{"id":"https://openalex.org/W2005475021","doi":"https://doi.org/10.1016/j.fct.2012.02.039","title":"Toxicokinetics and lack of uterotropic effect of orally administered S-equol","display_name":"Toxicokinetics and lack of uterotropic effect of orally administered S-equol","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2005475021","doi":"https://doi.org/10.1016/j.fct.2012.02.039","mag":"2005475021","pmid":"https://pubmed.ncbi.nlm.nih.gov/22406328"},"language":"en","primary_location":{"id":"doi:10.1016/j.fct.2012.02.039","doi":"https://doi.org/10.1016/j.fct.2012.02.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fct.2012.02.039","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076233115","display_name":"Richard J. Schwen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Richard J. Schwen","raw_affiliation_strings":["Ausio Pharmaceuticals, LLC, Cincinnati, Ohio 45212, USA. rick@ausiopharma.com","Ausio Pharmaceuticals, LLC, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ausio Pharmaceuticals, LLC, Cincinnati, Ohio 45212, USA. rick@ausiopharma.com","institution_ids":[]},{"raw_affiliation_string":"Ausio Pharmaceuticals, LLC, Cincinnati, Ohio, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Linh Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287661","display_name":"Charles River Laboratories (Canada)","ror":"https://ror.org/05t7q1f51","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210126295","https://openalex.org/I4405287661"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Linh Nguyen","raw_affiliation_strings":["Charles River Laboratories, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles River Laboratories, Montreal, Canada","institution_ids":["https://openalex.org/I4405287661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080653240","display_name":"Jeffrey B. Plomley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287661","display_name":"Charles River Laboratories (Canada)","ror":"https://ror.org/05t7q1f51","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210126295","https://openalex.org/I4405287661"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey B. Plomley","raw_affiliation_strings":["Charles River Laboratories, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles River Laboratories, Montreal, Canada","institution_ids":["https://openalex.org/I4405287661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081851324","display_name":"Richard L. Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard L. Jackson","raw_affiliation_strings":["Ausio Pharmaceuticals, LLC, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ausio Pharmaceuticals, LLC, Cincinnati, Ohio, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076233115"],"corresponding_institution_ids":[],"apc_list":{"value":4670,"currency":"USD","value_usd":4670},"apc_paid":null,"fwci":2.7843,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88676401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"50","issue":"5","first_page":"1741","last_page":"1748"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-equol","display_name":"S-equol","score":1.0},{"id":"https://openalex.org/keywords/toxicokinetics","display_name":"toxicokinetics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/daidzein","display_name":"daidzein","score":0.7379999756813049},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.8960000276565552},{"id":"https://openalex.org/keywords/soybean","display_name":"soybean","score":0.8389999866485596},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.9589999914169312},{"id":"https://openalex.org/keywords/oral-absorption","display_name":"oral absorption","score":0.4869999885559082},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.5519999861717224},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2781262405","wikidata":"https://www.wikidata.org/wiki/Q5384747","display_name":"Equol","level":4,"score":0.9936054348945618},{"id":"https://openalex.org/C2780955279","wikidata":"https://www.wikidata.org/wiki/Q408732","display_name":"Daidzein","level":3,"score":0.8265641927719116},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5561806559562683},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5376985669136047},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.5369690656661987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5343709588050842},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5174732804298401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48818832635879517},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45910903811454773},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4511987566947937},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.4431937336921692},{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.4015081524848938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29155948758125305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25285059213638306},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060754","descriptor_name":"Equol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D060754","descriptor_name":"Equol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D060754","descriptor_name":"Equol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.fct.2012.02.039","doi":"https://doi.org/10.1016/j.fct.2012.02.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fct.2012.02.039","pdf_url":null,"source":{"id":"https://openalex.org/S84231135","display_name":"Food and Chemical Toxicology","issn_l":"0278-6915","issn":["0278-6915","1873-6351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and Chemical Toxicology","raw_type":"journal-article"},{"id":"pmid:22406328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22406328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W154734720","https://openalex.org/W1593442063","https://openalex.org/W1951469402","https://openalex.org/W1967815458","https://openalex.org/W1978012579","https://openalex.org/W1983715590","https://openalex.org/W1988468201","https://openalex.org/W2002095099","https://openalex.org/W2004413644","https://openalex.org/W2021589042","https://openalex.org/W2030722861","https://openalex.org/W2043397773","https://openalex.org/W2049415617","https://openalex.org/W2072680986","https://openalex.org/W2084456197","https://openalex.org/W2089693058","https://openalex.org/W2096809508","https://openalex.org/W2106381327","https://openalex.org/W2107093217","https://openalex.org/W2110115324","https://openalex.org/W2112857734","https://openalex.org/W2114333459","https://openalex.org/W2114878762","https://openalex.org/W2118089000","https://openalex.org/W2125689691","https://openalex.org/W2152964734","https://openalex.org/W2321445417"],"related_works":["https://openalex.org/W2072680986","https://openalex.org/W2096809508","https://openalex.org/W2004413644","https://openalex.org/W2144046237","https://openalex.org/W1997017782","https://openalex.org/W2287290621","https://openalex.org/W2003852109","https://openalex.org/W1846867852","https://openalex.org/W2043397773","https://openalex.org/W4311201381"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}