{"id":"https://openalex.org/W2005477803","doi":"https://doi.org/10.1021/np400943b","title":"Identification of Isosilybin A from Milk Thistle Seeds as an Agonist of Peroxisome Proliferator-Activated Receptor Gamma","display_name":"Identification of Isosilybin A from Milk Thistle Seeds as an Agonist of Peroxisome Proliferator-Activated Receptor Gamma","publication_year":2014,"publication_date":"2014-03-05","ids":{"openalex":"https://openalex.org/W2005477803","doi":"https://doi.org/10.1021/np400943b","mag":"2005477803","pmid":"https://pubmed.ncbi.nlm.nih.gov/24597776"},"language":"en","primary_location":{"id":"doi:10.1021/np400943b","doi":"https://doi.org/10.1021/np400943b","is_oa":true,"landing_page_url":"https://doi.org/10.1021/np400943b","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/np400943b?ref=article_openPDF","source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/np400943b?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022218438","display_name":"Eva\u2010Maria Pferschy\u2010Wenzig","orcid":"https://orcid.org/0000-0001-8327-0732","observed_orcids":["https://orcid.org/0000-0001-8327-0732"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Eva-Maria Pferschy-Wenzig","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz, Austria","Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz , Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz, Austria","institution_ids":["https://openalex.org/I15766117"]},{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz , Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061155886","display_name":"Atanas G. Atanasov","orcid":"https://orcid.org/0000-0003-2545-0967","observed_orcids":["https://orcid.org/0000-0003-2545-0967"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Atanas G. Atanasov","raw_affiliation_strings":["Department of Pharmacognosy, University of Vienna, Austria","Department#R#of Pharmacognosy, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department#R#of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110338586","display_name":"Clemens Malainer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Clemens Malainer","raw_affiliation_strings":["Department of Pharmacognosy, University of Vienna, Austria","Department#R#of Pharmacognosy, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department#R#of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046851086","display_name":"Stefan M. Noha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Stefan M. Noha","raw_affiliation_strings":["Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Austria","Institute#R#of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences#R#Innsbruck (CMBI), University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]},{"raw_affiliation_string":"Institute#R#of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences#R#Innsbruck (CMBI), University of Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084574387","display_name":"Olaf Kunert","orcid":"https://orcid.org/0000-0002-7091-5973","observed_orcids":["https://orcid.org/0000-0002-7091-5973"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Olaf Kunert","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University Graz, Austria","Institute#R#of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University Graz, Austria","institution_ids":["https://openalex.org/I15766117"]},{"raw_affiliation_string":"Institute#R#of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005983172","display_name":"Daniela Schuster","orcid":"https://orcid.org/0000-0002-9933-8938","observed_orcids":["https://orcid.org/0000-0002-9933-8938","https://orcid.org/0000-0003-3300-6989"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Daniela Schuster","raw_affiliation_strings":["Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Austria","Institute#R#of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences#R#Innsbruck (CMBI), University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]},{"raw_affiliation_string":"Institute#R#of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences#R#Innsbruck (CMBI), University of Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086995430","display_name":"Elke H. Hei\u00df","orcid":"https://orcid.org/0000-0001-7618-5505","observed_orcids":["https://orcid.org/0000-0001-7618-5505"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Elke H. Heiss","raw_affiliation_strings":["Department of Pharmacognosy, University of Vienna, Austria","Department#R#of Pharmacognosy, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department#R#of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011810695","display_name":"Nicholas H. Oberlies","orcid":"https://orcid.org/0000-0002-0354-8464","observed_orcids":["https://orcid.org/0000-0002-0354-8464"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas H. Oberlies","raw_affiliation_strings":["Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111600308","display_name":"Hildebert Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hildebert Wagner","raw_affiliation_strings":["Department f\u00fcr Pharmazie, Zentrum f\u00fcr Pharmazieforschung, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department f\u00fcr Pharmazie, Zentrum f\u00fcr Pharmazieforschung, Ludwig Maximilians Universit\u00e4t M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027041544","display_name":"Rudolf Bauer","orcid":"https://orcid.org/0000-0002-0057-5547","observed_orcids":["https://orcid.org/0000-0002-0057-5547"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Rudolf Bauer","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz, Austria","Institute#R#of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz, Austria","institution_ids":["https://openalex.org/I15766117"]},{"raw_affiliation_string":"Institute#R#of Pharmaceutical Sciences, Department of Pharmacognosy, University Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016487204","display_name":"Verena Maria Dirsch","orcid":"https://orcid.org/0000-0002-9261-5293","observed_orcids":["https://orcid.org/0000-0002-9261-5293"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Verena M. Dirsch","raw_affiliation_strings":["Department of Pharmacognosy, University of Vienna, Austria","Department#R#of Pharmacognosy, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"Department#R#of Pharmacognosy, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5061155886"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":2179,"currency":"EUR","value_usd":2350},"fwci":5.5733,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.96135177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"77","issue":"4","first_page":"842","last_page":"847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.777999997138977},{"id":"https://openalex.org/keywords/silymarin","display_name":"silymarin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/milk-thistle","display_name":"Silybum marianum","score":0.9520000219345093},{"id":"https://openalex.org/keywords/milk-thistle-seeds","display_name":"milk thistle seeds","score":0.9200000166893005},{"id":"https://openalex.org/keywords/flavonolignans","display_name":"flavonolignans","score":0.984000027179718},{"id":"https://openalex.org/keywords/nuclear-receptor-transactivation","display_name":"nuclear receptor transactivation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.7289999723434448},{"id":"https://openalex.org/keywords/t0070907","display_name":"T0070907","score":0.8349999785423279},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8460000157356262},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2780210117","wikidata":"https://www.wikidata.org/wiki/Q193798","display_name":"Silybum marianum","level":2,"score":0.8711623549461365},{"id":"https://openalex.org/C2909423643","wikidata":"https://www.wikidata.org/wiki/Q193798","display_name":"Milk Thistle","level":2,"score":0.7230874300003052},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.7220419049263},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.6639196276664734},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.636486828327179},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6282917857170105},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.5707271695137024},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5505181550979614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5221638679504395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5078123211860657},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4749990701675415},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.4708116948604584},{"id":"https://openalex.org/C188413054","wikidata":"https://www.wikidata.org/wiki/Q18030677","display_name":"Peroxisome proliferator-activated receptor alpha","level":5,"score":0.4242263436317444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3425719738006592},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1742837131023407},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012838","descriptor_name":"Silymarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020944","descriptor_name":"Silybum marianum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020944","descriptor_name":"Silybum marianum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020944","descriptor_name":"Silybum marianum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020944","descriptor_name":"Silybum marianum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/np400943b","doi":"https://doi.org/10.1021/np400943b","is_oa":true,"landing_page_url":"https://doi.org/10.1021/np400943b","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/np400943b?ref=article_openPDF","source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:24597776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24597776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2979733","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC4003856","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4003856","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4003856","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Nat Prod","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/np400943b","doi":"https://doi.org/10.1021/np400943b","is_oa":true,"landing_page_url":"https://doi.org/10.1021/np400943b","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/np400943b?ref=article_openPDF","source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6800000071525574}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1689950459","display_name":null,"funder_award_id":"R01AT006842","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005477803.pdf","grobid_xml":"https://content.openalex.org/works/W2005477803.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1965372133","https://openalex.org/W1966531138","https://openalex.org/W1968659767","https://openalex.org/W1972123715","https://openalex.org/W1973866760","https://openalex.org/W1977041568","https://openalex.org/W1979761686","https://openalex.org/W1983519362","https://openalex.org/W1984212172","https://openalex.org/W1992716708","https://openalex.org/W1992808568","https://openalex.org/W1995976759","https://openalex.org/W1996637590","https://openalex.org/W1998639145","https://openalex.org/W2002046476","https://openalex.org/W2003808348","https://openalex.org/W2007582789","https://openalex.org/W2007903595","https://openalex.org/W2010446492","https://openalex.org/W2011236197","https://openalex.org/W2030085966","https://openalex.org/W2031874966","https://openalex.org/W2036247576","https://openalex.org/W2045327489","https://openalex.org/W2047591801","https://openalex.org/W2071857075","https://openalex.org/W2073578030","https://openalex.org/W2073915513","https://openalex.org/W2080094617","https://openalex.org/W2083600284","https://openalex.org/W2086890732","https://openalex.org/W2089229769","https://openalex.org/W2099230287","https://openalex.org/W2102210313","https://openalex.org/W2106260565","https://openalex.org/W2109221964","https://openalex.org/W2113474129","https://openalex.org/W2117701880","https://openalex.org/W2124843670","https://openalex.org/W2130479394","https://openalex.org/W2132305924","https://openalex.org/W2134389003","https://openalex.org/W2134489063","https://openalex.org/W2143384643","https://openalex.org/W2147814165","https://openalex.org/W2149697993","https://openalex.org/W2154105843","https://openalex.org/W2157335302","https://openalex.org/W2158325426","https://openalex.org/W2163810943"],"related_works":["https://openalex.org/W4243995007","https://openalex.org/W4254195905","https://openalex.org/W4244370410","https://openalex.org/W4240304786","https://openalex.org/W2181316817","https://openalex.org/W3105123144","https://openalex.org/W4210935136","https://openalex.org/W2892230529","https://openalex.org/W1797200506","https://openalex.org/W2409588963"],"abstract_inverted_index":{"Peroxisome":[0],"proliferator-activated":[1],"receptor":[2,18],"gamma":[3],"(PPAR\u03b3)":[4],"is":[5,56],"a":[6,33,46,60,67,93,98,118,167],"key":[7],"regulator":[8],"of":[9,15,24,36,66,69,79,92,126,142,146,169],"glucose":[10],"and":[11,28,81],"lipid":[12],"metabolism.":[13],"Agonists":[14],"this":[16,73,170],"nuclear":[17,171],"are":[19,29],"used":[20,57],"in":[21,63,97,138],"the":[22,64,75,109,127,139,143,147,157],"treatment":[23,35,65],"type":[25],"2":[26],"diabetes":[27],"also":[30],"studied":[31],"as":[32,59,156,166],"potential":[34,78],"other":[37],"metabolic":[38],"diseases,":[39],"including":[40],"nonalcoholic":[41],"fatty":[42],"liver":[43,70],"disease.":[44],"Silymarin,":[45],"concentrated":[47],"phenolic":[48],"mixture":[49],"from":[50,124],"milk":[51],"thistle":[52],"(Silybum":[53],"marianum)":[54],"seeds,":[55],"widely":[58],"supportive":[61],"agent":[62],"variety":[68],"diseases.":[71],"In":[72,113],"study,":[74],"PPAR\u03b3":[76,110,160],"activation":[77],"silymarin":[80,129],"its":[82,163],"main":[83],"constituents":[84],"was":[85],"investigated.":[86],"Isosilybin":[87],"A":[88,151],"(3)":[89,152],"caused":[90],"transactivation":[91],"PPAR\u03b3-dependent":[94],"luciferase":[95],"reporter":[96],"concentration-dependent":[99],"manner.":[100],"This":[101],"effect":[102],"could":[103],"be":[104],"reversed":[105],"upon":[106],"co-treatment":[107],"with":[108,131],"antagonist":[111],"T0070907.":[112],"silico":[114],"docking":[115],"studies":[116],"suggested":[117],"binding":[119],"mode":[120],"for":[121],"3":[122],"distinct":[123],"that":[125],"inactive":[128],"constituents,":[130],"one":[132],"additional":[133],"hydrogen":[134],"bond":[135],"to":[136],"Ser342":[137],"entrance":[140],"region":[141],"ligand-binding":[144],"domain":[145],"receptor.":[148,172],"Hence,":[149],"isosilybin":[150],"has":[153],"been":[154],"identified":[155],"first":[158],"flavonolignan":[159],"agonist,":[161],"suggesting":[162],"further":[164],"investigation":[165],"modulator":[168]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
