{"id":"https://openalex.org/W2005446354","doi":"https://doi.org/10.1258/000456306776865241","title":"A case of low cortisol-binding globulin: use of plasma free cortisol in interpretation of hypothalamic-pituitary-adrenal axis tests","display_name":"A case of low cortisol-binding globulin: use of plasma free cortisol in interpretation of hypothalamic-pituitary-adrenal axis tests","publication_year":2006,"publication_date":"2006-04-26","ids":{"openalex":"https://openalex.org/W2005446354","doi":"https://doi.org/10.1258/000456306776865241","mag":"2005446354","pmid":"https://pubmed.ncbi.nlm.nih.gov/16704764"},"language":"en","primary_location":{"id":"doi:10.1258/000456306776865241","doi":"https://doi.org/10.1258/000456306776865241","is_oa":true,"landing_page_url":"https://doi.org/10.1258/000456306776865241","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1258/000456306776865241","source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1258/000456306776865241","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051741164","display_name":"James S. Davidson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801418622","display_name":"Auckland City Hospital","ror":"https://ror.org/05e8jge82","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I2801418622","https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"James S Davidson","raw_affiliation_strings":["Department of Chemical Pathology, Labplus, Auckland City Hospital, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology, Labplus, Auckland City Hospital, Auckland, New Zealand","institution_ids":["https://openalex.org/I2801418622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068597827","display_name":"Mark J Bolland","orcid":"https://orcid.org/0000-0003-0465-2674","observed_orcids":["https://orcid.org/0000-0003-0465-2674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark J Bolland","raw_affiliation_strings":["Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111849510","display_name":"MICHAEL S. CROXSON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801418622","display_name":"Auckland City Hospital","ror":"https://ror.org/05e8jge82","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I2801418622","https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Michael S Croxson","raw_affiliation_strings":["Department of Endocrinology, Auckland Hospital, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Auckland Hospital, Auckland, New Zealand","institution_ids":["https://openalex.org/I2801418622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006256132","display_name":"Weldon Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801418622","display_name":"Auckland City Hospital","ror":"https://ror.org/05e8jge82","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I2801418622","https://openalex.org/I4405259026"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Weldon Chiu","raw_affiliation_strings":["Department of Chemical Pathology , Labplus , Auckland City Hospital , Auckland ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Pathology , Labplus , Auckland City Hospital , Auckland ;","institution_ids":["https://openalex.org/I2801418622"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006695630","display_name":"John G. Lewis","orcid":"https://orcid.org/0000-0003-2757-4111","observed_orcids":["https://orcid.org/0000-0003-2757-4111"]},"institutions":[{"id":"https://openalex.org/I4210097713","display_name":"Canterbury Health Laboratories","ror":"https://ror.org/00wspbn44","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I4210097713"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"John G Lewis","raw_affiliation_strings":["Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand","institution_ids":["https://openalex.org/I4210097713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.3574,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.82458469,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"43","issue":"3","first_page":"237","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.9210000038146973},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metyrapone-test","display_name":"metyrapone test","score":0.984000027179718},{"id":"https://openalex.org/keywords/11-deoxycortisol","display_name":"11-deoxycortisol","score":0.847000002861023},{"id":"https://openalex.org/keywords/total-cortisol","display_name":"total cortisol","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8690770864486694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8632237911224365},{"id":"https://openalex.org/C90134679","wikidata":"https://www.wikidata.org/wiki/Q416227","display_name":"Transcortin","level":3,"score":0.8400893211364746},{"id":"https://openalex.org/C2776719974","wikidata":"https://www.wikidata.org/wiki/Q821641","display_name":"Metyrapone","level":2,"score":0.7621340751647949},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.7176607847213745},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.5916029810905457},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.5135350227355957},{"id":"https://openalex.org/C62913699","wikidata":"https://www.wikidata.org/wiki/Q5173333","display_name":"Cortisol awakening response","level":3,"score":0.5098627805709839},{"id":"https://openalex.org/C2908704050","wikidata":"https://www.wikidata.org/wiki/Q560542","display_name":"Cosyntropin","level":4,"score":0.5094946026802063},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.48477715253829956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4707178473472595},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3203441798686981}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008797","descriptor_name":"Metyrapone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1258/000456306776865241","doi":"https://doi.org/10.1258/000456306776865241","is_oa":true,"landing_page_url":"https://doi.org/10.1258/000456306776865241","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1258/000456306776865241","source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:16704764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16704764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical biochemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1258/000456306776865241","doi":"https://doi.org/10.1258/000456306776865241","is_oa":true,"landing_page_url":"https://doi.org/10.1258/000456306776865241","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1258/000456306776865241","source":{"id":"https://openalex.org/S175011280","display_name":"Annals of Clinical Biochemistry International Journal of Laboratory Medicine","issn_l":"0004-5632","issn":["0004-5632","1758-1001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Biochemistry: International Journal of Laboratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005446354.pdf","grobid_xml":"https://content.openalex.org/works/W2005446354.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1997644403","https://openalex.org/W2023342988","https://openalex.org/W2032093198","https://openalex.org/W2073862919","https://openalex.org/W2108958077","https://openalex.org/W2120836186","https://openalex.org/W2125017989","https://openalex.org/W2136962727","https://openalex.org/W2158554253","https://openalex.org/W2165072455"],"related_works":["https://openalex.org/W2158554253","https://openalex.org/W7097051755","https://openalex.org/W1989206476","https://openalex.org/W2023342988","https://openalex.org/W2120836186","https://openalex.org/W2105893279","https://openalex.org/W2120896018","https://openalex.org/W2018999941","https://openalex.org/W6903926389","https://openalex.org/W1997717192"],"abstract_inverted_index":{"We":[0,77],"investigated":[1],"a":[2,56,92],"patient":[3,54,90],"with":[4,15],"suspected":[5],"hypopituitarism":[6],"who":[7],"showed":[8],"subnormal":[9,81],"cortisol":[10,48,51,66,69,83,105,108],"responses":[11,26,72,84],"to":[12,44,73,85],"stimulation":[13],"tests":[14,117],"adrenocorticotrophic":[16],"hormone":[17],"(ACTH)":[18],"and":[19,24,41,49,67,87,101],"hypoglycaemia,":[20,88],"but":[21],"normal":[22,93],"ACTH":[23,74,86],"11-deoxycortisol":[25],"in":[27,62],"the":[28,89,119],"metyrapone":[29],"test.":[30],"Cortisol-binding":[31],"globulin":[32],"(CBG)":[33],"was":[34,42],"measured":[35],"by":[36],"enzyme-linked":[37],"immunosorbent":[38],"assay":[39],"(ELISA),":[40],"used":[43],"calculate":[45],"plasma":[46,58,124],"free":[47,50,65,68,104,107],"index.":[52],"The":[53],"had":[55,91],"low":[57],"CBG":[59,99],"concentration.":[60],"Reinterpreted":[61],"terms":[63],"of":[64,98,103,115,118],"index,":[70],"his":[71],"were":[75],"normal.":[76],"conclude":[78],"that":[79],"despite":[80],"total":[82,125],"hypothalamic-pituitary-adrenal":[94],"(HPA)":[95],"axis.":[96],"Measurement":[97],"concentration":[100],"calculation":[102],"or":[106],"index":[109],"can":[110],"help":[111],"avoid":[112],"false":[113],"interpretations":[114],"dynamic":[116],"HPA":[120],"axis":[121],"based":[122],"on":[123],"cortisol.":[126]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}