{"id":"https://openalex.org/W2005403770","doi":"https://doi.org/10.1111/j.1600-0781.1996.tb00188.x","title":"Enzyme therapy of xeroderma pigmentosum: safety and efficacy testing of T4N5 liposome lotion containing a prokaryotic DNA repair enzyme","display_name":"Enzyme therapy of xeroderma pigmentosum: safety and efficacy testing of T4N5 liposome lotion containing a prokaryotic DNA repair enzyme","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2005403770","doi":"https://doi.org/10.1111/j.1600-0781.1996.tb00188.x","mag":"2005403770","pmid":"https://pubmed.ncbi.nlm.nih.gov/8956362"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0781.1996.tb00188.x","doi":"https://doi.org/10.1111/j.1600-0781.1996.tb00188.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0781.1996.tb00188.x","pdf_url":null,"source":{"id":"https://openalex.org/S197087632","display_name":"Photodermatology Photoimmunology & Photomedicine","issn_l":"0905-4383","issn":["0905-4383","1600-0781"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodermatology, Photoimmunology & Photomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015232791","display_name":"Daniel B. Yarosh","orcid":"https://orcid.org/0000-0002-0786-5985","observed_orcids":["https://orcid.org/0000-0002-0786-5985"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D. Yarosh","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York 11520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York 11520, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Klein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Klein","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031516740","display_name":"Jeannie Tsimis Kibitel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Kibitel","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003993408","display_name":"Lori Alas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Alas","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079121651","display_name":"Adrienne O\u2019Connor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. O'Connor","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"B. Cummings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Cummings","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Grab","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Grab","raw_affiliation_strings":["Applied Genetics Inc., Freeport, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Genetics Inc., Freeport, New York, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110286691","display_name":"Deborah A. Gerstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Gerstein","raw_affiliation_strings":["Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032356095","display_name":"Barbara A. Gilchrest","orcid":"https://orcid.org/0000-0001-9906-1898","observed_orcids":["https://orcid.org/0000-0001-9906-1898"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. A. Gilchrest","raw_affiliation_strings":["Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003053398","display_name":"Masamitsu Ichihashi","orcid":"https://orcid.org/0000-0002-5656-2737","observed_orcids":["https://orcid.org/0000-0002-5656-2737"]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ichihashi","raw_affiliation_strings":["Department of Dermatology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081464236","display_name":"Machiko Ogoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ogoshi","raw_affiliation_strings":["Department of Dermatology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089895","display_name":"Kobe University Hospital","ror":"https://ror.org/00bb55562","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089895"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ueda","raw_affiliation_strings":["Department of Dermatology, Kobe University School of Medicine, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kobe University School of Medicine, Kobe, Japan","institution_ids":["https://openalex.org/I4210089895","https://openalex.org/I65837984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V. Fernandez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Fernandez","raw_affiliation_strings":["Calle 84, Carretera Union Edificio Monaco, Maracaibo, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Calle 84, Carretera Union Edificio Monaco, Maracaibo, Venezuela","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110505967","display_name":"C. A. Chadwick","orcid":"https://orcid.org/0000-0001-5861-3254","observed_orcids":["https://orcid.org/0000-0001-5861-3254"]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Chadwick","raw_affiliation_strings":["CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709939","display_name":"Christopher S. Potten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129527","display_name":"Cancer Research UK Manchester Institute","ror":"https://ror.org/037405c78","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I28407311","https://openalex.org/I4210129527"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. S. Potten","raw_affiliation_strings":["CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK","institution_ids":["https://openalex.org/I4210129527","https://openalex.org/I4210131968","https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043382789","display_name":"Charlotte M. Proby","orcid":"https://orcid.org/0000-0002-3292-4836","observed_orcids":["https://orcid.org/0000-0002-3292-4836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. M. Proby","raw_affiliation_strings":["Department of Photobiology, St. John's Institute of Dermatology, Guy's and St. Thomas' Medical and Dental School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Photobiology, St. John's Institute of Dermatology, Guy's and St. Thomas' Medical and Dental School, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064410212","display_name":"Antony Richard Young","orcid":"https://orcid.org/0000-0002-4163-6772","observed_orcids":["https://orcid.org/0000-0002-4163-6772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. R. Young","raw_affiliation_strings":["Department of Photobiology, St. John's Institute of Dermatology, Guy's and St. Thomas' Medical and Dental School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Photobiology, St. John's Institute of Dermatology, Guy's and St. Thomas' Medical and Dental School, London, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108418601","display_name":"John L.M. Hawk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. M. Hawk","raw_affiliation_strings":["Department of Photobiology, St. John's Institute of Dermatology, Guy's and St. Thomas' Medical and Dental School, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Photobiology, St. John's Institute of Dermatology, Guy's and St. Thomas' Medical and Dental School, London, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015232791"],"corresponding_institution_ids":[],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.8442,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.69453174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"3","first_page":"122","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xeroderma-pigmentosum","display_name":"xeroderma pigmentosum","score":0.9959999918937683},{"id":"https://openalex.org/keywords/enzyme-therapy","display_name":"enzyme therapy","score":0.753000020980835},{"id":"https://openalex.org/keywords/dna-repair-enzymes","display_name":"DNA repair enzymes","score":0.656000018119812},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.8379999995231628},{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cyclobutane-pyrimidine-dimers","display_name":"cyclobutane pyrimidine dimers","score":0.9319999814033508},{"id":"https://openalex.org/keywords/erythema","display_name":"erythema","score":0.8870000243186951},{"id":"https://openalex.org/keywords/safety-testing","display_name":"safety testing","score":0.6029999852180481},{"id":"https://openalex.org/keywords/efficacy-evaluation","display_name":"efficacy evaluation","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2778378917","wikidata":"https://www.wikidata.org/wiki/Q612693","display_name":"Xeroderma pigmentosum","level":4,"score":0.9844726920127869},{"id":"https://openalex.org/C2780986958","wikidata":"https://www.wikidata.org/wiki/Q1871151","display_name":"Lotion","level":2,"score":0.6955386400222778},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5950769186019897},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5930825471878052},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5662146210670471},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.534720242023468},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5004575252532959},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.4502708613872528},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4408973157405853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4022914469242096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3826256990432739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3544656038284302},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3399235010147095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28612619638442993},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20739683508872986}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009824","descriptor_name":"Ointments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014983","descriptor_name":"Xeroderma Pigmentosum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043224","descriptor_name":"Deoxyribonuclease (Pyrimidine Dimer)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0781.1996.tb00188.x","doi":"https://doi.org/10.1111/j.1600-0781.1996.tb00188.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0781.1996.tb00188.x","pdf_url":null,"source":{"id":"https://openalex.org/S197087632","display_name":"Photodermatology Photoimmunology & Photomedicine","issn_l":"0905-4383","issn":["0905-4383","1600-0781"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodermatology, Photoimmunology & Photomedicine","raw_type":"journal-article"},{"id":"pmid:8956362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8956362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photodermatology, photoimmunology & photomedicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1485000848","https://openalex.org/W1494022099","https://openalex.org/W1527620733","https://openalex.org/W1554845001","https://openalex.org/W1964060678","https://openalex.org/W1971650423","https://openalex.org/W1974707302","https://openalex.org/W1987995778","https://openalex.org/W1989317177","https://openalex.org/W1998267570","https://openalex.org/W1999405881","https://openalex.org/W2002944875","https://openalex.org/W2004249150","https://openalex.org/W2005344674","https://openalex.org/W2006252149","https://openalex.org/W2006607222","https://openalex.org/W2006886434","https://openalex.org/W2007765037","https://openalex.org/W2025509081","https://openalex.org/W2029206255","https://openalex.org/W2049601212","https://openalex.org/W2065342114","https://openalex.org/W2069478795","https://openalex.org/W2081906096","https://openalex.org/W2084810313","https://openalex.org/W2085701184","https://openalex.org/W2093390384","https://openalex.org/W2122788018","https://openalex.org/W2123729564","https://openalex.org/W2134213504"],"related_works":["https://openalex.org/W7068167189","https://openalex.org/W2248118438","https://openalex.org/W2124110334","https://openalex.org/W1972542714","https://openalex.org/W2441259308","https://openalex.org/W2886024748","https://openalex.org/W2098372951","https://openalex.org/W3209255693","https://openalex.org/W1579896411","https://openalex.org/W4247646004"],"abstract_inverted_index":{"Xeroderma":[0],"pigmentosum":[1],"(XP)":[2],"is":[3],"a":[4,36],"rare":[5],"genetic":[6],"disease":[7],"in":[8,13,31,34,67,79,83,101],"which":[9,35],"patients":[10,90],"are":[11,17],"defective":[12],"DNA":[14,38,44,94,102],"repair":[15,39,95],"and":[16,63,70,103],"extremely":[18],"sensitive":[19],"to":[20,57],"solar":[21],"UV":[22],"radiation":[23],"exposure.":[24],"A":[25],"new":[26,119],"treatment":[27],"approach":[28],"was":[29,46],"tested":[30],"these":[32],"patients,":[33],"prokaryotic":[37],"enzyme":[40,120],"specific":[41],"for":[42],"UV-induced":[43],"damage":[45],"delivered":[47],"into":[48],"the":[49,59,93],"skin":[50,84,87],"by":[51],"means":[52],"of":[53,88,117],"topically":[54],"applied":[55],"liposomes":[56,96],"supplement":[58],"deficient":[60],"activity.":[61],"Acute":[62],"chronic":[64],"safety":[65],"testing":[66,116],"both":[68],"mice":[69],"humans":[71],"showed":[72,104],"neither":[73],"adverse":[74],"reactions":[75],"nor":[76],"significant":[77],"changes":[78],"serum":[80],"chemistry":[81],"or":[82],"histology.":[85],"The":[86,111],"XP":[89],"treated":[91],"with":[92],"had":[97],"fewer":[98],"cyclobutylpyrimidine":[99],"dimers":[100],"less":[105],"erythema":[106],"than":[107],"did":[108],"control":[109],"sites.":[110],"results":[112],"encourage":[113],"further":[114],"clinical":[115],"this":[118],"therapy":[121],"approach.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}