{"id":"https://openalex.org/W2005453961","doi":"https://doi.org/10.1016/0006-8993(78)90562-0","title":"Pre- and postsynaptic neurochemical alterations in Alzheimer's disease","display_name":"Pre- and postsynaptic neurochemical alterations in Alzheimer's disease","publication_year":1978,"publication_date":"1978-12-01","ids":{"openalex":"https://openalex.org/W2005453961","doi":"https://doi.org/10.1016/0006-8993(78)90562-0","mag":"2005453961","pmid":"https://pubmed.ncbi.nlm.nih.gov/215272"},"language":"en","primary_location":{"id":"doi:10.1016/0006-8993(78)90562-0","doi":"https://doi.org/10.1016/0006-8993(78)90562-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(78)90562-0","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005453961"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086196539","display_name":"Terry Reisine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry D. Reisine","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz. 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz. 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112699372","display_name":"Henry I. Yamamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry I. Yamamura","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz. 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of Arizona Health Sciences Center, Tucson, Ariz. 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103461455","display_name":"Edward D. Bird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edward D. Bird","raw_affiliation_strings":["Department of Neurological Surgery and Neurology, Addenbrookes Hospital, Cambridge, Great Britain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery and Neurology, Addenbrookes Hospital, Cambridge, Great Britain","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111633436","display_name":"Ernest G. Spokes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ernest Spokes","raw_affiliation_strings":["Department of Neurological Surgery and Neurology, Addenbrookes Hospital, Cambridge, Great Britain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery and Neurology, Addenbrookes Hospital, Cambridge, Great Britain","institution_ids":["https://openalex.org/I4210156194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109572909","display_name":"S.J. Enna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.J. Enna","raw_affiliation_strings":["Departments of Pharmacology, Neurobiology and and Anatomy, University of Texas Medical School at Houston, P.O. Box 20708, Houston Texas 77025, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Neurobiology and and Anatomy, University of Texas Medical School at Houston, P.O. Box 20708, Houston Texas 77025, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":7.5161,"has_fulltext":false,"cited_by_count":339,"citation_normalized_percentile":{"value":0.98463975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"159","issue":"2","first_page":"477","last_page":"481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.8460000157356262},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-pathology","display_name":"amyloid-beta pathology","score":0.8840000033378601},{"id":"https://openalex.org/keywords/prongf","display_name":"proNGF","score":0.7319999933242798},{"id":"https://openalex.org/keywords/protease-cascade","display_name":"protease cascade","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cholinergic-synapses","display_name":"cholinergic synapses","score":0.9169999957084656},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cortical-cholinergic-neurons","display_name":"cortical cholinergic neurons","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7171238660812378},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.7014586925506592},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.6777284145355225},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6319049000740051},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5887810587882996},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.5775268077850342},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5574594736099243},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47280922532081604},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.46465033292770386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4635196626186371},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.4352347254753113},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.40067678689956665},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39077574014663696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3579409122467041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17858722805976868},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1284780204296112},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07710060477256775}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002421","descriptor_name":"Caudate Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002795","descriptor_name":"Choline O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013134","descriptor_name":"Spiperone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-8993(78)90562-0","doi":"https://doi.org/10.1016/0006-8993(78)90562-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(78)90562-0","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:215272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/215272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1973087242","https://openalex.org/W1995877432","https://openalex.org/W1996649288","https://openalex.org/W1997120605","https://openalex.org/W2017475744","https://openalex.org/W2024552179","https://openalex.org/W2028257119","https://openalex.org/W2054658543","https://openalex.org/W2073766363","https://openalex.org/W2078719291","https://openalex.org/W2090002988","https://openalex.org/W2104227586","https://openalex.org/W2110765139","https://openalex.org/W2111052533","https://openalex.org/W2115250531","https://openalex.org/W2181316650","https://openalex.org/W6685900004"],"related_works":["https://openalex.org/W2752646801","https://openalex.org/W2766358487","https://openalex.org/W2954998030","https://openalex.org/W7117149833","https://openalex.org/W2118356251","https://openalex.org/W3029938902","https://openalex.org/W990083831","https://openalex.org/W2009916013","https://openalex.org/W2002496882","https://openalex.org/W2087655177"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
