{"id":"https://openalex.org/W2005486200","doi":"https://doi.org/10.1371/journal.pone.0102309","title":"Efficacy of Anti-VEGF and Laser Photocoagulation in the Treatment of Visual Impairment due to Diabetic Macular Edema: A Systematic Review and Network Meta-Analysis","display_name":"Efficacy of Anti-VEGF and Laser Photocoagulation in the Treatment of Visual Impairment due to Diabetic Macular Edema: A Systematic Review and Network Meta-Analysis","publication_year":2014,"publication_date":"2014-07-16","ids":{"openalex":"https://openalex.org/W2005486200","doi":"https://doi.org/10.1371/journal.pone.0102309","mag":"2005486200","pmid":"https://pubmed.ncbi.nlm.nih.gov/25029255","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4100770"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0102309","doi":"https://doi.org/10.1371/journal.pone.0102309","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0102309","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102309&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102309&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088567770","display_name":"St\u00e9phane A. R\u00e9gnier","orcid":"https://orcid.org/0000-0002-1994-4648","observed_orcids":["https://orcid.org/0000-0002-1994-4648"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Stephane R\u00e9gnier","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110003511","display_name":"William Malcolm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129647","display_name":"Novartis (United Kingdom)","ror":"https://ror.org/039s6n838","country_code":"GB","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210129647"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Malcolm","raw_affiliation_strings":["Novartis Pharmaceuticals UK Ltd, Frimley Business Park, Frimley, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals UK Ltd, Frimley Business Park, Frimley, Surrey, United Kingdom","institution_ids":["https://openalex.org/I4210129647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036921898","display_name":"Felicity Allen","orcid":"https://orcid.org/0009-0007-8265-5535","observed_orcids":["https://orcid.org/0009-0007-8265-5535"]},"institutions":[{"id":"https://openalex.org/I4210129647","display_name":"Novartis (United Kingdom)","ror":"https://ror.org/039s6n838","country_code":"GB","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210129647"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felicity Allen","raw_affiliation_strings":["Novartis Pharmaceuticals UK Ltd, Frimley Business Park, Frimley, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals UK Ltd, Frimley Business Park, Frimley, Surrey, United Kingdom","institution_ids":["https://openalex.org/I4210129647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103379830","display_name":"Jonathan Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Wright","raw_affiliation_strings":["Numerus Ltd, Wokingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Numerus Ltd, Wokingham, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076066032","display_name":"Vladimir Bezlyak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vladimir Bezlyak","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088567770"],"corresponding_institution_ids":["https://openalex.org/I1283582996"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6782,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.86136595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"e102309","last_page":"e102309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":1.0},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/laser-photocoagulation","display_name":"laser photocoagulation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/best-corrected-visual-acuity","display_name":"best-corrected visual acuity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/visual-impairment","display_name":"visual impairment","score":0.7260000109672546},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.7239999771118164},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5609999895095825},{"id":"https://openalex.org/keywords/central-retinal-thickness","display_name":"central retinal thickness","score":0.7250000238418579},{"id":"https://openalex.org/keywords/retinal-detachment-prevention","display_name":"retinal detachment prevention","score":0.32100000977516174},{"id":"https://openalex.org/keywords/retinal-neovascularization","display_name":"retinal neovascularization","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7072175145149231},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7039582133293152},{"id":"https://openalex.org/C2985127711","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic macular edema","level":4,"score":0.6522866487503052},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6030368208885193},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.500478982925415},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.48479193449020386},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.44749048352241516},{"id":"https://openalex.org/C2781372952","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Visual impairment","level":2,"score":0.44321489334106445},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.4051991105079651},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3226093649864197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28606563806533813},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.22938448190689087},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15957379341125488},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014786","descriptor_name":"Vision Disorders","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017075","descriptor_name":"Laser Coagulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0102309","doi":"https://doi.org/10.1371/journal.pone.0102309","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0102309","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102309&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3071925","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4100770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25029255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25029255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4100770","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4100770/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.769.9132","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.769.9132","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4e/66/pone.0102309.PMC4100770.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pone00:0102309","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102309","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0450ac346e424422b3bf910176680e68","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0450ac346e424422b3bf910176680e68","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 7, p e102309 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1107030","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Efficacy_of_Anti_VEGF_and_Laser_Photocoagulation_in_the_Treatment_of_Visual_Impairment_due_to_Diabetic_Macular_Edema_A_Systematic_Review_and_Network_Meta_Analysis_/1107030","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0102309","doi":"https://doi.org/10.1371/journal.pone.0102309","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0102309","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102309&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005486200.pdf","grobid_xml":"https://content.openalex.org/works/W2005486200.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W580477814","https://openalex.org/W861481711","https://openalex.org/W995558454","https://openalex.org/W1499617936","https://openalex.org/W1526282761","https://openalex.org/W1547832571","https://openalex.org/W1782108791","https://openalex.org/W1872281589","https://openalex.org/W1967385770","https://openalex.org/W1977644809","https://openalex.org/W1980342089","https://openalex.org/W1983275470","https://openalex.org/W1987243228","https://openalex.org/W1996389191","https://openalex.org/W1997000986","https://openalex.org/W1999957425","https://openalex.org/W2000333599","https://openalex.org/W2004474087","https://openalex.org/W2009034333","https://openalex.org/W2016795705","https://openalex.org/W2022886290","https://openalex.org/W2030360754","https://openalex.org/W2037848393","https://openalex.org/W2041509891","https://openalex.org/W2041706806","https://openalex.org/W2047554088","https://openalex.org/W2050122756","https://openalex.org/W2057983131","https://openalex.org/W2059199034","https://openalex.org/W2078355929","https://openalex.org/W2091521408","https://openalex.org/W2093223772","https://openalex.org/W2096060458","https://openalex.org/W2101508556","https://openalex.org/W2102425396","https://openalex.org/W2104740524","https://openalex.org/W2106393433","https://openalex.org/W2109539100","https://openalex.org/W2115756084","https://openalex.org/W2120364631","https://openalex.org/W2123698501","https://openalex.org/W2124348055","https://openalex.org/W2137076161","https://openalex.org/W2148534890","https://openalex.org/W2150529573","https://openalex.org/W2156799887","https://openalex.org/W2161279821","https://openalex.org/W2161588304","https://openalex.org/W2164855431","https://openalex.org/W2406931263","https://openalex.org/W2478829584","https://openalex.org/W2789226077","https://openalex.org/W3184835317","https://openalex.org/W4211205882","https://openalex.org/W4240304626","https://openalex.org/W4243696169","https://openalex.org/W4256306353","https://openalex.org/W4285719527","https://openalex.org/W4300511274","https://openalex.org/W4317927773"],"related_works":["https://openalex.org/W2409308200","https://openalex.org/W2905756099","https://openalex.org/W4411880580","https://openalex.org/W4376958928","https://openalex.org/W2189032197","https://openalex.org/W2493705447","https://openalex.org/W1982068990","https://openalex.org/W7213335261","https://openalex.org/W2981977889","https://openalex.org/W1851059930"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Compare":[1],"the":[2,11,28,110,118,142,185,236,259],"efficacy":[3,193,291],"of":[4,14,61,70,92,112,133,144,194,224,258],"ranibizumab,":[5],"aflibercept,":[6,246],"laser,":[7,251],"and":[8,34,48,98,154,214,227,252,284],"sham":[9],"in":[10,94,103,141,160],"first-line":[12],"treatment":[13,239],"diabetic":[15],"macular":[16],"edema":[17],"(DME)":[18],"to":[19,202,219,282,292],"inform":[20],"technology":[21],"assessments":[22],"such":[23],"as":[24,109],"those":[25],"conducted":[26],"by":[27,131],"UK":[29],"National":[30],"Institute":[31],"for":[32,146,158,181,245,248,254,272],"Health":[33],"Care":[35],"Excellence":[36],"(NICE).":[37],"DATA":[38],"SOURCES:":[39],"MEDLINE,":[40],"Embase,":[41],"Cochrane":[42],"Library,":[43],"congress":[44],"abstracts,":[45],"ClinicalTrials.gov":[46],"registry":[47],"Novartis":[49],"data":[50],"on":[51,90,117,189],"file.":[52],"INCLUSION":[53],"CRITERIA:":[54],"Studies":[55],"reporting":[56],"6-":[57],"or":[58,83,163],"12-month":[59],"results":[60],"randomized":[62],"controlled":[63],"trials":[64],"(RCTs)":[65],"evaluating":[66],"at":[67],"least":[68],"two":[69],"ranibizumab":[71,145,195,234,249],"0.5":[72],"mg":[73,79],"pro":[74],"re":[75],"nata,":[76],"aflibercept":[77,203,215,283],"2.0":[78],"bi-monthly,":[80],"laser":[81,220],"photocoagulation":[82],"sham.":[84],"Study":[85,123],"quality":[86],"was":[87,127,184,196,240,279],"assessed":[88],"based":[89,188],"likelihood":[91],"bias":[93],"selection,":[95],"attrition,":[96],"detection":[97],"performance.":[99],"OUTCOME":[100],"MEASURE:":[101],"Improvement":[102],"best-corrected":[104],"visual":[105],"acuity":[106],"(BCVA)":[107],"measured":[108],"proportion":[111],"patients":[113,172],"gaining":[114],"\u226510":[115],"letters":[116],"Early":[119],"Treatment":[120],"Diabetic":[121],"Retinopathy":[122],"scale.":[124],"The":[125,168,176,192,231,267],"outcome":[126],"chosen":[128],"following":[129],"acceptance":[130],"NICE":[132],"a":[134],"Markov":[135],"model":[136,179,187],"with":[137,152,222,243],"10-letter":[138],"health":[139],"states":[140],"assessment":[143],"DME.":[147],"META-ANALYSIS:":[148],"Bayesian":[149],"network":[150],"meta-analyses":[151],"fixed":[153],"random":[155,177],"effects":[156,178],"adjusted":[157],"differences":[159],"baseline":[161,182],"BCVA":[162,183],"central":[164],"retinal":[165],"thickness.":[166],"RESULTS:":[167],"analysis":[169],"included":[170,262],"1,978":[171],"from":[173],"eight":[174,260],"RCTs.":[175],"adjusting":[180],"best":[186],"total":[190],"residual.":[191],"numerically,":[197],"but":[198],"not":[199,264,270],"statistically,":[200],"superior":[201,218,281,290],"(odds":[204],"ratio":[205],"[OR]":[206],"1.59;":[207],"95%":[208],"credible":[209],"interval":[210],"[CrI],":[211],"0.61-5.37).":[212],"Ranibizumab":[213,278],"were":[216],"statistically":[217,289],"monotherapy":[221],"ORs":[223],"5.50":[225],"(2.73-13.16)":[226],"3.45":[228],"(1.62-6.84)":[229],"respectively.":[230],"probability":[232],"that":[233],"is":[235],"most":[237],"efficacious":[238],"73%":[241],"compared":[242],"14%":[244],"12%":[247],"plus":[250],"0%":[253],"laser.":[255,293],"LIMITATIONS:":[256],"Three":[257],"RCTs":[261],"are":[263],"yet":[265],"published.":[266],"models":[268],"did":[269],"adjust":[271],"all":[273],"potential":[274],"effect":[275],"modifiers.":[276],"CONCLUSION:":[277],"non-significantly":[280],"both":[285],"anti-VEGF":[286],"therapies":[287],"had":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
