{"id":"https://openalex.org/W2005478495","doi":"https://doi.org/10.1155/2015/247426","title":"Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases","display_name":"Effect of TACI Signaling on Humoral Immunity and Autoimmune Diseases","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2005478495","doi":"https://doi.org/10.1155/2015/247426","mag":"2005478495","pmid":"https://pubmed.ncbi.nlm.nih.gov/25866827"},"language":"en","primary_location":{"id":"doi:10.1155/2015/247426","doi":"https://doi.org/10.1155/2015/247426","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/247426","pdf_url":"https://downloads.hindawi.com/journals/jir/2015/247426.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jir/2015/247426.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100388368","display_name":"Yi Zhang","orcid":"https://orcid.org/0009-0007-7340-3619","observed_orcids":["https://orcid.org/0009-0007-7340-3619"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694874","display_name":"Jun Li","orcid":"https://orcid.org/0000-0001-8192-3744","observed_orcids":["https://orcid.org/0000-0001-8192-3744"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100724536","display_name":"Yamin Zhang","orcid":"https://orcid.org/0000-0002-6515-9106","observed_orcids":["https://orcid.org/0000-0002-6515-9106"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Min Zhang","raw_affiliation_strings":["Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao-Ming Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Ming Zhang","raw_affiliation_strings":["Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056631481","display_name":"Juan Tao","orcid":"https://orcid.org/0000-0001-6571-6649","observed_orcids":["https://orcid.org/0000-0001-6571-6649"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Tao","raw_affiliation_strings":["Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056631481"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":{"value":2830,"currency":"USD","value_usd":2830},"apc_paid":{"value":2830,"currency":"USD","value_usd":2830},"fwci":2.887,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.91161053,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"2015","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/april","display_name":"APRIL","score":0.9079999923706055},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7720000147819519},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/common-variable-immunodeficiency","display_name":"common variable immunodeficiency","score":0.9200000166893005},{"id":"https://openalex.org/keywords/plasma-cell-differentiation","display_name":"plasma cell differentiation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/icosl","display_name":"ICOSL","score":0.996999979019165},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C170286685","wikidata":"https://www.wikidata.org/wiki/Q409346","display_name":"B-cell activating factor","level":4,"score":0.9714396595954895},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7415658235549927},{"id":"https://openalex.org/C2776433325","wikidata":"https://www.wikidata.org/wiki/Q1472818","display_name":"Common variable immunodeficiency","level":3,"score":0.6372514963150024},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5714536905288696},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5066931843757629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46943047642707825},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4246237874031067},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3995361626148224},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3299959897994995},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1331031322479248}],"mesh":[{"descriptor_ui":"D000074462","descriptor_name":"Positive Regulatory Domain I-Binding Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074462","descriptor_name":"Positive Regulatory Domain I-Binding Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074462","descriptor_name":"Positive Regulatory Domain I-Binding Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053264","descriptor_name":"B-Cell Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053264","descriptor_name":"B-Cell Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053264","descriptor_name":"B-Cell Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053303","descriptor_name":"Transmembrane Activator and CAML Interactor Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053303","descriptor_name":"Transmembrane Activator and CAML Interactor Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053303","descriptor_name":"Transmembrane Activator and CAML Interactor Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053303","descriptor_name":"Transmembrane Activator and CAML Interactor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053303","descriptor_name":"Transmembrane Activator and CAML Interactor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053303","descriptor_name":"Transmembrane Activator and CAML Interactor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056724","descriptor_name":"Immunity, Humoral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D060945","descriptor_name":"Inducible T-Cell Co-Stimulator Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060945","descriptor_name":"Inducible T-Cell Co-Stimulator Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060945","descriptor_name":"Inducible T-Cell Co-Stimulator Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2015/247426","doi":"https://doi.org/10.1155/2015/247426","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/247426","pdf_url":"https://downloads.hindawi.com/journals/jir/2015/247426.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},{"id":"pmid:25866827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25866827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3358602","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4381970","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4381970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4381970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Immunol Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a6c667cc4b77412aafcf61fdbbac0ba3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a6c667cc4b77412aafcf61fdbbac0ba3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunology Research, Vol 2015 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2015/247426","doi":"https://doi.org/10.1155/2015/247426","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/247426","pdf_url":"https://downloads.hindawi.com/journals/jir/2015/247426.pdf","source":{"id":"https://openalex.org/S4210178340","display_name":"Journal of Immunology Research","issn_l":"2314-7156","issn":["2314-7156","2314-8861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7799999713897705,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5324100222","display_name":null,"funder_award_id":"81271751","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005478495.pdf","grobid_xml":"https://content.openalex.org/works/W2005478495.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1484311423","https://openalex.org/W1488196937","https://openalex.org/W1492447786","https://openalex.org/W1505026047","https://openalex.org/W1507126592","https://openalex.org/W1520625797","https://openalex.org/W1533387869","https://openalex.org/W1576418375","https://openalex.org/W1600749829","https://openalex.org/W1625166229","https://openalex.org/W1651020066","https://openalex.org/W1863374972","https://openalex.org/W1920115643","https://openalex.org/W1964701274","https://openalex.org/W1965094936","https://openalex.org/W1965924845","https://openalex.org/W1967061388","https://openalex.org/W1968960762","https://openalex.org/W1970642695","https://openalex.org/W1973389611","https://openalex.org/W1975085076","https://openalex.org/W1976188142","https://openalex.org/W1978302597","https://openalex.org/W1979128017","https://openalex.org/W1982924102","https://openalex.org/W1983366728","https://openalex.org/W1985047368","https://openalex.org/W1989273660","https://openalex.org/W1989279522","https://openalex.org/W1990070916","https://openalex.org/W1993219448","https://openalex.org/W2000620108","https://openalex.org/W2009122123","https://openalex.org/W2012938206","https://openalex.org/W2014956545","https://openalex.org/W2016304443","https://openalex.org/W2017328208","https://openalex.org/W2017712914","https://openalex.org/W2019990958","https://openalex.org/W2023223254","https://openalex.org/W2026284067","https://openalex.org/W2027616862","https://openalex.org/W2029980677","https://openalex.org/W2031231728","https://openalex.org/W2035237509","https://openalex.org/W2035681212","https://openalex.org/W2037708347","https://openalex.org/W2038264470","https://openalex.org/W2039909221","https://openalex.org/W2046330020","https://openalex.org/W2047865956","https://openalex.org/W2052702521","https://openalex.org/W2055816409","https://openalex.org/W2057800919","https://openalex.org/W2059318379","https://openalex.org/W2059622714","https://openalex.org/W2065152431","https://openalex.org/W2083221597","https://openalex.org/W2090851364","https://openalex.org/W2092035748","https://openalex.org/W2092047962","https://openalex.org/W2092567494","https://openalex.org/W2094139263","https://openalex.org/W2096067806","https://openalex.org/W2102002623","https://openalex.org/W2104691273","https://openalex.org/W2105127129","https://openalex.org/W2105314435","https://openalex.org/W2108072531","https://openalex.org/W2113335928","https://openalex.org/W2116063836","https://openalex.org/W2128500253","https://openalex.org/W2131457901","https://openalex.org/W2132773720","https://openalex.org/W2134125940","https://openalex.org/W2134877002","https://openalex.org/W2136149088","https://openalex.org/W2139624120","https://openalex.org/W2141832908","https://openalex.org/W2141999252","https://openalex.org/W2144430905","https://openalex.org/W2149186863","https://openalex.org/W2149408154","https://openalex.org/W2150721047","https://openalex.org/W2152417566","https://openalex.org/W2154841949","https://openalex.org/W2157981766","https://openalex.org/W2161934458","https://openalex.org/W2162452586","https://openalex.org/W2162614403","https://openalex.org/W2165370936","https://openalex.org/W2167012225","https://openalex.org/W2167914167","https://openalex.org/W2168790805","https://openalex.org/W2616695328"],"related_works":["https://openalex.org/W1963876979","https://openalex.org/W2148749566","https://openalex.org/W4313388268","https://openalex.org/W1974385187","https://openalex.org/W2745071332","https://openalex.org/W2113313059","https://openalex.org/W2016644856","https://openalex.org/W122015468","https://openalex.org/W2079870022","https://openalex.org/W4313388345"],"abstract_inverted_index":{"Transmembrane":[0],"activator":[1],"and":[2,25,43,47,73,114,158,160,191],"calcium-modulating":[3],"cyclophilin":[4],"ligand":[5,28,77],"interactor":[6],"(TACI)":[7],"is":[8,31],"one":[9],"of":[10,13,18,49,61,121,130,142,153,168,182,194,199],"the":[11,19,35,45,140,150,154,162,166,176,180,192,197],"receptors":[12],"B":[14,40,67,80],"cell":[15,41],"activating":[16],"factor":[17,22],"tumor":[20],"necrosis":[21],"family":[23],"(BAFF)":[24],"a":[26,32],"proliferation-inducing":[27],"(APRIL).":[29],"TACI":[30,38,87,104,131,155,169,186,195],"regulator":[33],"in":[34,79,103,170,196],"immune":[36,96,135],"responses.":[37],"inhibits":[39],"expansion":[42],"promotes":[44],"differentiation":[46],"survival":[48],"plasma":[50,83],"cells.":[51,84],"The":[52],"mechanisms":[53,178],"underlying":[54,179],"these":[55],"effects":[56],"probably":[57],"involve":[58],"changed":[59],"expressions":[60],"some":[62],"crucial":[63],"molecules,":[64],"such":[65],"as":[66],"lymphocyte":[68],"induced":[69],"maturation":[70],"protein-1":[71],"(Blimp-1)":[72],"inducible":[74],"T-cell":[75],"costimulator":[76],"(ICOSL)":[78],"cells":[81],"and/or":[82],"However,":[85],"abnormal":[86],"signaling":[88,132],"may":[89,133],"relate":[90],"to":[91,108,188],"autoimmune":[92,109,143,189],"disorders.":[93],"Common":[94],"variable":[95],"deficiency":[97],"(CVID)":[98],"patients":[99,184],"with":[100,185],"heterozygous":[101],"mutations":[102,187],"alleles":[105],"increase":[106],"susceptibility":[107,181],"diseases.":[110,144],"Taci":[111],"(-/-)":[112],"mice":[113,117],"BAFF":[115,157],"transgenic":[116],"both":[118],"develop":[119],"signs":[120],"human":[122],"SLE.":[123,200],"These":[124],"findings":[125,164],"that":[126],"indicate":[127],"inappropriate":[128],"levels":[129],"disrupt":[134],"system":[136],"balance,":[137],"thereby":[138],"promoting":[139],"development":[141],"In":[145],"this":[146],"review,":[147],"we":[148],"summarize":[149],"basic":[151],"characteristics":[152],"ligands":[156],"APRIL,":[159],"detail":[161],"research":[163],"on":[165],"role":[167,193],"humoral":[171],"immunity.":[172],"We":[173],"also":[174],"discuss":[175],"possible":[177],"CVID":[183],"diseases":[190],"pathogenesis":[198]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}