{"id":"https://openalex.org/W2005408445","doi":"https://doi.org/10.1371/journal.pone.0122512","title":"Crystal Structure of a Two-Subunit TrkA Octameric Gating Ring Assembly","display_name":"Crystal Structure of a Two-Subunit TrkA Octameric Gating Ring Assembly","publication_year":2015,"publication_date":"2015-03-31","ids":{"openalex":"https://openalex.org/W2005408445","doi":"https://doi.org/10.1371/journal.pone.0122512","mag":"2005408445","pmid":"https://pubmed.ncbi.nlm.nih.gov/25826626"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0122512","doi":"https://doi.org/10.1371/journal.pone.0122512","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0122512","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122512&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122512&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072187299","display_name":"Marc C. Deller","orcid":"https://orcid.org/0000-0001-8070-6502","observed_orcids":["https://orcid.org/0000-0001-8070-6502"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc C. Deller","raw_affiliation_strings":["The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210091204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112471372","display_name":"Hope A. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hope A. Johnson","raw_affiliation_strings":["The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210091204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009606823","display_name":"Mitchell D. Miller","orcid":"https://orcid.org/0000-0003-1626-4943","observed_orcids":["https://orcid.org/0000-0003-1626-4943"]},"institutions":[{"id":"https://openalex.org/I2801935854","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell D. Miller","raw_affiliation_strings":["The Joint Center for Structural Genomics, and Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America","institution_ids":["https://openalex.org/I2801935854","https://openalex.org/I4210091204","https://openalex.org/I4210120900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016539643","display_name":"Glen Spraggon","orcid":"https://orcid.org/0000-0001-7880-8454","observed_orcids":["https://orcid.org/0000-0001-7880-8454"]},"institutions":[{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glen Spraggon","raw_affiliation_strings":["Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America","institution_ids":["https://openalex.org/I127128434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031232289","display_name":"Marc\u2010Andr\u00e9 Elsliger","orcid":"https://orcid.org/0000-0002-1989-7626","observed_orcids":["https://orcid.org/0000-0002-1989-7626"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc-Andr\u00e9 Elsliger","raw_affiliation_strings":["The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210091204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010315360","display_name":"Ian A. Wilson","orcid":"https://orcid.org/0000-0002-6469-2419","observed_orcids":["https://orcid.org/0000-0002-6469-2419"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian A. Wilson","raw_affiliation_strings":["The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210091204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067217335","display_name":"Scott A. Lesley","orcid":"https://orcid.org/0000-0002-7905-8840","observed_orcids":["https://orcid.org/0000-0002-7905-8840"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I127128434","display_name":"Genomics Institute of the Novartis Research Foundation","ror":"https://ror.org/017136v53","country_code":"US","type":"facility","lineage":["https://openalex.org/I127128434","https://openalex.org/I1283582996","https://openalex.org/I4210117619"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott A. Lesley","raw_affiliation_strings":["The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America; Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America","Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America","The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America; Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I127128434","https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America","institution_ids":["https://openalex.org/I127128434"]},{"raw_affiliation_string":"The Joint Center for Structural Genomics, and Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210091204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5067217335","https://openalex.org/A5072187299"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I127128434","https://openalex.org/I4210091204"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.04607665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"3","first_page":"e0122512","last_page":"e0122512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.9110000133514404},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.5230000019073486},{"id":"https://openalex.org/keywords/gating-ring","display_name":"gating ring","score":0.7990000247955322},{"id":"https://openalex.org/keywords/potassium-transporters","display_name":"potassium transporters","score":0.5400000214576721},{"id":"https://openalex.org/keywords/quaternary-structure","display_name":"quaternary structure","score":0.8830000162124634},{"id":"https://openalex.org/keywords/structural-homology","display_name":"structural homology","score":0.6990000009536743},{"id":"https://openalex.org/keywords/ion-channel-evolution","display_name":"ion channel evolution","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.7977489233016968},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6481338739395142},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4601486325263977},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4546710252761841},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4524964690208435},{"id":"https://openalex.org/C134139212","wikidata":"https://www.wikidata.org/wiki/Q24719927","display_name":"Trk receptor","level":4,"score":0.42464590072631836},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.4147467613220215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40868234634399414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38212186098098755},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35972076654434204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29674577713012695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10869428515434265},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0122512","doi":"https://doi.org/10.1371/journal.pone.0122512","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0122512","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122512&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:25826626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25826626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1211628","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1211628","pdf_url":"https://www.osti.gov/servlets/purl/1211628","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:europepmc.org:3355825","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4380455","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4380455","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4380455","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:786a0a1d07d640b7a732a35ec3596383","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/786a0a1d07d640b7a732a35ec3596383","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 3, p e0122512 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0122512","doi":"https://doi.org/10.1371/journal.pone.0122512","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0122512","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122512&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1398330795","display_name":null,"funder_award_id":"DE-AC03-?","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1614572836","display_name":null,"funder_award_id":"DE AC03 76SF00098","funder_id":"https://openalex.org/F4320338292","funder_display_name":"Lawrence Berkeley National Laboratory"},{"id":"https://openalex.org/G1643223109","display_name":null,"funder_award_id":"AC03-76SF00098","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G193590374","display_name":null,"funder_award_id":"DEAC03-76SF00098","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1984473900","display_name":null,"funder_award_id":"U54GM094586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2787076192","display_name":null,"funder_award_id":"DEAC03-76SF00098","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G301008592","display_name":null,"funder_award_id":"DE-AC03-76SF-00098","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G3444594369","display_name":null,"funder_award_id":"AC03-76SF00098","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G4047395780","display_name":null,"funder_award_id":"GM094586","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7444770027","display_name":null,"funder_award_id":"DE-AC03- 76SF00098","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000140088","display_name":null,"funder_award_id":"U54\u2010GM094586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000331358","display_name":null,"funder_award_id":"GM094586","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338292","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005408445.pdf","grobid_xml":"https://content.openalex.org/works/W2005408445.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W25097415","https://openalex.org/W1539796472","https://openalex.org/W1574972316","https://openalex.org/W1584653951","https://openalex.org/W1669459870","https://openalex.org/W1756233575","https://openalex.org/W1831325397","https://openalex.org/W1876441925","https://openalex.org/W1972946273","https://openalex.org/W1980385831","https://openalex.org/W1985842673","https://openalex.org/W1990107107","https://openalex.org/W1994286350","https://openalex.org/W1996002552","https://openalex.org/W1998322821","https://openalex.org/W2000499608","https://openalex.org/W2001641653","https://openalex.org/W2004559437","https://openalex.org/W2004798546","https://openalex.org/W2013083986","https://openalex.org/W2016765195","https://openalex.org/W2030417955","https://openalex.org/W2034297767","https://openalex.org/W2036883652","https://openalex.org/W2036902401","https://openalex.org/W2038840577","https://openalex.org/W2039181331","https://openalex.org/W2040351161","https://openalex.org/W2050839170","https://openalex.org/W2058646563","https://openalex.org/W2077776336","https://openalex.org/W2078731516","https://openalex.org/W2082362903","https://openalex.org/W2082846873","https://openalex.org/W2086503730","https://openalex.org/W2088986479","https://openalex.org/W2094504398","https://openalex.org/W2098436218","https://openalex.org/W2100837269","https://openalex.org/W2101204196","https://openalex.org/W2105013618","https://openalex.org/W2106207499","https://openalex.org/W2109184569","https://openalex.org/W2114030624","https://openalex.org/W2117239890","https://openalex.org/W2118058448","https://openalex.org/W2120961946","https://openalex.org/W2122339645","https://openalex.org/W2126007769","https://openalex.org/W2135737750","https://openalex.org/W2137421512","https://openalex.org/W2140094919","https://openalex.org/W2143739555","https://openalex.org/W2144081223","https://openalex.org/W2147526198","https://openalex.org/W2152966133","https://openalex.org/W2153269862","https://openalex.org/W2158266834","https://openalex.org/W2162244749","https://openalex.org/W2162970494","https://openalex.org/W2170623915","https://openalex.org/W2180229411","https://openalex.org/W2943793810","https://openalex.org/W3196492948","https://openalex.org/W4240895940","https://openalex.org/W7020123318"],"related_works":["https://openalex.org/W2054436155","https://openalex.org/W2163763677","https://openalex.org/W2006225931","https://openalex.org/W3174719410","https://openalex.org/W2140366271","https://openalex.org/W2144198186","https://openalex.org/W2021104084","https://openalex.org/W3094005698","https://openalex.org/W2764274701","https://openalex.org/W2012257489"],"abstract_inverted_index":{"The":[0,41,66],"TM1088":[1,67,102,121],"locus":[2],"of":[3,21,32,38,46,49,96,107,119,154],"T.":[4],"maritima":[5],"codes":[6],"for":[7],"two":[8],"proteins":[9,68,85],"designated":[10],"TM1088A":[11,52],"and":[12,53,62,75,116,128],"TM1088B,":[13,54],"which":[14],"combine":[15],"to":[16,35,59,72,76],"form":[17,86],"the":[18,29,47,50,94,100,104,113,120,143],"cytosolic":[19,88],"portion":[20],"a":[22,36,87,108],"putative":[23],"Trk":[24,110],"K+":[25,78,97,136,158],"transporter.":[26],"We":[27],"report":[28],"crystal":[30,44],"structure":[31,106,141],"this":[33],"assembly":[34,91],"resolution":[37,43],"3.45":[39],"\u00c5.":[40],"high":[42],"structures":[45],"components":[48],"assembly,":[51,122],"were":[55],"also":[56],"determined":[57],"independently":[58],"1.50":[60],"\u00c5":[61],"1.55":[63],"\u00c5,":[64],"respectively.":[65],"are":[69],"structurally":[70],"homologous":[71],"each":[73],"other":[74,77,134],"transporter":[79],"proteins,":[80],"such":[81],"as":[82],"TrkA.":[83],"These":[84],"gating":[89,137,159],"ring":[90,138,160],"that":[92],"controls":[93],"flow":[95],"ions":[98],"across":[99],"membrane.":[101],"represents":[103],"first":[105,144],"two-subunit":[109],"assembly.":[111],"Despite":[112],"atypical":[114],"genetics":[115],"chain":[117],"organization":[118,132],"it":[123],"shares":[124],"significant":[125],"structural":[126,145],"homology":[127],"an":[129,151],"overall":[130],"quaternary":[131],"with":[133],"single-subunit":[135,157],"assemblies.":[139,161],"This":[140],"provides":[142],"insights":[146],"into":[147],"what":[148],"may":[149],"be":[150],"evolutionary":[152],"ancestor":[153],"more":[155],"modern":[156]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
