{"id":"https://openalex.org/W2005461184","doi":"https://doi.org/10.1021/ac9028483","title":"Conductometric Method for the Rapid Characterization of the Substrate Specificity of Amine-Transaminases","display_name":"Conductometric Method for the Rapid Characterization of the Substrate Specificity of Amine-Transaminases","publication_year":2010,"publication_date":"2010-02-11","ids":{"openalex":"https://openalex.org/W2005461184","doi":"https://doi.org/10.1021/ac9028483","mag":"2005461184","pmid":"https://pubmed.ncbi.nlm.nih.gov/20148590"},"language":"en","primary_location":{"id":"doi:10.1021/ac9028483","doi":"https://doi.org/10.1021/ac9028483","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac9028483","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065028482","display_name":"Sebastian Sch\u00e4tzle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Sch\u00e4tzle","raw_affiliation_strings":["Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004420169","display_name":"Matthias H\u00f6hne","orcid":"https://orcid.org/0000-0002-2542-725X","observed_orcids":["https://orcid.org/0000-0002-2542-725X"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias H\u00f6hne","raw_affiliation_strings":["Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009737194","display_name":"Karen T. Robins","orcid":"https://orcid.org/0000-0003-0484-2734","observed_orcids":["https://orcid.org/0000-0003-0484-2734"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Robins","raw_affiliation_strings":["Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031181844","display_name":"Uwe T. Bornscheuer","orcid":"https://orcid.org/0000-0003-0685-2696","observed_orcids":["https://orcid.org/0000-0003-0685-2696"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Uwe T. Bornscheuer","raw_affiliation_strings":["Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff-Strasse 4, 17487 Greifswald, Germany, and Lonza AG, Valais Works, Visp, Switzerland","institution_ids":["https://openalex.org/I36522303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031181844"],"corresponding_institution_ids":["https://openalex.org/I36522303"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6372,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.62005618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"82","issue":"5","first_page":"2082","last_page":"2086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amine-transaminase","display_name":"amine transaminase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/omega-transaminase","display_name":"omega-transaminase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.718999981880188},{"id":"https://openalex.org/keywords/pyridoxal-phosphate-dependent-enzymes","display_name":"pyridoxal phosphate-dependent enzymes","score":0.9319999814033508},{"id":"https://openalex.org/keywords/transamination","display_name":"transamination","score":0.5550000071525574},{"id":"https://openalex.org/keywords/rhodobacter-sphaeroides","display_name":"Rhodobacter sphaeroides","score":0.9309999942779541},{"id":"https://openalex.org/keywords/alpha-methylbenzylamine","display_name":"\u03b1-methylbenzylamine","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9213677048683167},{"id":"https://openalex.org/C68793091","wikidata":"https://www.wikidata.org/wiki/Q603891","display_name":"Transamination","level":3,"score":0.862485945224762},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.7632148265838623},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6799447536468506},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5744381546974182},{"id":"https://openalex.org/C2777738585","wikidata":"https://www.wikidata.org/wiki/Q170744","display_name":"Ketone","level":2,"score":0.4517402946949005},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.42609280347824097},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41900497674942017},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.37744075059890747},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3758469521999359},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18863829970359802},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000637","descriptor_name":"Transaminases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac9028483","doi":"https://doi.org/10.1021/ac9028483","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac9028483","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:20148590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20148590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1512574750","https://openalex.org/W1999944248","https://openalex.org/W2013582042","https://openalex.org/W2024851405","https://openalex.org/W2036184150","https://openalex.org/W2039048594","https://openalex.org/W2055271799","https://openalex.org/W2056812552","https://openalex.org/W2057109554","https://openalex.org/W2074133083","https://openalex.org/W2080253061","https://openalex.org/W2098559192","https://openalex.org/W2163872054","https://openalex.org/W4241267853"],"related_works":["https://openalex.org/W2024851405","https://openalex.org/W2945163106","https://openalex.org/W3175980832","https://openalex.org/W2508088955","https://openalex.org/W2765820592","https://openalex.org/W4309245639","https://openalex.org/W4389964041","https://openalex.org/W3040737869","https://openalex.org/W2036341269","https://openalex.org/W4295181040"],"abstract_inverted_index":{"Amine-transaminases":[0],"(ATAs,":[1],"omega-transaminases,":[2],"omega-TA)":[3],"are":[4,23,51,129],"PLP-dependent":[5],"enzymes":[6],"that":[7],"catalyze":[8],"amino":[9,20,84,98,140],"group":[10],"transfer":[11],"reactions.":[12],"In":[13,158],"contrast":[14,159],"to":[15,25,131,153,160],"the":[16,43,58,72,75,80,83,97,116,147,182,196,205],"widespread":[17],"and":[18,123,137,174,204],"well-known":[19],"acid-transaminases,":[21],"ATAs":[22],"able":[24],"convert":[26],"substrates":[27],"lacking":[28],"an":[29,108,185],"alpha-carboxylic":[30],"functional":[31],"group.":[32],"They":[33],"have":[34],"gained":[35],"increased":[36],"attention":[37],"because":[38],"of":[39,46,60,74,82,101,107,144,198],"their":[40],"potential":[41],"for":[42,57,79,95,146,184,195],"asymmetric":[44],"synthesis":[45],"optically":[47],"active":[48],"amines,":[49],"which":[50],"frequently":[52],"used":[53,194],"as":[54],"building":[55],"blocks":[56],"preparation":[59],"numerous":[61],"pharmaceuticals.":[62],"Having":[63],"already":[64],"introduced":[65],"a":[66,91,102,119,124,134,138,199],"fast":[67],"kinetic":[68,92],"assay":[69,94,192],"based":[70],"on":[71,90],"conversion":[73],"model":[76],"substrate":[77],"alpha-methylbenzylamine":[78],"characterization":[81,197],"acceptor":[85],"specificity,":[86],"we":[87],"now":[88],"report":[89],"conductivity":[93,145],"investigating":[96],"donor":[99],"specificity":[100],"given":[103],"ATA.":[104],"The":[105,142,191],"course":[106],"ATA-catalyzed":[109],"reaction":[110,149],"can":[111,178],"be":[112,154,179],"followed":[113],"conductometrically":[114],"since":[115],"conducting":[117],"substrates,":[118],"positively":[120],"charged":[121,126],"amine":[122,173],"negatively":[125],"keto":[127,176],"acid,":[128],"converted":[130],"nonconducting":[132],"products,":[133],"noncharged":[135],"ketone":[136],"zwitterionic":[139],"acid.":[141],"decrease":[143],"investigated":[148],"systems":[150],"were":[151,208],"determined":[152],"33-52":[155],"microS":[156],"mM(-1).":[157],"other":[161],"ATA-assays":[162],"previously":[163],"described,":[164],"with":[165,212],"this":[166],"approach":[167],"all":[168],"transamination":[169],"reactions":[170],"between":[171],"any":[172,175],"acid":[177],"monitored":[180],"without":[181],"need":[183],"additional":[186],"enzyme":[187],"or":[188],"staining":[189],"solutions.":[190],"was":[193],"ATA":[200],"from":[201],"Rhodobacter":[202],"sphaeroides,":[203],"data":[206],"obtained":[207],"in":[209],"excellent":[210],"agreement":[211],"gas":[213],"chromatography":[214],"analysis.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
