{"id":"https://openalex.org/W2005403990","doi":"https://doi.org/10.1111/j.1365-2249.2005.02757.x","title":"Pneumolysin-mediated activation of NF\u03baB in human neutrophils is antagonized by docosahexaenoic acid","display_name":"Pneumolysin-mediated activation of NF\u03baB in human neutrophils is antagonized by docosahexaenoic acid","publication_year":2005,"publication_date":"2005-03-30","ids":{"openalex":"https://openalex.org/W2005403990","doi":"https://doi.org/10.1111/j.1365-2249.2005.02757.x","mag":"2005403990","pmid":"https://pubmed.ncbi.nlm.nih.gov/15807851","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809376"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.2005.02757.x","doi":"https://doi.org/10.1111/j.1365-2249.2005.02757.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2005.02757.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072581162","display_name":"Heidi Fickl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"H Fickl","raw_affiliation_strings":["Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016993628","display_name":"Riana Cockeran","orcid":"https://orcid.org/0000-0001-9227-6124","observed_orcids":["https://orcid.org/0000-0001-9227-6124"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"R Cockeran","raw_affiliation_strings":["Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023582751","display_name":"Helen C. Steel","orcid":"https://orcid.org/0000-0001-5899-4472","observed_orcids":["https://orcid.org/0000-0001-5899-4472"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"H C Steel","raw_affiliation_strings":["Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056953136","display_name":"Charles H. Feldman","orcid":"https://orcid.org/0000-0002-6881-8314","observed_orcids":["https://orcid.org/0000-0002-6881-8314","https://orcid.org/0000-0002-9334-4456"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]},{"id":"https://openalex.org/I2799742747","display_name":"Johannesburg Hospital","ror":"https://ror.org/047x96110","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I2799742747"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"C Feldman","raw_affiliation_strings":["Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa","Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa","institution_ids":["https://openalex.org/I192619145","https://openalex.org/I2799742747"]},{"raw_affiliation_string":"Division of Pulmonology, Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa and","institution_ids":["https://openalex.org/I192619145","https://openalex.org/I2799742747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018065037","display_name":"Graeme J. M. Cowan","orcid":"https://orcid.org/0000-0002-1949-4253","observed_orcids":["https://orcid.org/0000-0002-1949-4253"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Cowan","raw_affiliation_strings":["Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057937276","display_name":"Timothy J. Mitchell","orcid":"https://orcid.org/0000-0002-8309-5556","observed_orcids":["https://orcid.org/0000-0002-8309-5556"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T J Mitchell","raw_affiliation_strings":["Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030988903","display_name":"Ronald Anderson","orcid":"https://orcid.org/0000-0002-5925-6452","observed_orcids":["https://orcid.org/0000-0002-5925-6452"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"R Anderson","raw_affiliation_strings":["Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria","institution_ids":["https://openalex.org/I69552723"]},{"raw_affiliation_string":"Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, University of Pretoria, Pretoria and","institution_ids":["https://openalex.org/I69552723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030988903"],"corresponding_institution_ids":["https://openalex.org/I69552723"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":1.2732,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.81081874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"140","issue":"2","first_page":"274","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pneumolysin","display_name":"pneumolysin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9179999828338623},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/omega-3-polyunsaturated-fatty-acids","display_name":"omega-3 polyunsaturated fatty acids","score":0.8939999938011169},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8769999742507935},{"id":"https://openalex.org/keywords/extracellular-calcium-influx","display_name":"extracellular calcium influx","score":0.9539999961853027},{"id":"https://openalex.org/keywords/calcium-chelation","display_name":"calcium chelation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/egta","display_name":"EGTA","score":0.9309999942779541},{"id":"https://openalex.org/keywords/staphylococcus-pneumoniae","display_name":"Staphylococcus pneumoniae","score":0.796999990940094},{"id":"https://openalex.org/keywords/proinflammatory-signaling","display_name":"pro-inflammatory signaling","score":0.6769999861717224},{"id":"https://openalex.org/keywords/anti-inflammatory-fatty-acids","display_name":"anti-inflammatory fatty acids","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776088486","wikidata":"https://www.wikidata.org/wiki/Q7205996","display_name":"Pneumolysin","level":4,"score":0.9121806621551514},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.8505144715309143},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5605441927909851},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.4682779312133789},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45489755272865295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41817545890808105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38334280252456665},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.2966025173664093},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.27719393372535706},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.11764702200889587},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013301","descriptor_name":"Streptolysins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013301","descriptor_name":"Streptolysins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013301","descriptor_name":"Streptolysins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018375","descriptor_name":"Neutrophil Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1365-2249.2005.02757.x","doi":"https://doi.org/10.1111/j.1365-2249.2005.02757.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2005.02757.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1809376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:15807851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15807851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5998e0f5-24b7-4c97-97f1-9b4559be15f2","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/5998e0f5-24b7-4c97-97f1-9b4559be15f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fickl, H, Cockeran, R, Steel, H C, Feldman, C, Cowan, G, Mitchell, T J & Anderson, R 2005, 'Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid', Clinical & Experimental Immunology, vol. 140, no. 2, pp. 274-81. https://doi.org/10.1111/j.1365-2249.2005.02757.x","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1809376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809376","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1585390661","https://openalex.org/W1605242131","https://openalex.org/W1863042354","https://openalex.org/W1954377392","https://openalex.org/W1984160742","https://openalex.org/W1985584524","https://openalex.org/W1991880580","https://openalex.org/W1994622879","https://openalex.org/W1995528870","https://openalex.org/W1997607842","https://openalex.org/W2001338358","https://openalex.org/W2003405170","https://openalex.org/W2014923210","https://openalex.org/W2031234916","https://openalex.org/W2036145275","https://openalex.org/W2038701927","https://openalex.org/W2047740928","https://openalex.org/W2052111435","https://openalex.org/W2052829627","https://openalex.org/W2063791547","https://openalex.org/W2065968830","https://openalex.org/W2066547108","https://openalex.org/W2069353151","https://openalex.org/W2072569792","https://openalex.org/W2074904804","https://openalex.org/W2080422997","https://openalex.org/W2087453197","https://openalex.org/W2088729275","https://openalex.org/W2103164703","https://openalex.org/W2106712361","https://openalex.org/W2110059042","https://openalex.org/W2110310164","https://openalex.org/W2110856309","https://openalex.org/W2122388306","https://openalex.org/W2125555008","https://openalex.org/W2126806724","https://openalex.org/W2129057300","https://openalex.org/W2137536958","https://openalex.org/W2138677630","https://openalex.org/W2148345765","https://openalex.org/W2148433370","https://openalex.org/W2149122802","https://openalex.org/W2154233793","https://openalex.org/W2159323999","https://openalex.org/W2172154969","https://openalex.org/W2291338521","https://openalex.org/W2336568046","https://openalex.org/W2418676205","https://openalex.org/W4233808990","https://openalex.org/W4249759827"],"related_works":["https://openalex.org/W2103164703","https://openalex.org/W7100194350","https://openalex.org/W2106712361","https://openalex.org/W1636178660","https://openalex.org/W7097061675","https://openalex.org/W2161204829","https://openalex.org/W1533653587","https://openalex.org/W2522445385","https://openalex.org/W1970601245","https://openalex.org/W1995528870"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,93],"designed":[3],"to":[4,26,51,91,157,186],"investigate":[5],"the":[6,34,41,44,114,122,131,160,164,168,202],"relationship":[7],"between":[8],"influx":[9,70,96,192],"of":[10,14,18,23,33,43,58,71,76,89,97,100,104,107,113,130,143,150,159,167,176,180,184,193,201],"extracellular":[11,72],"Ca(2+),":[12,98],"activation":[13,99,175],"NFkappaB":[15,59,177],"and":[16,30,56,74,83,102,137,162,178,195],"synthesis":[17,75,103,179],"interleukin-8":[19],"(IL-8)":[20],"following":[21,182],"exposure":[22,183],"human":[24],"neutrophils":[25,90,153,185],"subcytolytic":[27],"concentrations":[28],"(8.37":[29],"41.75":[31],"ng/ml)":[32],"pneumococcal":[35],"toxin,":[36,161],"pneumolysin,":[37],"as":[38,40,125,127],"well":[39,126],"potential":[42],"omega-3":[45],"polyunsaturated":[46],"fatty":[47,169],"acid,":[48,50],"docosahexaenoic":[49,134,144,207],"antagonize":[52],"these":[53,147,197],"events.":[54],"Activation":[55],"translocation":[57],"were":[60,78,109,154],"measured":[61],"using":[62,80],"a":[63,81],"radiometric":[64],"electrophoretic":[65],"mobility":[66],"shift":[67],"assay,":[68],"while":[69],"Ca(2+)":[73,194],"IL-8":[77],"determined":[79],"radioassay":[82],"an":[84],"ELISA":[85],"procedure,":[86],"respectively.":[87],"Exposure":[88],"pneumolysin":[92,151,187],"accompanied":[94],"by":[95,111,128,206],"NFkappaB,":[101],"IL-8,":[105,181],"all":[106],"which":[108],"eliminated":[110],"inclusion":[112],"Ca(2+)-chelating":[115],"agent,":[116],"EGTA":[117],"(10":[118],"m":[119],"m),":[120],"in":[121],"cell-suspending":[123],"medium,":[124],"pretreatment":[129],"cells":[132],"with":[133,152],"acid":[135,145],"(5":[136],"10":[138],"microg/ml).":[139],"The":[140],"antagonistic":[141],"effects":[142],"on":[146,190],"pro-inflammatory":[148],"interactions":[149],"not":[155],"attributable":[156],"inactivation":[158],"required":[163],"continuous":[165],"presence":[166],"acid.":[170,208],"These":[171],"observations":[172],"demonstrate":[173],"that":[174,196],"are":[188,204],"dependent":[189],"toxin-mediated":[191],"potentially":[198],"harmful":[199],"activities":[200],"toxin":[203],"antagonized":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
