{"id":"https://openalex.org/W2005396826","doi":"https://doi.org/10.1097/00004347-198302000-00003","title":"Characterization of Human Choriocarcinoma Cell Lines Secreting High and Low Amounts of Chorionic Gonadotropin","display_name":"Characterization of Human Choriocarcinoma Cell Lines Secreting High and Low Amounts of Chorionic Gonadotropin","publication_year":1983,"publication_date":"1983-05-01","ids":{"openalex":"https://openalex.org/W2005396826","doi":"https://doi.org/10.1097/00004347-198302000-00003","mag":"2005396826","pmid":"https://pubmed.ncbi.nlm.nih.gov/6685113"},"language":"en","primary_location":{"id":"doi:10.1097/00004347-198302000-00003","doi":"https://doi.org/10.1097/00004347-198302000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004347-198302000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S45432028","display_name":"International Journal of Gynecological Pathology","issn_l":"0277-1691","issn":["0277-1691","1538-7151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111756982","display_name":"Souei Sekiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Sekiya","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111681952","display_name":"H. Iwasawa","orcid":"https://orcid.org/0009-0005-0631-7521","observed_orcids":["https://orcid.org/0009-0005-0631-7521"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Iwasawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064272534","display_name":"Michio Sugita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Sugita","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014800098","display_name":"Noriyuki Inaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Inaba","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051103531","display_name":"T Kaiho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kaiho","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113571818","display_name":"S Shirotake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Shirotake","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111366658","display_name":"H Takamizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Takamizawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5326,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.94834504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"2","first_page":"121","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endoplasmic-reticulum-dilation","display_name":"endoplasmic reticulum dilation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/glycogen-accumulation","display_name":"glycogen accumulation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/s-phase-accumulation","display_name":"S phase accumulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2780832733","wikidata":"https://www.wikidata.org/wiki/Q1076481","display_name":"Choriocarcinoma","level":2,"score":0.631773829460144},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.6210083961486816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.605017364025116},{"id":"https://openalex.org/C136403682","wikidata":"https://www.wikidata.org/wiki/Q5796041","display_name":"Multinucleate","level":2,"score":0.5962026119232178},{"id":"https://openalex.org/C2779315647","wikidata":"https://www.wikidata.org/wiki/Q2745412","display_name":"Syncytiotrophoblast","level":5,"score":0.5520414113998413},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5365709066390991},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5317439436912537},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5254729986190796},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44833898544311523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42204606533050537},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.421102374792099},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4113011360168457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36532068252563477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35849058628082275},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3103158473968506},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.18013232946395874},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.1266595423221588},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10004520416259766},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0759601891040802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07249680161476135},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.07074400782585144},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002822","descriptor_name":"Choriocarcinoma","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004347-198302000-00003","doi":"https://doi.org/10.1097/00004347-198302000-00003","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004347-198302000-00003","pdf_url":null,"source":{"id":"https://openalex.org/S45432028","display_name":"International Journal of Gynecological Pathology","issn_l":"0277-1691","issn":["0277-1691","1538-7151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Pathology","raw_type":"journal-article"},{"id":"pmid:6685113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6685113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1924995011","https://openalex.org/W2086733266","https://openalex.org/W2169653086","https://openalex.org/W2075187399","https://openalex.org/W603907434","https://openalex.org/W1945210702","https://openalex.org/W1984564594","https://openalex.org/W1535241508","https://openalex.org/W1988075863","https://openalex.org/W2413042077"],"abstract_inverted_index":{"The":[0],"secretory":[1,25,110],"potential":[2,26,111],"of":[3,11,52,55,73,80,92,100,116],"human":[4,12],"chorionic":[5],"gonadotropin":[6],"(hCG)":[7],"in":[8,18,43,48,65,120],"eight":[9],"strains":[10],"choriocarcinoma":[13],"cell":[14,29,46,76,118],"lines":[15,47,119],"was":[16,32,105],"examined":[17],"vitro":[19],"and":[20,27,61,88,112],"the":[21,24,66,108,117],"correlation":[22,104],"between":[23,107],"certain":[28],"biological":[30],"characteristics":[31,72],"studied.":[33],"Multinucleated":[34],"giant":[35],"cells":[36,93],"(syncytiotrophoblast-like":[37],"cells)":[38],"were":[39,97],"occasionally":[40],"observed":[41],"only":[42],"high":[44,74],"hCG-secreting":[45,75],"accordance":[49],"with":[50],"inhibition":[51],"growth.":[53],"Appearance":[54],"abundant":[56],"dilated":[57],"rough":[58],"endoplasmic":[59],"reticulum":[60],"aggregated":[62],"glycogen":[63],"particles":[64],"cytoplasm":[67],"seemed":[68],"to":[69,83],"represent":[70],"ultrastructural":[71],"lines.":[77],"A":[78],"shift":[79],"nuclear":[81],"DNA":[82],"hyperploidy,":[84],"its":[85],"wide":[86],"distribution,":[87],"S":[89],"phase":[90],"accumulation":[91],"by":[94],"flow":[95],"cytometry":[96],"also":[98],"characteristic":[99],"them.":[101],"However,":[102],"no":[103],"noted":[106],"hCG":[109],"population":[113],"doubling":[114],"time":[115],"vitro.":[121]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}