{"id":"https://openalex.org/W2005411277","doi":"https://doi.org/10.1158/1538-7445.am2011-3561","title":"Abstract 3561: Pazopanib inhibits a subpopulation of PDGFR+ astrocytes in the neuro-inflammatory microenvironment of breast cancer brain metastases","display_name":"Abstract 3561: Pazopanib inhibits a subpopulation of PDGFR+ astrocytes in the neuro-inflammatory microenvironment of breast cancer brain metastases","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2005411277","doi":"https://doi.org/10.1158/1538-7445.am2011-3561","mag":"2005411277"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-3561","doi":"https://doi.org/10.1158/1538-7445.am2011-3561","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-3561","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069533295","display_name":"Brunilde Gril","orcid":"https://orcid.org/0000-0003-0405-4818","observed_orcids":["https://orcid.org/0000-0003-0405-4818"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brunilde Gril","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD","1National Cancer Inst., Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066138864","display_name":"Fernando Vidal\u2010Vanaclocha","orcid":"https://orcid.org/0000-0002-0632-1214","observed_orcids":["https://orcid.org/0000-0002-0632-1214"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando Vidal-Vanaclocha","raw_affiliation_strings":["2CEU-San Pablo University School of Medicine Urb. Montepri\u0301ncipe, Boadilla del Monte, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2CEU-San Pablo University School of Medicine Urb. Montepri\u0301ncipe, Boadilla del Monte, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046283873","display_name":"Yong Ri Qian","orcid":"https://orcid.org/0000-0001-7138-0141","observed_orcids":["https://orcid.org/0000-0001-7138-0141"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Qian","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD","1National Cancer Inst., Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063126623","display_name":"David J. Liewehr","orcid":"https://orcid.org/0000-0002-1039-7713","observed_orcids":["https://orcid.org/0000-0002-1039-7713"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Liewehr","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD","1National Cancer Inst., Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044239219","display_name":"Seth M. Steinberg","orcid":"https://orcid.org/0000-0002-8280-551X","observed_orcids":["https://orcid.org/0000-0002-8280-551X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth M. Steinberg","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD","1National Cancer Inst., Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110509","display_name":"Diane Palmieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Palmieri","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD","1National Cancer Inst., Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035391817","display_name":"Patricia Schriver Steeg","orcid":"https://orcid.org/0000-0002-2626-0594","observed_orcids":["https://orcid.org/0000-0002-2626-0594"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia S. Steeg","raw_affiliation_strings":["1National Cancer Inst., Bethesda, MD","1National Cancer Inst., Bethesda, MD;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"1National Cancer Inst., Bethesda, MD;","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"3561","last_page":"3561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pazopanib","display_name":"pazopanib","score":0.8799999952316284},{"id":"https://openalex.org/keywords/breast-cancer-brain-metastases","display_name":"breast cancer brain metastasis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.6919999718666077},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.6600000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.593999981880188},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.6420000195503235},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/brain-colonization","display_name":"brain colonization","score":0.39100000262260437},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.3880000114440918},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.964119553565979},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.7818571329116821},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6412876844406128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6129076480865479},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5564652681350708},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5503548383712769},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5121150016784668},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.4291139543056488},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3702651858329773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35020825266838074},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.18205997347831726}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-3561","doi":"https://doi.org/10.1158/1538-7445.am2011-3561","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-3561","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3208685703","https://openalex.org/W2968704303","https://openalex.org/W2356627091","https://openalex.org/W3080484223","https://openalex.org/W2150929601","https://openalex.org/W2606889348","https://openalex.org/W1509148494","https://openalex.org/W2364360566","https://openalex.org/W2096928109","https://openalex.org/W2806459696"],"abstract_inverted_index":{"Abstract":[0],"Brain":[1,202],"metastases":[2,156,164,203],"occur":[3],"in":[4,68,268],"approximately":[5],"35%":[6],"of":[7,33,38,50,64,102,109,124,135,165,182,233,238,260,277,311,323,353,358],"metastatic":[8,62],"breast":[9,23,65,166],"cancer":[10,24,66],"patients":[11],"whose":[12],"tumors":[13],"overexpress":[14],"HER2.":[15],"Using":[16],"a":[17,34,73,195,236,257,269,308],"quantitative":[18],"model":[19],"system":[20],"to":[21,47,227],"study":[22],"brain":[25,31,35,112,139,155,163,210,217,222,254,315,327,342],"metastasis,":[26],"HER2":[27,43],"overexpression":[28,49],"increased":[29],"the":[30,55,61,69,96,100,107,133,138,171,178,221,228,253,278,314,318,326,354,359],"colonization":[32],"seeking":[36],"subline":[37],"MDA-MB-231":[39],"cells":[40,67,126],"(231-BR-HER2).":[41],"Since":[42],"has":[44,118],"been":[45,119],"shown":[46],"induce":[48],"VEGF,":[51],"we":[52,131],"hypothesized":[53],"that":[54,92],"anti-angiogenic":[56],"drug":[57,337],"pazopanib":[58,93,136,193,312,324],"would":[59],"reduce":[60],"outgrowth":[63,108],"brain.":[70],"Pazopanib":[71,105,265,292],"is":[72],"multispecific":[74],"tyrosine":[75,231],"kinase":[76],"inhibitor":[77],"targeting":[78],"VEGFR-1,":[79],"-2,":[80],"and":[81,85,87,127,145,152,209,273,287],"-3,":[82],"PDGFR":[83,234,280],"alpha":[84],"beta,":[86,235],"c-kit.":[88],"We":[89],"previously":[90,243],"showed":[91],"directly":[94],"targets":[95],"tumor":[97,125,263,332],"cell":[98,173],"through":[99],"disruption":[101],"B-Raf":[103],"pathway.":[104],"prevented":[106],"231-BR-HER2":[110,172],"large":[111],"metastasis":[113,343],"by":[114,262],"73%":[115],"(p<0.0001).":[116],"Metastasis":[117],"described":[120],"as":[121,157,159,329,331],"an":[122,225,321,338],"interaction":[123],"their":[128],"environment.":[129],"Here":[130],"evaluated":[132],"effect":[134,297,310,322],"on":[137,198,298,313,325],"neuro-inflammatory":[140],"microenvironment.":[141,316],"Previously,":[142],"activated":[143,146],"microglia":[144,303],"GFAP-expression":[147],"astrocytes":[148,240,248,261],"were":[149,186,204,212,249],"observed":[150],"around":[151,252],"within":[153],"experimental":[154],"well":[158,330],"from":[160],"resected":[161],"human":[162],"cancer.":[167],"In":[168,220,290],"our":[169],"experiments,":[170],"line":[174],"was":[175,241],"injected":[176],"into":[177],"left":[179],"cardiac":[180],"ventricle":[181],"immunocompromised":[183],"mice;":[184],"mice":[185],"treated":[187],"with":[188,214],"vehicle,":[189],"30mg/kg":[190],"or":[191,302],"100mg/kg":[192,288],"twice":[194],"day":[196,199],"beginning":[197],"3":[200],"post-injection.":[201],"counted":[205],"using":[206,224],"H&E":[207],"staining":[208],"slides":[211],"immunostained":[213],"markers":[215],"for":[216,341,362],"micro-environment":[218],"components.":[219],"metastases,":[223,255],"antibody":[226],"phosphorylation":[229],"site":[230],"751":[232],"subpopulation":[237],"GFAP+":[239],"observed,":[242],"undescribed.":[244],"P-PDGFR":[245],"beta":[246,281],"+":[247,282],"only":[250],"detected":[251],"suggesting":[256],"specific":[258,309],"activation":[259],"cells.":[264],"treatment":[266],"resulted":[267],"trend,":[270],"76%":[271],"(p=0.13)":[272],"80%":[274],"(p=0.070)":[275],"decrease":[276],"pY751":[279],"astrocyte":[283],"population,":[284],"at":[285],"30":[286],"respectively.":[289],"contrast,":[291],"did":[293],"not":[294],"have":[295],"any":[296],"NG2+pericyte,":[299],"collagen":[300],"IV":[301],"expression.":[304],"The":[305],"data":[306,319],"suggest":[307],"Collectively,":[317],"identify":[320],"microenvironment,":[328],"cells,":[333],"which":[334],"makes":[335],"this":[336],"interesting":[339],"candidate":[340],"prevention.":[344],"Citation":[345],"Format:":[346],"{Authors}.":[347],"{Abstract":[348],"title}":[349],"[abstract].":[350],"In:":[351],"Proceedings":[352],"102nd":[355],"Annual":[356],"Meeting":[357],"American":[360],"Association":[361],"Cancer":[363,373],"Research;":[364],"2011":[365],"Apr":[366],"2-6;":[367],"Orlando,":[368],"FL.":[369],"Philadelphia":[370],"(PA):":[371],"AACR;":[372],"Res":[374],"2011;71(8":[375],"Suppl):Abstract":[376],"nr":[377],"3561.":[378],"doi:10.1158/1538-7445.AM2011-3561":[379]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}