{"id":"https://openalex.org/W2005487115","doi":"https://doi.org/10.1111/j.1399-3046.2008.00957.x","title":"Hematopoietic stem cell transplantation in a CD3\u03b3\u2010deficient infant with inflammatory bowel disease","display_name":"Hematopoietic stem cell transplantation in a CD3\u03b3\u2010deficient infant with inflammatory bowel disease","publication_year":2008,"publication_date":"2008-05-11","ids":{"openalex":"https://openalex.org/W2005487115","doi":"https://doi.org/10.1111/j.1399-3046.2008.00957.x","mag":"2005487115","pmid":"https://pubmed.ncbi.nlm.nih.gov/18482219"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-3046.2008.00957.x","doi":"https://doi.org/10.1111/j.1399-3046.2008.00957.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3046.2008.00957.x","pdf_url":null,"source":{"id":"https://openalex.org/S27713550","display_name":"Pediatric Transplantation","issn_l":"1397-3142","issn":["1397-3142","1399-3046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060398629","display_name":"Tuba Turul \u00d6zg\u00fcr","orcid":"https://orcid.org/0000-0003-4545-6151","observed_orcids":["https://orcid.org/0000-0003-4545-6151"]},"institutions":[{"id":"https://openalex.org/I4210115551","display_name":"Hacettepe University Hospital","ror":"https://ror.org/024q5j973","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210115551"]},{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tuba Turul \u00d6zg\u00fcr","raw_affiliation_strings":["Division of Immunology, Hacettepe University Children's Hospital, Ankara, Turkey","Divisions of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Hacettepe University Children's Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210115551","https://openalex.org/I66514158"]},{"raw_affiliation_string":"Divisions of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065910284","display_name":"G\u00fclten T\u00fcrkkan\u0131 Asal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00fclten T\u00fcrkkan\u0131 Asal","raw_affiliation_strings":["Divisions of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036796549","display_name":"D Uckun \u00c7etinkaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. \u00c7etinkaya","raw_affiliation_strings":["Hematology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043498418","display_name":"D\u0131clehan Orhan","orcid":"https://orcid.org/0000-0003-3637-5392","observed_orcids":["https://orcid.org/0000-0003-3637-5392","https://orcid.org/0000-0003-1791-8443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Orhan","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069893143","display_name":"Sara \u015eebnem K\u0131l\u0131\u00e7","orcid":"https://orcid.org/0000-0001-8571-2581","observed_orcids":["https://orcid.org/0000-0001-8571-2581"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S. \u015e. K\u0131l\u0131\u00e7","raw_affiliation_strings":["Division of Immunology, Uludag\u0306 University Children\u2019s Hospital, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Uludag\u0306 University Children\u2019s Hospital, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101710856","display_name":"Yusuf Usta","orcid":"https://orcid.org/0000-0002-0101-6501","observed_orcids":["https://orcid.org/0000-0002-0101-6501"]},"institutions":[{"id":"https://openalex.org/I4210115551","display_name":"Hacettepe University Hospital","ror":"https://ror.org/024q5j973","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210115551"]},{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Y. Usta","raw_affiliation_strings":["Pediatric Gastroenterology, Hacettepe University Children\u2019s Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Gastroenterology, Hacettepe University Children\u2019s Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210115551","https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043531318","display_name":"Hasan \u00d6zen","orcid":"https://orcid.org/0000-0002-9063-3893","observed_orcids":["https://orcid.org/0000-0002-9063-3893","https://orcid.org/0000-0002-6820-2536"]},"institutions":[{"id":"https://openalex.org/I4210115551","display_name":"Hacettepe University Hospital","ror":"https://ror.org/024q5j973","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210115551"]},{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H. \u00d6zen","raw_affiliation_strings":["Pediatric Gastroenterology, Hacettepe University Children\u2019s Hospital, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Gastroenterology, Hacettepe University Children\u2019s Hospital, Ankara, Turkey","institution_ids":["https://openalex.org/I4210115551","https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046604520","display_name":"\u0130lhan Tezcan","orcid":"https://orcid.org/0000-0001-7257-4554","observed_orcids":["https://orcid.org/0000-0001-7257-4554"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u0130lhan Tezcan","raw_affiliation_strings":["Divisions of Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046604520"],"corresponding_institution_ids":[],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.398,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.60254494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"12","issue":"8","first_page":"910","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-combined-immunodeficiency","display_name":"severe combined immunodeficiency","score":0.8840000033378601},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/donor-chimerism","display_name":"donor chimerism","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intractable-diarrhea","display_name":"intractable diarrhea","score":0.7760000228881836},{"id":"https://openalex.org/keywords/rectal-fistula","display_name":"rectal fistula","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pediatric-immunodeficiency","display_name":"pediatric immunodeficiency","score":0.625},{"id":"https://openalex.org/keywords/reduced-intensity-conditioning","display_name":"reduced-intensity conditioning","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9021469950675964},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.6728010773658752},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.5563021302223206},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5562587976455688},{"id":"https://openalex.org/C2776917539","wikidata":"https://www.wikidata.org/wiki/Q1497481","display_name":"Failure to thrive","level":2,"score":0.5065346956253052},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4987475872039795},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39935198426246643},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3661748468875885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35620608925819397},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29606103897094727}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016511","descriptor_name":"Severe Combined Immunodeficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016511","descriptor_name":"Severe Combined Immunodeficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1399-3046.2008.00957.x","doi":"https://doi.org/10.1111/j.1399-3046.2008.00957.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3046.2008.00957.x","pdf_url":null,"source":{"id":"https://openalex.org/S27713550","display_name":"Pediatric Transplantation","issn_l":"1397-3142","issn":["1397-3142","1399-3046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Transplantation","raw_type":"journal-article"},{"id":"pmid:18482219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18482219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric transplantation","raw_type":"Case Reports"},{"id":"pmh:42447bbb-7939-4299-80d0-ff7e34c90f09","doi":null,"is_oa":false,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/42447bbb-7939-4299-80d0-ff7e34c90f09/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324500","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W232318452","https://openalex.org/W1603398928","https://openalex.org/W1693914895","https://openalex.org/W1978972720","https://openalex.org/W1983117044","https://openalex.org/W2008652841","https://openalex.org/W2034437480","https://openalex.org/W2044197209","https://openalex.org/W2052435488","https://openalex.org/W2075570647","https://openalex.org/W2077638616","https://openalex.org/W2108676766","https://openalex.org/W2127315968","https://openalex.org/W2282103947","https://openalex.org/W2340157552","https://openalex.org/W2979846988"],"related_works":["https://openalex.org/W2587650679","https://openalex.org/W7166878575","https://openalex.org/W4304015026","https://openalex.org/W4240560190","https://openalex.org/W2151420807","https://openalex.org/W2948553686","https://openalex.org/W3111499698","https://openalex.org/W1968805507","https://openalex.org/W2385183230","https://openalex.org/W2074128805"],"abstract_inverted_index":{"Partial":[0],"or":[1],"total":[2],"CD3":[3,8,37,45,99],"chain":[4,14,102],"expression":[5,103],"defects":[6],"including":[7],"gamma,":[9],"epsilon,":[10],"delta,":[11],"and":[12,61,121,162,183],"zeta":[13],"are":[15,30],"among":[16],"the":[17,70,98,156],"autosomally":[18],"inherited":[19],"SCID":[20,161],"presenting":[21],"with":[22,25,49,107,141,160],"T-B+NK+":[23],"phenotype":[24],"lymphopenia.":[26],"The":[27,51,133,151],"clinical":[28],"findings":[29],"generally":[31],"severe":[32],"in":[33,117,129],"all":[34],"except":[35],"for":[36],"gamma":[38,46],"deficiency.":[39],"Here":[40],"we":[41],"present":[42],"a":[43,80,84,142],"10-month-old":[44],"deficient":[47],"boy":[48],"IBD.":[50],"patient":[52,134],"had":[53],"suffered":[54],"from":[55,74],"intractable":[56,176],"diarrhea,":[57,118,177],"recurrent":[58],"pulmonary":[59],"infections":[60],"oral":[62],"moniliasis":[63],"since":[64],"two":[65],"months":[66,90],"of":[67,109,175,185],"age.":[68],"Following":[69],"first":[71,157],"allogeneic":[72],"HSCT":[73,171],"his":[75],"HLA-identical":[76],"(6/6)":[77],"sister":[78],"after":[79,95],"reduced":[81],"intensity":[82],"regimen,":[83],"second":[85,96],"transplantation":[86],"was":[87,124,153],"performed":[88],"five":[89],"later.":[91],"On":[92],"day":[93,139],"+19":[94],"transplantation,":[97],"TCR":[100],"alpha/beta":[101],"increased":[104],"to":[105,147,170,179],"66%":[106],"development":[108],"full":[110,173],"donor":[111],"chimerism":[112],"(98.6%).":[113],"A":[114],"significant":[115],"improvement":[116,128,184],"perianal":[119],"lesions,":[120],"rectal":[122],"fistula":[123,186],"observed":[125],"suggesting":[126],"an":[127,148],"inflammatory":[130,163],"bowel":[131,164],"disease.":[132],"died":[135],"at":[136],"home":[137],"on":[138],"+50":[140],"sudden":[143],"respiratory":[144],"failure":[145,178],"secondary":[146],"undetermined":[149],"infection.":[150],"case":[152,159],"interesting":[154],"being":[155],"reported":[158],"disease":[165],"who":[166],"responded":[167],"very":[168],"well":[169],"by":[172],"recovery":[174],"thrive,":[180],"laboratory":[181],"findings,":[182],"formation.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
