{"id":"https://openalex.org/W2005474338","doi":"https://doi.org/10.1186/2051-1426-1-s1-p265","title":"Neutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors","display_name":"Neutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2005474338","doi":"https://doi.org/10.1186/2051-1426-1-s1-p265","mag":"2005474338"},"language":"en","primary_location":{"id":"doi:10.1186/2051-1426-1-s1-p265","doi":"https://doi.org/10.1186/2051-1426-1-s1-p265","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2051-1426-1-s1-p265","pdf_url":"https://jitc.bmj.com/content/jitc/1/Suppl_1/P265.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/1/Suppl_1/P265.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005504613","display_name":"Steven Lorenz Highfill","orcid":"https://orcid.org/0000-0003-0135-0961","observed_orcids":["https://orcid.org/0000-0003-0135-0961"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven L Highfill","raw_affiliation_strings":["grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","Pediatric Oncology Branch, NCI, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053421752","display_name":"Adrienne H. Long","orcid":"https://orcid.org/0000-0002-1523-9095","observed_orcids":["https://orcid.org/0000-0002-1523-9095"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne H Long","raw_affiliation_strings":["grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","Pediatric Oncology Branch, NCI, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017546318","display_name":"Rimas J. Orentas","orcid":"https://orcid.org/0000-0002-6310-3467","observed_orcids":["https://orcid.org/0000-0002-6310-3467"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rimas J Orentas","raw_affiliation_strings":["grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","Pediatric Oncology Branch, NCI, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087779758","display_name":"Crystal Lee Mackall","orcid":"https://orcid.org/0000-0003-0359-9023","observed_orcids":["https://orcid.org/0000-0003-0359-9023","https://orcid.org/0000-0001-6323-4304"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal L Mackall","raw_affiliation_strings":["grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","Pediatric Oncology Branch, NCI, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.48336.3a0000000419368075Pediatric Oncology BranchNCI\nBethesda\nMD\nUSA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Oncology Branch, NCI, Bethesda, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.3558,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6494403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"1","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neutralization","display_name":"neutralization","score":0.6710000038146973},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/pediatric-solid-tumors","display_name":"pediatric solid tumors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8659108877182007},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6028004884719849},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5709776282310486},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5182254314422607},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4829515814781189},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45529013872146606},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.42228686809539795},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3928508162498474},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3440122604370117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3254627585411072},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2902200222015381},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1573786437511444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14026504755020142}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2051-1426-1-s1-p265","doi":"https://doi.org/10.1186/2051-1426-1-s1-p265","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2051-1426-1-s1-p265","pdf_url":"https://jitc.bmj.com/content/jitc/1/Suppl_1/P265.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2985815","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3990346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3990346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3990346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Immunother Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2051-1426-1-s1-p265","doi":"https://doi.org/10.1186/2051-1426-1-s1-p265","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2051-1426-1-s1-p265","pdf_url":"https://jitc.bmj.com/content/jitc/1/Suppl_1/P265.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal for ImmunoTherapy of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005474338.pdf","grobid_xml":"https://content.openalex.org/works/W2005474338.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3011268210","https://openalex.org/W3024178724","https://openalex.org/W4311588896","https://openalex.org/W2238242969","https://openalex.org/W4381594543","https://openalex.org/W4387955394","https://openalex.org/W3194509958","https://openalex.org/W3032483461","https://openalex.org/W3029001555","https://openalex.org/W4292999382"],"abstract_inverted_index":{"Meeting":[0],"abstracts":[1],"Genetically":[2],"engineered":[3],"T-cells":[4],"that":[5,37],"express":[6],"chimeric":[7],"antigen":[8],"receptors":[9],"(CARs)":[10],"to":[11],"directly":[12],"target":[13],"tumor-expressed":[14],"antigens":[15],"have":[16],"shown":[17],"remarkable":[18],"activity":[19],"in":[20,38],"clinical":[21],"trials":[22],"for":[23,29],"hematologic":[24],"malignancies,":[25],"but":[26],"remain":[27],"unproven":[28],"the":[30],"treatment":[31],"of":[32],"solid":[33],"tumors.":[34],"We":[35],"find":[36],"addition":[39]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
