https://openalex.org/W2075817938","https://openalex.org/W1496498748","https://openalex.org/W1997032381","https://openalex.org/W1979593122","https://openalex.org/W2287922696"],"abstract_inverted_index":{"A":[0],"global":[1],"survey":[2],"of":[3,15,39,42,81,97,102,108,118,133,147,253,268,320,334,336],"cancer":[4,9,18,21,52,56,72,83,222,274],"has":[5],"shown":[6],"that":[7,50,170,180,202,236,260,304],"lung":[8,51,82,110,134,148],"is":[10,105,307,315,327],"the":[11,16,58,74,79,95,106,119,125,130,203,237,266,318,331],"most":[12],"common":[13],"cause":[14],"new":[17],"cases":[19],"and":[20,26,53,144,154,160,168,185,213,228,246,249,284,323,349],"deaths":[22],"in":[23,61,69,129,173,208,242,265,273,294,317,338],"both":[24],"men":[25,62],"women":[27,70],"worldiwide.":[28],"In":[29,299],"Qatar":[30],"a":[31,37,88],"recent":[32],"retrospective":[33],"study":[34,78,121],"based":[35],"on":[36],"cohort":[38],"patient":[40],"registry":[41],"Al":[43],"Amal":[44],"Cancer":[45],"Hospital":[46],"from":[47,152,278],"1991-2006,":[48],"showed":[49],"lumph":[54],"node":[55],"are":[57,171,183,188,206,263,289],"major":[59],"cancers":[60],"(5.9%,":[63],"incident":[64],"rate":[65],"per":[66],"100,000)":[67],"while":[68],"breast":[71],"had":[73],"highest":[75],"incidence.":[76],"To":[77,136],"mechanisms":[80],"development":[84,107,322],"we":[85,140,163],"recently":[86],"developed":[87],"transgenic":[89],"mouse":[90,153,174],"model":[91],"overexpressing":[92],"CRT":[93],"under":[94,191],"control":[96],"Tie2-promotor.":[98],"The":[99,116,176,198,231,251],"main":[100],"phenotype":[101],"these":[103,254,261,292],"mice":[104],"metastatic":[109,131],"adenocarcinoma":[111,149,296],"similar":[112],"to":[113,123,195,329],"human":[114,155,295],"patients.":[115],"objectives":[117,139],"current":[120],"was":[122,343],"identify":[124],"molecular":[126,332],"pathways":[127,167,217,293],"involved":[128,264,316],"behavior":[132],"adenocarcinoma.":[135],"examine":[137],"our":[138,301],"used":[141],"anchorage":[142],"independent":[143],"adherent":[145,196],"culture":[146],"cells":[150],"isolated":[151],"cell":[156,243,297],"lines.":[157],"Using":[158],"microarray":[159,177],"bioinformatic":[161,199,232],"analysis":[162,178,252],"have":[164],"identified":[165],"several":[166],"genes":[169,182,187,205,239,255,262],"altered":[172],"cells.":[175],"demonstrates":[179],"90":[181],"up-regulated":[184,204],"66":[186],"down":[189],"regulated":[190],"anchorage-independent":[192],"condition":[193],"compared":[194],"conditions.":[197],"analyses":[200,233],"demonstrate":[201,235,259],"implicated":[207,241,272],"cellular":[209,211],"development,":[210],"growth":[212],"proliferation":[214],"pathways.":[215],"These":[216],"include:":[218],"VEGF":[219,224],"signaling,":[220,223],"bladder":[221],"family":[225],"ligand-receptor":[226],"interaction":[227],"Ephrin-receptor":[229],"signaling.":[230,287],"also":[234],"downregulated":[238],"were":[240],"cycle":[244],"regulation":[245,267],"cell-to-cell":[247],"signaling":[248,283],"interaction.":[250],"by":[256,345],"canonical":[257],"pathawy":[258],"very":[269],"relevant":[270],"pathaway":[271],"essentially":[275],":":[276],"Hematopoeisis":[277],"multipotent":[279],"stem":[280],"cells,":[281],"TGF-\u03b2":[282],"tight":[285],"junction":[286],"We":[288],"currently":[290],"examining":[291],"line.":[298],"conclusion,":[300],"data":[302],"illustrate":[303],"although":[305],"calreticulin":[306,337],"an":[308],"endoplasmic":[309],"reticulum":[310],"calcium":[311],"binding":[312],"chaperone,":[313],"it":[314],"process":[319],"tumor":[321,339],"metastasis.":[324],"Further":[325],"work":[326],"needed":[328],"decipher":[330],"mechanism":[333],"involvement":[335],"development.":[340],"This":[341],"research":[342],"funded":[344],"QNRF":[346],"grants":[347],"UREP09-084-3-016":[348],"NPRP4-043-3-016.":[350]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
