{"id":"https://openalex.org/W2005406090","doi":"https://doi.org/10.1074/jbc.m808788200","title":"Induction of MicroRNA-221 by Platelet-derived Growth Factor Signaling Is Critical for Modulation of Vascular Smooth Muscle Phenotype","display_name":"Induction of MicroRNA-221 by Platelet-derived Growth Factor Signaling Is Critical for Modulation of Vascular Smooth Muscle Phenotype","publication_year":2008,"publication_date":"2008-12-17","ids":{"openalex":"https://openalex.org/W2005406090","doi":"https://doi.org/10.1074/jbc.m808788200","mag":"2005406090","pmid":"https://pubmed.ncbi.nlm.nih.gov/19088079","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2635044"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m808788200","doi":"https://doi.org/10.1074/jbc.m808788200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m808788200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m808788200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076934479","display_name":"Brandi N. Davis\u2010Dusenbery","orcid":"https://orcid.org/0000-0001-7811-8613","observed_orcids":["https://orcid.org/0000-0001-7811-8613"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi N. Davis","raw_affiliation_strings":["Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, USA","Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111","Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042609664","display_name":"Aaron C. Hilyard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron C. Hilyard","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter H. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H. Nguyen","raw_affiliation_strings":["Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111","Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088569489","display_name":"Giorgio Lagna","orcid":"https://orcid.org/0000-0001-9228-4554","observed_orcids":["https://orcid.org/0000-0001-9228-4554"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giorgio Lagna","raw_affiliation_strings":["Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084560496","display_name":"Akiko Hata","orcid":"https://orcid.org/0000-0003-3784-1738","observed_orcids":["https://orcid.org/0000-0003-3784-1738"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Akiko Hata","raw_affiliation_strings":["Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111","Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084560496"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.5533,"has_fulltext":false,"cited_by_count":330,"citation_normalized_percentile":{"value":0.97567624,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"284","issue":"6","first_page":"3728","last_page":"3738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-221","display_name":"miR-221","score":0.9940000176429749},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-signaling","display_name":"platelet-derived growth factor signaling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/smooth-muscle-cell-phenotype","display_name":"smooth muscle cell phenotype","score":0.6190000176429749},{"id":"https://openalex.org/keywords/c-kit","display_name":"CD117","score":0.8289999961853027},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/myocardin","display_name":"myocardin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2780286377","wikidata":"https://www.wikidata.org/wiki/Q18048730","display_name":"Myocardin","level":5,"score":0.8302342891693115},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.7579224705696106},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.7041667103767395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.703046977519989},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.694344162940979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6338806748390198},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.602139949798584},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5645690560340881},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5422947406768799},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5202509164810181},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5006914138793945},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49758079648017883},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44648128747940063},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.43988317251205444},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4297885596752167},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.2754668593406677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24643060564994812},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18907952308654785},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12622517347335815},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12340140342712402},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.058284759521484375}],"mesh":[{"descriptor_ui":"D000099251","descriptor_name":"Myocardin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m808788200","doi":"https://doi.org/10.1074/jbc.m808788200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m808788200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:19088079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19088079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2635044","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2635044/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:scholarcommons.scu.edu:bio-1117","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.scu.edu/bio/118","pdf_url":null,"source":{"id":"https://openalex.org/S4377196452","display_name":"Scholar Commons (Santa Clara University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16269868","host_organization_name":"Santa Clara University","host_organization_lineage":["https://openalex.org/I16269868"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m808788200","doi":"https://doi.org/10.1074/jbc.m808788200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m808788200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2300500447","display_name":"Role of miRNAs in Vascular Physiology","funder_award_id":"R01HL093154","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G669424249","display_name":"Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension","funder_award_id":"R01HL082854","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7668207751","display_name":"Role of BMP Signaling in Vascular Wall Homeostasis","funder_award_id":"R21HL086572","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1608268501","https://openalex.org/W1912592877","https://openalex.org/W1967738006","https://openalex.org/W1972989638","https://openalex.org/W1973403102","https://openalex.org/W1978274374","https://openalex.org/W1985402095","https://openalex.org/W1986706724","https://openalex.org/W1988163167","https://openalex.org/W2001444915","https://openalex.org/W2001574179","https://openalex.org/W2002995168","https://openalex.org/W2013920531","https://openalex.org/W2015018301","https://openalex.org/W2019813054","https://openalex.org/W2026004604","https://openalex.org/W2027097496","https://openalex.org/W2030497421","https://openalex.org/W2030607381","https://openalex.org/W2036199559","https://openalex.org/W2041825143","https://openalex.org/W2042742026","https://openalex.org/W2047362768","https://openalex.org/W2051307565","https://openalex.org/W2055992003","https://openalex.org/W2057265838","https://openalex.org/W2065566217","https://openalex.org/W2078224929","https://openalex.org/W2079472722","https://openalex.org/W2081119041","https://openalex.org/W2081134904","https://openalex.org/W2084400739","https://openalex.org/W2087206434","https://openalex.org/W2087661971","https://openalex.org/W2088702241","https://openalex.org/W2096433394","https://openalex.org/W2104567339","https://openalex.org/W2106638787","https://openalex.org/W2109221701","https://openalex.org/W2110043783","https://openalex.org/W2110743056","https://openalex.org/W2113175417","https://openalex.org/W2113209482","https://openalex.org/W2113727732","https://openalex.org/W2114403176","https://openalex.org/W2119479407","https://openalex.org/W2121822802","https://openalex.org/W2127851311","https://openalex.org/W2128674168","https://openalex.org/W2131596261","https://openalex.org/W2133220812","https://openalex.org/W2139274621","https://openalex.org/W2141655062","https://openalex.org/W2144753743","https://openalex.org/W2147944062","https://openalex.org/W2149385948","https://openalex.org/W2150581509","https://openalex.org/W2152673117","https://openalex.org/W2155214429","https://openalex.org/W2157754963","https://openalex.org/W2163196046","https://openalex.org/W2163280886","https://openalex.org/W2165801731","https://openalex.org/W2167566197","https://openalex.org/W2168241534","https://openalex.org/W2171362256","https://openalex.org/W2597632520","https://openalex.org/W4251765607"],"related_works":["https://openalex.org/W2055810659","https://openalex.org/W2131736566","https://openalex.org/W2765685634","https://openalex.org/W2042259396","https://openalex.org/W2615938559","https://openalex.org/W2232957213","https://openalex.org/W928816491","https://openalex.org/W2417443534","https://openalex.org/W2551953540","https://openalex.org/W2010202107"],"abstract_inverted_index":{"The":[0,58],"platelet-derived":[1],"growth":[2],"factor":[3],"(PDGF)":[4],"signaling":[5],"pathway":[6,20],"is":[7,100,123],"a":[8,31,40,78,83,148],"critical":[9,124,167],"regulator":[10],"of":[11,17,33,54,65,85,89,112,119,128,136,145,163,169],"animal":[12],"development":[13],"and":[14,50,56,116,178],"homeostasis.":[15],"Activation":[16],"the":[18,46,52,75,86,113,143,161,170],"PDGF":[19,94,104,157],"leads":[21],"to":[22,26,39,93,110],"neointimal":[23],"proliferative":[24],"responses":[25],"artery":[27],"injury;":[28],"it":[29],"promotes":[30],"switch":[32],"vascular":[34],"smooth":[35],"muscle":[36],"cells":[37],"(vSMC)":[38],"less":[41],"contractile":[42,138],"phenotype":[43],"by":[44,121,141,159],"inhibiting":[45],"SMC-specific":[47,137,150],"gene":[48,139,176],"expression":[49,144,162,177],"increasing":[51],"rate":[53],"proliferation":[55],"migration.":[57],"molecular":[59],"mechanism":[60],"for":[61,125],"these":[62],"pleiotropic":[63],"effects":[64],"PDGFs":[66],"has":[67],"not":[68],"been":[69],"fully":[70],"described.":[71],"Here,":[72],"we":[73],"identify":[74],"microRNA-221":[76],"(miR-221),":[77],"small":[79],"noncoding":[80],"RNA,":[81],"as":[82],"modulator":[84],"phenotypic":[87],"change":[88],"vSMCs":[90],"in":[91,106],"response":[92],"signaling.":[95],"We":[96],"demonstrate":[97],"that":[98,156],"miR-221":[99,122],"transcriptionally":[101],"induced":[102],"upon":[103],"treatment":[105],"primary":[107],"vSMCs,":[108],"leading":[109],"down-regulation":[111],"targets":[114],"c-Kit":[115,133],"p27Kip1.":[117],"Down-regulation":[118],"p27Kip1":[120],"PDGF-mediated":[126],"induction":[127],"cell":[129,179],"proliferation.":[130,180],"Additionally,":[131],"decreased":[132],"causes":[134],"inhibition":[135],"transcription":[140],"reducing":[142],"Myocardin":[146],"(Myocd),":[147],"potent":[149],"nuclear":[151],"coactivator.":[152],"Our":[153],"study":[154],"demonstrates":[155],"signaling,":[158],"modulating":[160],"miR-221,":[164],"regulates":[165],"two":[166],"determinants":[168],"vSMC":[171],"phenotype;":[172],"they":[173],"are":[174],"SMC":[175]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":37},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
