{"id":"https://openalex.org/W2005449591","doi":"https://doi.org/10.2165/00003088-198207050-00003","title":"Clinical Pharmacokinetics of Pethidine","display_name":"Clinical Pharmacokinetics of Pethidine","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2005449591","doi":"https://doi.org/10.2165/00003088-198207050-00003","mag":"2005449591","pmid":"https://pubmed.ncbi.nlm.nih.gov/6754208"},"language":"en","primary_location":{"id":"doi:10.2165/00003088-198207050-00003","doi":"https://doi.org/10.2165/00003088-198207050-00003","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-198207050-00003","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101874278","display_name":"David J. Edwards","orcid":"https://orcid.org/0000-0002-5039-8243","observed_orcids":["https://orcid.org/0000-0002-5039-8243"]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Edwards","raw_affiliation_strings":["Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033741905","display_name":"Craig K. Svensson","orcid":"https://orcid.org/0000-0001-6841-075X","observed_orcids":["https://orcid.org/0000-0001-6841-075X"]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig K. Svensson","raw_affiliation_strings":["Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016820216","display_name":"John P. Visco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Visco","raw_affiliation_strings":["Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027629687","display_name":"David Lalka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157091","display_name":"Buffalo General Medical Center","ror":"https://ror.org/04ngv0f69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130","https://openalex.org/I4210157091"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Lalka","raw_affiliation_strings":["Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology and the Clinical Pharmacokinetics Laboratory, Buffalo General Hospital, Buffalo, USA","institution_ids":["https://openalex.org/I4210157091"]},{"raw_affiliation_string":"Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, USA","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":9.0856,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.98223062,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"5","first_page":"421","last_page":"433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.45750001072883606,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.3862000107765198,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.07580000162124634,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meperidine","display_name":"pethidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9129999876022339},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5809999704360962},{"id":"https://openalex.org/keywords/postoperative-analgesia","display_name":"postoperative analgesia","score":0.7770000100135803},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8529999852180481},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.8579999804496765},{"id":"https://openalex.org/keywords/alpha-1-acid-glycoprotein","display_name":"alpha-1-acid glycoprotein","score":0.9110000133514404},{"id":"https://openalex.org/keywords/continuous-intravenous-infusion","display_name":"continuous intravenous infusion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/acute-pain-management","display_name":"acute pain management","score":0.753000020980835},{"id":"https://openalex.org/keywords/blood-clearance","display_name":"blood clearance","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2781168792","wikidata":"https://www.wikidata.org/wiki/Q55434","display_name":"Pethidine","level":3,"score":0.9948115348815918},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7621226906776428},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.7566075325012207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6439878940582275},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6084086894989014},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5152464509010315},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5030173659324646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48044392466545105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2226809859275818}],"mesh":[{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/00003088-198207050-00003","doi":"https://doi.org/10.2165/00003088-198207050-00003","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00003088-198207050-00003","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmid:6754208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6754208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W241012102","https://openalex.org/W1504206986","https://openalex.org/W1508256028","https://openalex.org/W1575402562","https://openalex.org/W1587578206","https://openalex.org/W1679843487","https://openalex.org/W1700225529","https://openalex.org/W1807873557","https://openalex.org/W1910350416","https://openalex.org/W1965487148","https://openalex.org/W1965549499","https://openalex.org/W1965588854","https://openalex.org/W1970039528","https://openalex.org/W1974207620","https://openalex.org/W1981652712","https://openalex.org/W1985002309","https://openalex.org/W1994248696","https://openalex.org/W1997589521","https://openalex.org/W1998514790","https://openalex.org/W2000358986","https://openalex.org/W2004140403","https://openalex.org/W2009782471","https://openalex.org/W2013627543","https://openalex.org/W2015062769","https://openalex.org/W2021468404","https://openalex.org/W2032817891","https://openalex.org/W2038573014","https://openalex.org/W2048426130","https://openalex.org/W2049811985","https://openalex.org/W2051895279","https://openalex.org/W2054169914","https://openalex.org/W2063519287","https://openalex.org/W2064749124","https://openalex.org/W2065423157","https://openalex.org/W2067167613","https://openalex.org/W2070653366","https://openalex.org/W2091400906","https://openalex.org/W2096329451","https://openalex.org/W2098833304","https://openalex.org/W2117246041","https://openalex.org/W2134781827","https://openalex.org/W2142369476","https://openalex.org/W2143447029","https://openalex.org/W2165118050","https://openalex.org/W2244892766","https://openalex.org/W2260970843","https://openalex.org/W2271305117","https://openalex.org/W2292599282","https://openalex.org/W2311442063","https://openalex.org/W2336516640","https://openalex.org/W2347995411","https://openalex.org/W2402940732","https://openalex.org/W2408223685","https://openalex.org/W2410359872","https://openalex.org/W2413511492","https://openalex.org/W2414494194","https://openalex.org/W2416795262","https://openalex.org/W2417721538","https://openalex.org/W2428713294","https://openalex.org/W3003643062"],"related_works":["https://openalex.org/W2044914046","https://openalex.org/W2009782471","https://openalex.org/W1965487148","https://openalex.org/W2014913561","https://openalex.org/W2020855707","https://openalex.org/W2410359872","https://openalex.org/W1807873557","https://openalex.org/W2085307474","https://openalex.org/W2070653366","https://openalex.org/W2049487402"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
