{"id":"https://openalex.org/W2005448700","doi":"https://doi.org/10.1080/00365510701663350","title":"Long\u2010term influence of diet and/or omega\u20103 fatty acids on matrix metalloproteinase\u20109 and pregnancy\u2010associated plasma protein\u2010A in men at high risk of coronary heart disease","display_name":"Long\u2010term influence of diet and/or omega\u20103 fatty acids on matrix metalloproteinase\u20109 and pregnancy\u2010associated plasma protein\u2010A in men at high risk of coronary heart disease","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2005448700","doi":"https://doi.org/10.1080/00365510701663350","mag":"2005448700","pmid":"https://pubmed.ncbi.nlm.nih.gov/17934973"},"language":"en","primary_location":{"id":"doi:10.1080/00365510701663350","doi":"https://doi.org/10.1080/00365510701663350","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365510701663350","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076714371","display_name":"Eline Bredal Furenes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"E. B. Furenes","raw_affiliation_strings":["Center for Clinical Heart Research, Department of Cardiology, Faculty of Medicine, University of Oslo, Oslo, Norway","Center for Clinical Heart Research, Department of Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Heart Research, Department of Cardiology, Faculty of Medicine, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Center for Clinical Heart Research, Department of Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072637485","display_name":"Ingebj\u00f8rg Seljeflot","orcid":"https://orcid.org/0000-0003-4071-3358","observed_orcids":["https://orcid.org/0000-0003-4071-3358"]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"I. Seljeflot","raw_affiliation_strings":["Center for Clinical Heart Research, Department of Cardiology; Center for Clinical Research, Ullevaal University Hospital, Faculty of Medicine University of Oslo, Oslo, Norway","Center for Clinical Heart Research, Department of Cardiology","Center for Clinical Research, Ullevaal University Hospital, Faculty of Medicine University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Heart Research, Department of Cardiology; Center for Clinical Research, Ullevaal University Hospital, Faculty of Medicine University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Center for Clinical Heart Research, Department of Cardiology","institution_ids":[]},{"raw_affiliation_string":"Center for Clinical Research, Ullevaal University Hospital, Faculty of Medicine University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006868417","display_name":"Svein Solheim","orcid":"https://orcid.org/0000-0003-3321-6572","observed_orcids":["https://orcid.org/0000-0003-3321-6572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Solheim","raw_affiliation_strings":["Center for Clinical Heart Research, Department of Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Heart Research, Department of Cardiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065220148","display_name":"Elsa M. Hjerkinn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"E. M. Hjerkinn","raw_affiliation_strings":["Center for Clinical Research, Ullevaal University Hospital, Faculty of Medicine University of Oslo, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Research, Ullevaal University Hospital, Faculty of Medicine University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084461040","display_name":"Harald Arnesen","orcid":"https://orcid.org/0000-0002-0409-8792","observed_orcids":["https://orcid.org/0000-0002-0409-8792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Arnesen","raw_affiliation_strings":["Center for Clinical Heart Research, Department of Cardiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Heart Research, Department of Cardiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0982,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.10086957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"68","issue":"3","first_page":"177","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.07540000230073929,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/papp-a","display_name":"PAPP-A","score":0.9750000238418579},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/n-3-pufa-supplementation","display_name":"n-3 PUFA supplementation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nutrition-counseling","display_name":"nutrition counseling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/coronary-heart-disease-risk","display_name":"coronary heart disease risk","score":0.8040000200271606},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/carotid-intima-media-thickness","display_name":"carotid intima-media thickness","score":0.9419999718666077},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.996999979019165},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6791630983352661},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.650713324546814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6432454586029053},{"id":"https://openalex.org/C2778014424","wikidata":"https://www.wikidata.org/wiki/Q1476411","display_name":"Pregnancy-associated plasma protein A","level":5,"score":0.583717405796051},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5429274439811707},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5370392203330994},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.516767144203186},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5164294838905334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4931456446647644},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3360852301120758},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.20427322387695312},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16677317023277283},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.16330179572105408},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08067122101783752},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C3019714739","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"First trimester","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011266","descriptor_name":"Pregnancy-Associated Plasma Protein-A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011266","descriptor_name":"Pregnancy-Associated Plasma Protein-A","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/00365510701663350","doi":"https://doi.org/10.1080/00365510701663350","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365510701663350","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:17934973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17934973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of clinical and laboratory investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1839106303","https://openalex.org/W1872982664","https://openalex.org/W1966839503","https://openalex.org/W1967514197","https://openalex.org/W1970138556","https://openalex.org/W1970612537","https://openalex.org/W1979713467","https://openalex.org/W1983531379","https://openalex.org/W1986967430","https://openalex.org/W1991685386","https://openalex.org/W2000116995","https://openalex.org/W2017429999","https://openalex.org/W2021875072","https://openalex.org/W2030042443","https://openalex.org/W2037967088","https://openalex.org/W2040513126","https://openalex.org/W2048659949","https://openalex.org/W2049767734","https://openalex.org/W2078931357","https://openalex.org/W2094941678","https://openalex.org/W2095605519","https://openalex.org/W2099019831","https://openalex.org/W2099075814","https://openalex.org/W2100736445","https://openalex.org/W2125711853","https://openalex.org/W2125930919","https://openalex.org/W2135981842","https://openalex.org/W2137742731","https://openalex.org/W2142570339","https://openalex.org/W2153224796","https://openalex.org/W2154870951","https://openalex.org/W2159087408","https://openalex.org/W2162994975","https://openalex.org/W2168526937","https://openalex.org/W2184483218","https://openalex.org/W2192223169","https://openalex.org/W2324841714","https://openalex.org/W2417745655","https://openalex.org/W2467019940"],"related_works":["https://openalex.org/W2099019831","https://openalex.org/W2050290821","https://openalex.org/W7099861960","https://openalex.org/W2029428504","https://openalex.org/W2151720242","https://openalex.org/W7100231514","https://openalex.org/W2033737104","https://openalex.org/W7172309441","https://openalex.org/W2062630574","https://openalex.org/W2888756436"],"abstract_inverted_index":{"BACKGROUND:":[0],"Matrix":[1],"metalloproteinases":[2],"(MMPs)":[3],"are":[4,28],"important":[5],"in":[6,67,121,154,164,179,187,197,219],"the":[7,38,53,87,147,182,198,212,220],"atherosclerotic":[8],"process.":[9],"The":[10,174],"relationship":[11],"between":[12,89,146],"MMPs":[13,196],"and":[14,22,62,92,101,116,135,150,156,181],"traditional":[15,102],"risk":[16,75,103],"factors":[17,104],"for":[18,105],"cardiovascular":[19],"disease":[20,94],"(CVD)":[21],"any":[23],"influence":[24,211],"of":[25,40,43,55,59,70,76,113,177,185,195,200,214],"lifestyle":[26],"changes":[27],"largely":[29],"unknown.":[30],"OBJECTIVES:":[31],"In":[32],"a":[33,68],"factorial":[34],"design,":[35],"we":[36],"studied":[37],"effects":[39],"3":[41],"years":[42],"dietary":[44],"counselling":[45],"and/or":[46,205],"n-3":[47,206],"PUFA":[48,207],"supplementation":[49,208],"(2.4":[50],"g/d)":[51],"on":[52],"levels":[54,112,118,158,176,184,213],"MMP-9,":[56,215],"tissue":[57],"inhibitor":[58],"metalloproteinase":[60],"(TIMP-1)":[61],"pregnancy-associated":[63],"plasma":[64],"protein":[65],"(PAPP-A)":[66],"population":[69],"elderly":[71],"men":[72],"at":[73],"high":[74],"CVD":[77],"(n":[78],"=":[79,127],"563,":[80],"age":[81],"70+/-6":[82],"years).":[83],"We":[84],"further":[85],"explored":[86],"association":[88],"these":[90],"markers":[91],"different":[93],"entities,":[95],"carotid":[96],"intima":[97],"media":[98],"thickness":[99],"(IMT)":[100],"CVD.":[106,201],"RESULTS:":[107],"Smokers":[108],"had":[109],"significantly":[110,131],"higher":[111],"MMP-9":[114,129,155,178],"(p<0.0001),":[115],"TIMP-1":[117,186,216],"were":[119,142,162],"lower":[120],"subjects":[122],"with":[123,133,137,169,189,203],"previous":[124,190],"AMI":[125,191],"(p":[126],"0.021).":[128],"was":[130],"correlated":[132],"LDL-C":[134],"inversely":[136],"HDL-C":[138],"(both":[139],"p<0.0001).":[140],"There":[141],"no":[143,170],"significant":[144],"correlations":[145],"measured":[148],"variables":[149],"IMT.":[151],"Significant":[152],"reductions":[153],"PAPP-A":[157,218],"after":[159],"36":[160],"months":[161],"found":[163],"all":[165],"study":[166],"groups,":[167],"however,":[168],"between-group":[171],"differences.":[172],"CONCLUSIONS:":[173],"elevated":[175],"smokers":[180],"reduced":[183],"patients":[188],"reflect":[192],"an":[193],"importance":[194],"development":[199],"Intervention":[202],"diet":[204],"did":[209],"not":[210],"or":[217],"present":[221],"population.":[222]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}