{"id":"https://openalex.org/W2005398956","doi":"https://doi.org/10.1074/jbc.r300020200","title":"Gene-altered Mice and Metabolic Flux Control","display_name":"Gene-altered Mice and Metabolic Flux Control","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2005398956","doi":"https://doi.org/10.1074/jbc.r300020200","mag":"2005398956","pmid":"https://pubmed.ncbi.nlm.nih.gov/12788933"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.r300020200","doi":"https://doi.org/10.1074/jbc.r300020200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r300020200","pdf_url":"http://www.jbc.org/article/S0021925820837971/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820837971/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018530141","display_name":"Mark A. Magnuson","orcid":"https://orcid.org/0000-0002-8824-6499","observed_orcids":["https://orcid.org/0000-0002-8824-6499"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark A. Magnuson","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, USA. mark.magnuson@vanderbilt.edu","Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, USA. mark.magnuson@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112819932","display_name":"Pengxiang She","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengxiang She","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205","Department of Molecular Physiology and Biophysics, Vanderbilt University#N# School of Medicine, Nashville, Tennessee 37205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University#N# School of Medicine, Nashville, Tennessee 37205","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090188264","display_name":"Masakazu Shiota","orcid":"https://orcid.org/0009-0005-2801-1881","observed_orcids":["https://orcid.org/0009-0005-2801-1881"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masakazu Shiota","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205","Department of Molecular Physiology and Biophysics, Vanderbilt University#N# School of Medicine, Nashville, Tennessee 37205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37205","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University#N# School of Medicine, Nashville, Tennessee 37205","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018530141"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.1796,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.75475146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"278","issue":"35","first_page":"32485","last_page":"32488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.27320000529289246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.27320000529289246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.2531999945640564,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.14550000429153442,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-flux-control","display_name":"metabolic flux control","score":0.925000011920929},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.7300000190734863},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.859000027179718},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.844706654548645},{"id":"https://openalex.org/C98335778","wikidata":"https://www.wikidata.org/wiki/Q425185","display_name":"Glucokinase","level":3,"score":0.840583086013794},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.7166105508804321},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.6634315252304077},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.6300958395004272},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.5961188673973083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5410820841789246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5329227447509766},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.5298112630844116},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5207995176315308},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4971752464771271},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.45816993713378906},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44506099820137024},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42456063628196716},{"id":"https://openalex.org/C122245378","wikidata":"https://www.wikidata.org/wiki/Q14771739","display_name":"Phosphofructokinase","level":4,"score":0.41470208764076233},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3621389865875244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30648791790008545},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1552218496799469},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14790701866149902},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0838136076927185},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010729","descriptor_name":"Phosphoenolpyruvate Carboxykinase (GTP)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019764","descriptor_name":"Phosphoenolpyruvate Carboxykinase (ATP)","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.r300020200","doi":"https://doi.org/10.1074/jbc.r300020200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r300020200","pdf_url":"http://www.jbc.org/article/S0021925820837971/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12788933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12788933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.r300020200","doi":"https://doi.org/10.1074/jbc.r300020200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.r300020200","pdf_url":"http://www.jbc.org/article/S0021925820837971/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005398956.pdf","grobid_xml":"https://content.openalex.org/works/W2005398956.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W196268761","https://openalex.org/W1493756017","https://openalex.org/W1523158326","https://openalex.org/W1632767742","https://openalex.org/W1665938856","https://openalex.org/W1747247635","https://openalex.org/W1797186306","https://openalex.org/W1884901590","https://openalex.org/W1974878641","https://openalex.org/W1978248654","https://openalex.org/W1995030696","https://openalex.org/W1995856733","https://openalex.org/W2004495205","https://openalex.org/W2006090557","https://openalex.org/W2010827268","https://openalex.org/W2015739523","https://openalex.org/W2018442015","https://openalex.org/W2018901358","https://openalex.org/W2019927715","https://openalex.org/W2027117869","https://openalex.org/W2029378794","https://openalex.org/W2040661435","https://openalex.org/W2041195611","https://openalex.org/W2049016439","https://openalex.org/W2050051162","https://openalex.org/W2082046383","https://openalex.org/W2089437374","https://openalex.org/W2091822932","https://openalex.org/W2102252645","https://openalex.org/W2104791454","https://openalex.org/W2105748867","https://openalex.org/W2108814958","https://openalex.org/W2112022192","https://openalex.org/W2116209576","https://openalex.org/W2116887683","https://openalex.org/W2124148220","https://openalex.org/W2124697228","https://openalex.org/W2132005430","https://openalex.org/W2133208346","https://openalex.org/W2140137473","https://openalex.org/W2141698109","https://openalex.org/W2149300333","https://openalex.org/W2152312924","https://openalex.org/W2155715785","https://openalex.org/W2158112542","https://openalex.org/W2161641259","https://openalex.org/W2168929358","https://openalex.org/W2169482185","https://openalex.org/W2170772645","https://openalex.org/W2171952619","https://openalex.org/W2173366817","https://openalex.org/W2330339020","https://openalex.org/W2462327257"],"related_works":["https://openalex.org/W2130869775","https://openalex.org/W1966805292","https://openalex.org/W2306196896","https://openalex.org/W1985798801","https://openalex.org/W1431889553","https://openalex.org/W1595099194","https://openalex.org/W2085565962","https://openalex.org/W2053552604","https://openalex.org/W2432479461","https://openalex.org/W2069094961"],"abstract_inverted_index":{"The":[0,16],"regulation":[1],"of":[2,12,22,71,84],"metabolic":[3,27],"flux":[4,28],"is":[5,53],"essential":[6],"for":[7],"life,":[8],"yet":[9],"our":[10],"understanding":[11],"it":[13],"remains":[14],"incomplete.":[15],"ability":[17],"to":[18,36],"determine":[19],"the":[20,37,57,60,69],"role":[21],"specific":[23],"enzymes":[24,61],"in":[25,74],"regulating":[26],"rapidly":[29],"becomes":[30],"a":[31,75,82],"nearly":[32],"overwhelming":[33],"challenge":[34],"due":[35],"various":[38],"interacting":[39],"pathways,":[40],"multiple":[41,66],"enzyme":[42,73],"isoforms,":[43],"and":[44,86],"many":[45],"different":[46],"substrates":[47],"that":[48,59],"are":[49,63],"involved.":[50],"This":[51],"complexity":[52],"further":[54],"compounded":[55],"by":[56,65,81],"fact":[58],"themselves":[62],"regulated":[64],"mechanisms.":[67,88],"Moreover,":[68],"amount":[70],"an":[72],"particular":[76],"cell":[77],"may":[78],"be":[79],"modulated":[80],"variety":[83],"transcriptional":[85],"post-transcriptional":[87]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}