{"id":"https://openalex.org/W2005451662","doi":"https://doi.org/10.1016/j.ydbio.2008.12.028","title":"Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5","display_name":"Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5","publication_year":2009,"publication_date":"2009-01-04","ids":{"openalex":"https://openalex.org/W2005451662","doi":"https://doi.org/10.1016/j.ydbio.2008.12.028","mag":"2005451662","pmid":"https://pubmed.ncbi.nlm.nih.gov/19166829"},"language":"en","primary_location":{"id":"doi:10.1016/j.ydbio.2008.12.028","doi":"https://doi.org/10.1016/j.ydbio.2008.12.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2008.12.028","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160608014504/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0012160608014504/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078197547","display_name":"Ram\u00f3n A. Espinoza\u2010Lewis","orcid":"https://orcid.org/0000-0003-3068-5517","observed_orcids":["https://orcid.org/0000-0003-3068-5517"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram\u00f3n A. Espinoza-Lewis","raw_affiliation_strings":["Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681417","display_name":"Ling Dan Yu","orcid":"https://orcid.org/0000-0002-6726-281X","observed_orcids":["https://orcid.org/0000-0002-6726-281X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Yu","raw_affiliation_strings":["Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002695881","display_name":"Fenglei He","orcid":"https://orcid.org/0000-0003-4717-8001","observed_orcids":["https://orcid.org/0000-0003-4717-8001"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fenglei He","raw_affiliation_strings":["Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100599490","display_name":"Hongbing Liu","orcid":"https://orcid.org/0000-0002-3411-4597","observed_orcids":["https://orcid.org/0000-0002-3411-4597"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbing Liu","raw_affiliation_strings":["Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074041207","display_name":"Ruhang Tang","orcid":"https://orcid.org/0000-0003-4918-3525","observed_orcids":["https://orcid.org/0000-0003-4918-3525"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruhang Tang","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA","Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077029721","display_name":"Jiangli Shi","orcid":"https://orcid.org/0000-0002-1121-6742","observed_orcids":["https://orcid.org/0000-0002-1121-6742"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangli Shi","raw_affiliation_strings":["Center for Cell and Developmental Biology, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Developmental Biology, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056197830","display_name":"Xiaoxiao Sun","orcid":"https://orcid.org/0000-0002-9689-9385","observed_orcids":["https://orcid.org/0000-0002-9689-9385"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxiao Sun","raw_affiliation_strings":["Alkek Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkek Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080982128","display_name":"James F. Martin","orcid":"https://orcid.org/0000-0002-7842-9857","observed_orcids":["https://orcid.org/0000-0002-7842-9857"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James F. Martin","raw_affiliation_strings":["Alkek Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alkek Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I125029298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100740247","display_name":"Da\u2010Zhi Wang","orcid":"https://orcid.org/0000-0003-1774-6549","observed_orcids":["https://orcid.org/0000-0003-1774-6549"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dazhi Wang","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA","Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031540238","display_name":"Jing Yang","orcid":"https://orcid.org/0000-0002-4983-1660","observed_orcids":["https://orcid.org/0000-0002-4983-1660","https://orcid.org/0000-0001-5975-4315"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Center for Cell and Developmental Biology, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cell and Developmental Biology, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100374687","display_name":"Yiping Chen","orcid":"https://orcid.org/0000-0002-8628-7713","observed_orcids":["https://orcid.org/0000-0002-8628-7713"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"YiPing Chen","raw_affiliation_strings":["Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Cell & Molecular Biology, Tulane University, New Orleans, LA, 70118, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100374687"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":4.5583,"has_fulltext":true,"cited_by_count":241,"citation_normalized_percentile":{"value":0.95710603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"327","issue":"2","first_page":"376","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shox2","display_name":"SHOX2","score":1.0},{"id":"https://openalex.org/keywords/nkx2-5","display_name":"Nkx2.5","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pacemaker-cells","display_name":"pacemaker cells","score":0.7730000019073486},{"id":"https://openalex.org/keywords/homeodomain-transcription-factor","display_name":"homeodomain transcription factor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9279999732971191},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sinus-venosus","display_name":"sinus venosus","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tbx3","display_name":"TBX3","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hcn4","display_name":"HCN4","score":0.996999979019165},{"id":"https://openalex.org/keywords/embryonic-heart-development","display_name":"embryonic heart development","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.7906889915466309},{"id":"https://openalex.org/C2778542873","wikidata":"https://www.wikidata.org/wiki/Q286020","display_name":"Sinoatrial node","level":4,"score":0.7538188099861145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7218829989433289},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.6532315015792847},{"id":"https://openalex.org/C2779617070","wikidata":"https://www.wikidata.org/wiki/Q4739730","display_name":"Sinus venosus","level":2,"score":0.5284200310707092},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5266960859298706},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5133368372917175},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5039095282554626},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.4549131691455841},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44448211789131165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3873429000377655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3492320775985718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3211100101470947},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2953571081161499},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2492143213748932},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22775888442993164},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.18061351776123047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14518219232559204},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072576","descriptor_name":"Homeobox Protein Nkx-2.5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072576","descriptor_name":"Homeobox Protein Nkx-2.5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072576","descriptor_name":"Homeobox Protein Nkx-2.5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072576","descriptor_name":"Homeobox Protein Nkx-2.5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ydbio.2008.12.028","doi":"https://doi.org/10.1016/j.ydbio.2008.12.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2008.12.028","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160608014504/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},{"id":"pmid:19166829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19166829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental biology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:h989r9189","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/w8r4-z219","pdf_url":"https://cdr.lib.unc.edu/downloads/f4752q07r","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Developmental Biology, 327(2)","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2694185","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2694185","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dev Biol","raw_type":"Text"},{"id":"doi:10.17615/w8r4-z219","doi":"https://doi.org/10.17615/w8r4-z219","is_oa":true,"landing_page_url":"https://doi.org/10.17615/w8r4-z219","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1016/j.ydbio.2008.12.028","doi":"https://doi.org/10.1016/j.ydbio.2008.12.028","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ydbio.2008.12.028","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0012160608014504/pdf","source":{"id":"https://openalex.org/S136634221","display_name":"Developmental Biology","issn_l":"0012-1606","issn":["0012-1606","1095-564X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1096910460","display_name":null,"funder_award_id":"R01 DE014044","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G1760010046","display_name":null,"funder_award_id":"R01 DE16329-01","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3676446816","display_name":null,"funder_award_id":"R01 HL085635","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G415001556","display_name":null,"funder_award_id":"R01 DE14044","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5706495840","display_name":null,"funder_award_id":"0340166N","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8371714809","display_name":"PITX2 AND WNT'S IN CRANIOFACIAL DEVELOPMENT","funder_award_id":"R01DE016329","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000083621","display_name":null,"funder_award_id":"R01DE14044","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005451662.pdf","grobid_xml":"https://content.openalex.org/works/W2005451662.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1494350196","https://openalex.org/W1518173022","https://openalex.org/W1520697307","https://openalex.org/W1567904175","https://openalex.org/W1596115288","https://openalex.org/W1826994112","https://openalex.org/W1918440328","https://openalex.org/W1965266041","https://openalex.org/W1972220884","https://openalex.org/W1972705904","https://openalex.org/W1975874715","https://openalex.org/W1979854824","https://openalex.org/W1982357288","https://openalex.org/W1984634814","https://openalex.org/W1984960456","https://openalex.org/W1994596418","https://openalex.org/W1997267758","https://openalex.org/W2004537703","https://openalex.org/W2004876851","https://openalex.org/W2005264220","https://openalex.org/W2008142951","https://openalex.org/W2010390017","https://openalex.org/W2010854221","https://openalex.org/W2022753132","https://openalex.org/W2023001234","https://openalex.org/W2024353183","https://openalex.org/W2027593708","https://openalex.org/W2037002100","https://openalex.org/W2040686597","https://openalex.org/W2040836037","https://openalex.org/W2043887934","https://openalex.org/W2045456469","https://openalex.org/W2045923054","https://openalex.org/W2058847745","https://openalex.org/W2066556421","https://openalex.org/W2071492647","https://openalex.org/W2075563634","https://openalex.org/W2076600697","https://openalex.org/W2080152736","https://openalex.org/W2085774451","https://openalex.org/W2086519742","https://openalex.org/W2092389279","https://openalex.org/W2093494317","https://openalex.org/W2096751146","https://openalex.org/W2097246504","https://openalex.org/W2102254218","https://openalex.org/W2111031333","https://openalex.org/W2112259501","https://openalex.org/W2114556828","https://openalex.org/W2115599237","https://openalex.org/W2121052817","https://openalex.org/W2123358624","https://openalex.org/W2124668407","https://openalex.org/W2125574476","https://openalex.org/W2126222193","https://openalex.org/W2132285073","https://openalex.org/W2134626110","https://openalex.org/W2140010152","https://openalex.org/W2147839272","https://openalex.org/W2151885701","https://openalex.org/W2155127083","https://openalex.org/W2155246478","https://openalex.org/W2157381937","https://openalex.org/W2165340969","https://openalex.org/W2165525253","https://openalex.org/W2166669288","https://openalex.org/W2168881898","https://openalex.org/W2234326338","https://openalex.org/W2328269288","https://openalex.org/W2402853450","https://openalex.org/W3189837171","https://openalex.org/W4387737657","https://openalex.org/W6638552287"],"related_works":["https://openalex.org/W2142432925","https://openalex.org/W1444453965","https://openalex.org/W105305539","https://openalex.org/W2150592964","https://openalex.org/W2926761053","https://openalex.org/W2311415470","https://openalex.org/W2113762080","https://openalex.org/W1498853927","https://openalex.org/W2129156306","https://openalex.org/W2188832683"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}