{"id":"https://openalex.org/W2005476349","doi":"https://doi.org/10.1016/0047-6374(85)90050-8","title":"Appearance of extrachromosomal circular DNAs during in vivo and in vitro ageing of mammalian cells","display_name":"Appearance of extrachromosomal circular DNAs during in vivo and in vitro ageing of mammalian cells","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2005476349","doi":"https://doi.org/10.1016/0047-6374(85)90050-8","mag":"2005476349","pmid":"https://pubmed.ncbi.nlm.nih.gov/3982086"},"language":"en","primary_location":{"id":"doi:10.1016/0047-6374(85)90050-8","doi":"https://doi.org/10.1016/0047-6374(85)90050-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0047-6374(85)90050-8","pdf_url":null,"source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003472940","display_name":"Takahiro Kunisada","orcid":"https://orcid.org/0000-0003-1651-2716","observed_orcids":["https://orcid.org/0000-0003-1651-2716"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Kunisada","raw_affiliation_strings":["Department of Biophysics, Faculty of Science, Kyoto University, Sakyo\u2010ku, Kyoto 606, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Science, Kyoto University, Sakyo\u2010ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063582557","display_name":"Hideo Yamagishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideo Yamagishi","raw_affiliation_strings":["Department of Biophysics, Faculty of Science, Kyoto University, Sakyo\u2010ku, Kyoto 606, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Science, Kyoto University, Sakyo\u2010ku, Kyoto 606, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111692583","display_name":"Zen-ichi Ogita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zen-ichi Ogita","raw_affiliation_strings":["Research Institute for Oriental Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-01 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Oriental Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-01 Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086247955","display_name":"Tadashi Kirakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Kirakawa","raw_affiliation_strings":["Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173 Japan","institution_ids":["https://openalex.org/I4210140609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023488159","display_name":"Youji Mitsui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140609","display_name":"Tokyo Metropolitan Institute of Gerontology","ror":"https://ror.org/03rd0p893","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210140609"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Youji Mitsui","raw_affiliation_strings":["Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173 Japan","institution_ids":["https://openalex.org/I4210140609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063582557"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":1.0367,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.72177539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"1","first_page":"89","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.17100000381469727,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extrachromosomal-circular-dna","display_name":"extrachromosomal circular DNA","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.968999981880188},{"id":"https://openalex.org/keywords/werner-syndrome","display_name":"Werner syndrome","score":0.7900000214576721},{"id":"https://openalex.org/keywords/dna-rearrangement","display_name":"DNA rearrangement","score":0.5680000185966492},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.6060000061988831},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-fragment-size-distribution","display_name":"DNA fragment size distribution","score":0.6890000104904175},{"id":"https://openalex.org/keywords/copy-number","display_name":"copy number","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C89684784","wikidata":"https://www.wikidata.org/wiki/Q5422184","display_name":"Extrachromosomal DNA","level":4,"score":0.9858707189559937},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.7481595277786255},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7001297473907471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6815779805183411},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6385592818260193},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6125828623771667},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5765738487243652},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5626459121704102},{"id":"https://openalex.org/C42625924","wikidata":"https://www.wikidata.org/wiki/Q2819111","display_name":"Circular DNA","level":4,"score":0.4804667830467224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3821749985218048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37939050793647766},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3199493885040283},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.1586197018623352},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.14136716723442078}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014898","descriptor_name":"Werner Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0047-6374(85)90050-8","doi":"https://doi.org/10.1016/0047-6374(85)90050-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0047-6374(85)90050-8","pdf_url":null,"source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},{"id":"pmid:3982086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3982086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of ageing and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W159681246","https://openalex.org/W193294183","https://openalex.org/W1718335784","https://openalex.org/W1864473019","https://openalex.org/W1963984598","https://openalex.org/W1964063193","https://openalex.org/W1966221494","https://openalex.org/W1973312829","https://openalex.org/W1992694822","https://openalex.org/W2002180347","https://openalex.org/W2009420343","https://openalex.org/W2026518911","https://openalex.org/W2027112178","https://openalex.org/W2030108584","https://openalex.org/W2033580579","https://openalex.org/W2049934480","https://openalex.org/W2051146905","https://openalex.org/W2054785805","https://openalex.org/W2060578549","https://openalex.org/W2063912566","https://openalex.org/W2069946179","https://openalex.org/W2073567260","https://openalex.org/W2075802915","https://openalex.org/W2080612757","https://openalex.org/W2083847647","https://openalex.org/W2090297735","https://openalex.org/W2092675029","https://openalex.org/W2100459890","https://openalex.org/W2171915810","https://openalex.org/W2324317285","https://openalex.org/W2414858718","https://openalex.org/W4237144225","https://openalex.org/W6685105050","https://openalex.org/W7099801014"],"related_works":["https://openalex.org/W2016612223","https://openalex.org/W178334492","https://openalex.org/W1987312118","https://openalex.org/W1973312829","https://openalex.org/W2905153325","https://openalex.org/W1964355852","https://openalex.org/W3014294158","https://openalex.org/W3040517865","https://openalex.org/W3017249887","https://openalex.org/W1963578989"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
