{"id":"https://openalex.org/W2005472350","doi":"https://doi.org/10.1097/maj.0b013e31822a6c47","title":"Is Informed Consent Broken?","display_name":"Is Informed Consent Broken?","publication_year":2011,"publication_date":"2011-08-04","ids":{"openalex":"https://openalex.org/W2005472350","doi":"https://doi.org/10.1097/maj.0b013e31822a6c47","mag":"2005472350","pmid":"https://pubmed.ncbi.nlm.nih.gov/21817873"},"language":"en","primary_location":{"id":"doi:10.1097/maj.0b013e31822a6c47","doi":"https://doi.org/10.1097/maj.0b013e31822a6c47","is_oa":false,"landing_page_url":"https://doi.org/10.1097/maj.0b013e31822a6c47","pdf_url":null,"source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068853592","display_name":"Gail E. Henderson","orcid":"https://orcid.org/0000-0002-4968-7064","observed_orcids":["https://orcid.org/0000-0002-4968-7064"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gail E. Henderson","raw_affiliation_strings":["Department of Social Medicine, School of Medicine, University of North Carolina at Chapel Hill, 333 South Columbia Street, Rm 347 MacNider, Chapel Hill, NC 2799-7240, USA. ghenders@med.unc.edu","Department of Social Medicine, UNC School of Medicine and Clinical Research Ethics Core, NC TraCS, and the Center for Genomics and Society, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Social Medicine, School of Medicine, University of North Carolina at Chapel Hill, 333 South Columbia Street, Rm 347 MacNider, Chapel Hill, NC 2799-7240, USA. ghenders@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Social Medicine, UNC School of Medicine and Clinical Research Ethics Core, NC TraCS, and the Center for Genomics and Society, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068853592"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":0.9653,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.67925478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"342","issue":"4","first_page":"267","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13147","display_name":"Ethics and bioethics in healthcare","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/informed-consent","display_name":"informed consent","score":1.0},{"id":"https://openalex.org/keywords/human-subjects-research","display_name":"human subjects research","score":0.7179999947547913},{"id":"https://openalex.org/keywords/research-ethics","display_name":"research ethics","score":0.8889999985694885},{"id":"https://openalex.org/keywords/clinical-and-translational-research","display_name":"clinical and translational research","score":0.9039999842643738},{"id":"https://openalex.org/keywords/genomic-data-sharing","display_name":"genomic data sharing","score":0.9509999752044678},{"id":"https://openalex.org/keywords/incidental-finding","display_name":"incidental finding","score":0.7369999885559082},{"id":"https://openalex.org/keywords/confidentiality","display_name":"confidentiality","score":0.6579999923706055},{"id":"https://openalex.org/keywords/researcher-researched-relationship","display_name":"researcher-subject relationship","score":0.7480000257492065},{"id":"https://openalex.org/keywords/research-governance","display_name":"research governance","score":0.796999990940094},{"id":"https://openalex.org/keywords/federal-regulation-of-research","display_name":"federal research regulations","score":0.4560000002384186},{"id":"https://openalex.org/keywords/voluntary-participation","display_name":"voluntary participation","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C68122502","wikidata":"https://www.wikidata.org/wiki/Q764527","display_name":"Informed consent","level":3,"score":0.8265243768692017},{"id":"https://openalex.org/C71745522","wikidata":"https://www.wikidata.org/wiki/Q2476929","display_name":"Confidentiality","level":2,"score":0.8130176067352295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5952076315879822},{"id":"https://openalex.org/C2779965156","wikidata":"https://www.wikidata.org/wiki/Q5227350","display_name":"Data sharing","level":3,"score":0.5727211236953735},{"id":"https://openalex.org/C39389867","wikidata":"https://www.wikidata.org/wiki/Q380767","display_name":"Corporate governance","level":2,"score":0.45639723539352417},{"id":"https://openalex.org/C39549134","wikidata":"https://www.wikidata.org/wiki/Q133080","display_name":"Public relations","level":1,"score":0.44796493649482727},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.4131090044975281},{"id":"https://openalex.org/C153997805","wikidata":"https://www.wikidata.org/wiki/Q42240","display_name":"Research ethics","level":2,"score":0.4114251434803009},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.410919725894928},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.20047327876091003},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.1990097165107727},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.19453778862953186},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.18104860186576843},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10014760494232178},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07840397953987122},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007258","descriptor_name":"Informed Consent","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D007258","descriptor_name":"Informed Consent","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026688","descriptor_name":"Bioethical Issues","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040261","descriptor_name":"Harm Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000941","qualifier_name":"ethics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/maj.0b013e31822a6c47","doi":"https://doi.org/10.1097/maj.0b013e31822a6c47","is_oa":false,"landing_page_url":"https://doi.org/10.1097/maj.0b013e31822a6c47","pdf_url":null,"source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},{"id":"pmid:21817873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21817873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of the medical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/1015579","doi":null,"is_oa":false,"landing_page_url":"http://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Is+informed+consent+broken?&title=The+American+journal+of+the+medical+sciences+&volume=342&issue=4&date=2011-10&au=Henderson,+Gail+E","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:340779","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Peace, justice, and strong institutions","score":0.5473999977111816,"id":"https://metadata.un.org/sdg/16"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3647287880","display_name":"Center for Genomics and Society","funder_award_id":"P50HG004488","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6335905122","display_name":"Social Construction of Benefit in Gene Transfer Research","funder_award_id":"R01HG002087","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W116793657","https://openalex.org/W119301680","https://openalex.org/W186149368","https://openalex.org/W191243729","https://openalex.org/W1526383603","https://openalex.org/W1601570956","https://openalex.org/W1819152373","https://openalex.org/W1831547793","https://openalex.org/W1979283835","https://openalex.org/W1983973208","https://openalex.org/W1985053390","https://openalex.org/W1997367676","https://openalex.org/W2005634164","https://openalex.org/W2010680318","https://openalex.org/W2034786591","https://openalex.org/W2035271101","https://openalex.org/W2037283500","https://openalex.org/W2040228409","https://openalex.org/W2043449435","https://openalex.org/W2049240198","https://openalex.org/W2049324928","https://openalex.org/W2049364923","https://openalex.org/W2052235054","https://openalex.org/W2056478869","https://openalex.org/W2063968189","https://openalex.org/W2064037665","https://openalex.org/W2071483390","https://openalex.org/W2076000709","https://openalex.org/W2079434798","https://openalex.org/W2087089820","https://openalex.org/W2093002716","https://openalex.org/W2094277584","https://openalex.org/W2111055529","https://openalex.org/W2112367818","https://openalex.org/W2118344697","https://openalex.org/W2119515435","https://openalex.org/W2120841701","https://openalex.org/W2127047715","https://openalex.org/W2133650606","https://openalex.org/W2140911647","https://openalex.org/W2144851197","https://openalex.org/W2147892763","https://openalex.org/W2170266254","https://openalex.org/W2235691012","https://openalex.org/W2497721881","https://openalex.org/W2726799618","https://openalex.org/W4253610392","https://openalex.org/W4388091429","https://openalex.org/W4388359640"],"related_works":["https://openalex.org/W2794529657","https://openalex.org/W2044196803","https://openalex.org/W4210516021","https://openalex.org/W7097987352","https://openalex.org/W2956753039","https://openalex.org/W2080983631","https://openalex.org/W2105583129","https://openalex.org/W2903214213","https://openalex.org/W2129110146","https://openalex.org/W2156908711"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}