{"id":"https://openalex.org/W2005462392","doi":"https://doi.org/10.1101/gad.8.12.1434","title":"Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.","display_name":"Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.","publication_year":1994,"publication_date":"1994-06-15","ids":{"openalex":"https://openalex.org/W2005462392","doi":"https://doi.org/10.1101/gad.8.12.1434","mag":"2005462392","pmid":"https://pubmed.ncbi.nlm.nih.gov/7926743"},"language":"en","primary_location":{"id":"doi:10.1101/gad.8.12.1434","doi":"https://doi.org/10.1101/gad.8.12.1434","is_oa":false,"landing_page_url":"https://doi.org/10.1101/gad.8.12.1434","pdf_url":null,"source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005462392"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D L Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Turner","raw_affiliation_strings":["Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113590900","display_name":"Harold M. Weintraub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Weintraub","raw_affiliation_strings":["Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","Howard Hughes Medical Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1020,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"12","first_page":"1434","last_page":"1447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proneural-genes","display_name":"proneural genes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neural-induction","display_name":"neural induction","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.6790000200271606},{"id":"https://openalex.org/keywords/epidermal-cells","display_name":"epidermal cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/xenopus-embryo","display_name":"Xenopus embryo","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.5989999771118164},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9581201076507568},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.7654221653938293},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.7333604693412781},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7239767909049988},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7021095752716064},{"id":"https://openalex.org/C197849852","wikidata":"https://www.wikidata.org/wiki/Q2314823","display_name":"Neural plate","level":4,"score":0.6374366283416748},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.5973074436187744},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5700761079788208},{"id":"https://openalex.org/C103607123","wikidata":"https://www.wikidata.org/wiki/Q7002059","display_name":"Neural fold","level":5,"score":0.5654405355453491},{"id":"https://openalex.org/C39961270","wikidata":"https://www.wikidata.org/wiki/Q2927095","display_name":"Neuroblast","level":3,"score":0.46317747235298157},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.41801905632019043},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.36618858575820923},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32419151067733765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29168790578842163},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.26700538396835327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.178018718957901},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.15985268354415894}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004475","descriptor_name":"Ectoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005775","descriptor_name":"Gastrula","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1101/gad.8.12.1434","doi":"https://doi.org/10.1101/gad.8.12.1434","is_oa":false,"landing_page_url":"https://doi.org/10.1101/gad.8.12.1434","pdf_url":null,"source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes &amp; Development","raw_type":"journal-article"},{"id":"pmid:7926743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7926743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W88921046","https://openalex.org/W125898244","https://openalex.org/W1560143429","https://openalex.org/W1589317498","https://openalex.org/W1643332474","https://openalex.org/W1676377677","https://openalex.org/W1762303456","https://openalex.org/W1801955451","https://openalex.org/W1826524642","https://openalex.org/W1874287342","https://openalex.org/W1920825899","https://openalex.org/W1926789599","https://openalex.org/W1934988433","https://openalex.org/W1966387132","https://openalex.org/W1967192173","https://openalex.org/W1968198246","https://openalex.org/W1973546377","https://openalex.org/W1974543599","https://openalex.org/W1986380537","https://openalex.org/W1996971076","https://openalex.org/W1999529317","https://openalex.org/W2001912359","https://openalex.org/W2005321694","https://openalex.org/W2010206624","https://openalex.org/W2012133306","https://openalex.org/W2013002081","https://openalex.org/W2016314596","https://openalex.org/W2018485286","https://openalex.org/W2019855402","https://openalex.org/W2020945977","https://openalex.org/W2021181211","https://openalex.org/W2022556470","https://openalex.org/W2025804504","https://openalex.org/W2027620926","https://openalex.org/W2029142481","https://openalex.org/W2037097175","https://openalex.org/W2038158007","https://openalex.org/W2043408306","https://openalex.org/W2044845657","https://openalex.org/W2047165320","https://openalex.org/W2047488088","https://openalex.org/W2048899280","https://openalex.org/W2056050429","https://openalex.org/W2056069458","https://openalex.org/W2056643758","https://openalex.org/W2064049283","https://openalex.org/W2077881308","https://openalex.org/W2078718449","https://openalex.org/W2080592158","https://openalex.org/W2081424815","https://openalex.org/W2083680504","https://openalex.org/W2087126781","https://openalex.org/W2091223115","https://openalex.org/W2108490725","https://openalex.org/W2125619554","https://openalex.org/W2128678520","https://openalex.org/W2129978661","https://openalex.org/W2134721282","https://openalex.org/W2143759777","https://openalex.org/W2143965788","https://openalex.org/W2147975813","https://openalex.org/W2157416798","https://openalex.org/W2157740912","https://openalex.org/W2159511823","https://openalex.org/W2171329030","https://openalex.org/W2184358607","https://openalex.org/W2239760782","https://openalex.org/W2340477458","https://openalex.org/W2341901469","https://openalex.org/W2419282219","https://openalex.org/W4243279772","https://openalex.org/W4295602831"],"related_works":["https://openalex.org/W2169746174","https://openalex.org/W2022556470","https://openalex.org/W2138122506","https://openalex.org/W2401342671","https://openalex.org/W2089976301","https://openalex.org/W1967192173","https://openalex.org/W2171329030","https://openalex.org/W2087106852","https://openalex.org/W2119447145"],"abstract_inverted_index":{"In":[0],"Drosophila,":[1],"the":[2,6,60,63,140,158],"proneural":[3],"genes":[4],"of":[5,38,59,65,70,109,126,139,161],"achaete-scute":[7,27],"complex":[8],"encode":[9],"transcriptional":[10],"activators":[11],"that":[12,81,113],"can":[13],"commit":[14],"cells":[15,79,132],"to":[16,95,133,147,157],"a":[17,36,134],"neural":[18,77,88,97,128,135],"fate.":[19,136],"We":[20],"have":[21],"isolated":[22],"cDNAs":[23],"for":[24,73],"two":[25],"Xenopus":[26,54],"homologs,":[28],"ASH3a":[29],"and":[30,76,130],"ASH3b,":[31],"which":[32],"are":[33],"expressed":[34],"in":[35,52,104],"subset":[37],"central":[39],"nervous":[40],"system":[41],"(CNS)":[42],"neuroblasts":[43],"during":[44],"early":[45,86,141],"neurogenesis.":[46],"After":[47],"expressing":[48],"either":[49],"ASH3":[50,151],"protein":[51],"developing":[53],"embryos,":[55],"we":[56],"find":[57],"enlargement":[58,93],"CNS":[61,82,92,115],"at":[62],"expense":[64],"adjacent":[66],"non-neural":[67],"ectoderm.":[68],"Analysis":[69],"molecular":[71],"markers":[72],"neural,":[74],"epidermal,":[75],"crest":[78,129],"indicates":[80],"expansion":[83],"occurs":[84],"as":[85,87,99],"plate":[89],"formation.":[90],"ASH3-dependent":[91],"appears":[94],"require":[96],"induction,":[98],"it":[100,123],"does":[101,117],"not":[102,118],"occur":[103],"animal":[105],"cap":[106],"explants.":[107],"Inhibition":[108],"DNA":[110],"synthesis":[111],"shows":[112],"additional":[114],"tissue":[116],"depend":[119],"on":[120],"cell":[121],"division--rather":[122],"reflects":[124],"conversion":[125],"prospective":[127],"epidermal":[131],"The":[137],"differentiation":[138],"forming":[142],"primary":[143],"neurons":[144],"also":[145],"seems":[146],"be":[148,155],"prevented":[149],"by":[150,164],"expression.":[152],"This":[153],"may":[154],"secondary":[156],"observed":[159],"activation":[160],"Xotch":[162],"transcription":[163],"ASH3.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
