{"id":"https://openalex.org/W2005481213","doi":"https://doi.org/10.1083/jcb.200204022","title":"Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase","display_name":"Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase","publication_year":2002,"publication_date":"2002-06-24","ids":{"openalex":"https://openalex.org/W2005481213","doi":"https://doi.org/10.1083/jcb.200204022","mag":"2005481213","pmid":"https://pubmed.ncbi.nlm.nih.gov/12082084"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200204022","doi":"https://doi.org/10.1083/jcb.200204022","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200204022","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2173565","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062367097","display_name":"Donna Louise Cioffi","orcid":"https://orcid.org/0000-0002-8833-128X","observed_orcids":["https://orcid.org/0000-0002-8833-128X"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna L. Cioffi","raw_affiliation_strings":["1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103697291","display_name":"Timothy M. Moore","orcid":"https://orcid.org/0009-0004-0464-9285","observed_orcids":["https://orcid.org/0009-0004-0464-9285"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy M. Moore","raw_affiliation_strings":["1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jerry Schaack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Schaack","raw_affiliation_strings":["3Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027226246","display_name":"Judy R. Creighton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy R. Creighton","raw_affiliation_strings":["1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688","institution_ids":["https://openalex.org/I83809506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112055970","display_name":"Dermot M.F. Cooper","orcid":"https://orcid.org/0000-0001-5327-5241","observed_orcids":["https://orcid.org/0000-0001-5327-5241"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dermot M.F. Cooper","raw_affiliation_strings":["2Departments of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Departments of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048696645","display_name":"Troy Stevens","orcid":"https://orcid.org/0000-0001-9689-929X","observed_orcids":["https://orcid.org/0000-0001-9689-929X"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Troy Stevens","raw_affiliation_strings":["1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688","institution_ids":["https://openalex.org/I83809506"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048696645"],"corresponding_institution_ids":["https://openalex.org/I83809506"],"apc_list":null,"apc_paid":null,"fwci":2.9136,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.91335979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"157","issue":"7","first_page":"1267","last_page":"1278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6349999904632568},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.8960000276565552},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.7509999871253967},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.9359999895095825},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.921999990940094},{"id":"https://openalex.org/keywords/pulmonary-artery-endothelial-cells","display_name":"pulmonary artery endothelial cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.791556715965271},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7647697925567627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6388962268829346},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6113561391830444},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5895806550979614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5318823456764221},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49283480644226074},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4477420747280121},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4377979338169098},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4179856777191162},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.4176226258277893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3834483027458191},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32775551080703735},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1921415627002716},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17662039399147034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07100385427474976}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.200204022","doi":"https://doi.org/10.1083/jcb.200204022","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200204022","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmid:12082084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12082084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2173565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2173565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2173565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2173565","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1077203728","display_name":null,"funder_award_id":"R01 GM32483","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1775865","display_name":"Lung endothelial cell phenotypes","funder_award_id":"P01HL066299","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3108534368","display_name":null,"funder_award_id":"R01 HL060024","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5391559428","display_name":null,"funder_award_id":"R01 GM032483","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G63984100","display_name":null,"funder_award_id":"P01 HL66299","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8181674998","display_name":null,"funder_award_id":"R01 HL60024","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W29546805","https://openalex.org/W1589738157","https://openalex.org/W1802363831","https://openalex.org/W1902718532","https://openalex.org/W1953757484","https://openalex.org/W1962749263","https://openalex.org/W1968210983","https://openalex.org/W1972988807","https://openalex.org/W1977109399","https://openalex.org/W1977766283","https://openalex.org/W1984131924","https://openalex.org/W1987971000","https://openalex.org/W1992879522","https://openalex.org/W1995536774","https://openalex.org/W2000121694","https://openalex.org/W2014866096","https://openalex.org/W2033065775","https://openalex.org/W2039923059","https://openalex.org/W2044296969","https://openalex.org/W2053557358","https://openalex.org/W2055492621","https://openalex.org/W2055618275","https://openalex.org/W2060873952","https://openalex.org/W2063991043","https://openalex.org/W2069280511","https://openalex.org/W2070832223","https://openalex.org/W2076527846","https://openalex.org/W2077206645","https://openalex.org/W2078627324","https://openalex.org/W2078663076","https://openalex.org/W2079499409","https://openalex.org/W2081176170","https://openalex.org/W2084618229","https://openalex.org/W2085275630","https://openalex.org/W2087779473","https://openalex.org/W2090092318","https://openalex.org/W2090363261","https://openalex.org/W2092447733","https://openalex.org/W2097422195","https://openalex.org/W2101449255","https://openalex.org/W2102533478","https://openalex.org/W2106514058","https://openalex.org/W2121672863","https://openalex.org/W2133916339","https://openalex.org/W2135323749","https://openalex.org/W2137434704","https://openalex.org/W2138127317","https://openalex.org/W2138343267","https://openalex.org/W2139041386","https://openalex.org/W2154785597","https://openalex.org/W2155461712","https://openalex.org/W2155657799","https://openalex.org/W2156840546","https://openalex.org/W2158200659","https://openalex.org/W2158713438","https://openalex.org/W2159242529","https://openalex.org/W2163133008","https://openalex.org/W2168380916","https://openalex.org/W2188767162","https://openalex.org/W2200276621","https://openalex.org/W2207249984","https://openalex.org/W2240300013","https://openalex.org/W2256599171","https://openalex.org/W2266658759","https://openalex.org/W2287436660","https://openalex.org/W2331508609","https://openalex.org/W2343740301","https://openalex.org/W2345336816","https://openalex.org/W2399727800","https://openalex.org/W2405661344","https://openalex.org/W2408376652","https://openalex.org/W2418153716","https://openalex.org/W2418638936","https://openalex.org/W2428798956","https://openalex.org/W2433266889","https://openalex.org/W4211094368","https://openalex.org/W4234797349","https://openalex.org/W4253422011","https://openalex.org/W4321429344"],"related_works":["https://openalex.org/W1975310662","https://openalex.org/W1980806930","https://openalex.org/W2076482082","https://openalex.org/W4289985960","https://openalex.org/W2423120987","https://openalex.org/W2050781353","https://openalex.org/W2100463887","https://openalex.org/W2055918680","https://openalex.org/W2042351311","https://openalex.org/W2135678517"],"abstract_inverted_index":{"Acute":[0],"transitions":[1],"in":[2,22,28,34,123,138,152,171,184],"cytosolic":[3],"calcium":[4,8,48,52,106,174,193],"([Ca2+]i)":[5],"through":[6,50],"store-operated":[7,51],"entry":[9,49,53],"channels":[10],"catalyze":[11],"interendothelial":[12],"cell":[13,70,140],"gap":[14,71,136,144,154,182,201],"formation":[15,137,145,155,183],"that":[16,37,98,192],"increases":[17],"permeability.":[18],"However,":[19],"the":[20,29,85,100,188],"rise":[21,33,122],"[Ca2+]i":[23,62,73,121],"only":[24,75],"disrupts":[25],"barrier":[26],"function":[27],"absence":[30],"of":[31,88,110,168,176,195],"a":[32,56,119,172],"cAMP.":[35],"Discovery":[36],"type":[38],"6":[39],"adenylyl":[40],"cyclase":[41],"(AC6;":[42],"EC":[43],"4.6.6.1)":[44],"is":[45,90,197],"inhibited":[46],"by":[47],"pathways":[54],"provided":[55],"plausible":[57],"explanation":[58],"for":[59,68,199],"how":[60],"inflammatory":[61],"mediators":[63,74],"may":[64],"decrease":[65,77],"cAMP":[66,79],"necessary":[67],"endothelial":[69,131,200],"formation.":[72,202],"modestly":[76],"global":[78],"concentrations":[80],"and":[81,128,133,161],"thus,":[82],"to":[83,103],"date,":[84],"physiological":[86],"role":[87],"AC6":[89,196],"unresolved.":[91],"Present":[92],"studies":[93],"used":[94],"an":[95],"adenoviral":[96],"construct":[97],"expresses":[99],"calcium-stimulated":[101],"AC8":[102,169],"convert":[104],"normal":[105],"inhibition":[107,194],"into":[108],"stimulation":[109,175],"cAMP,":[111,177],"within":[112,164],"physiologically":[113],"relevant":[114],"concentration":[115],"ranges.":[116],"Thrombin":[117],"stimulated":[118],"dose-dependent":[120],"both":[124,139],"pulmonary":[125],"artery":[126],"(PAECs)":[127],"microvascular":[129],"(PMVEC)":[130],"cells,":[132],"promoted":[134],"intercellular":[135],"types.":[141],"In":[142],"PAECs,":[143],"was":[146,156],"progressive":[147],"over":[148],"2":[149,165],"h,":[150],"whereas":[151],"PMVECs,":[153],"rapid":[157],"(within":[158],"10":[159],"min)":[160],"gaps":[162],"resealed":[163],"h.":[166],"Expression":[167],"resulted":[170],"modest":[173],"which":[178],"virtually":[179],"abolished":[180],"thrombin-induced":[181],"PMVECs.":[185],"Findings":[186],"provide":[187],"first":[189],"direct":[190],"evidence":[191],"essential":[198]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
