{"id":"https://openalex.org/W2005395865","doi":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","title":"Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin","display_name":"Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin","publication_year":1975,"publication_date":"1975-11-01","ids":{"openalex":"https://openalex.org/W2005395865","doi":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","mag":"2005395865","pmid":"https://pubmed.ncbi.nlm.nih.gov/172214"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","doi":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197511%2936%3A5%3C1577%3A%3AAID-CNCR2820360507%3E3.0.CO%3B2-B","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197511%2936%3A5%3C1577%3A%3AAID-CNCR2820360507%3E3.0.CO%3B2-B","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107824929","display_name":"James P. Kushner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James P. Kushner","raw_affiliation_strings":["Assistant Professor of Medicine","The Departments of Medicine and Pathology, the University of Utah College of Medicine and the Veterans Administration Hospital, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Medicine","institution_ids":[]},{"raw_affiliation_string":"The Departments of Medicine and Pathology, the University of Utah College of Medicine and the Veterans Administration Hospital, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058019518","display_name":"Vincent L. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent L. Hansen","raw_affiliation_strings":["Fellow in Hematology","The Departments of Medicine and Pathology, the University of Utah College of Medicine and the Veterans Administration Hospital, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fellow in Hematology","institution_ids":[]},{"raw_affiliation_string":"The Departments of Medicine and Pathology, the University of Utah College of Medicine and the Veterans Administration Hospital, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003137749","display_name":"Samuel P. Hammar","orcid":"https://orcid.org/0000-0002-3798-8097","observed_orcids":["https://orcid.org/0000-0002-3798-8097"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel P. Hammar","raw_affiliation_strings":["Assistant Professor of Pathology","The Departments of Medicine and Pathology, the University of Utah College of Medicine and the Veterans Administration Hospital, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Pathology","institution_ids":[]},{"raw_affiliation_string":"The Departments of Medicine and Pathology, the University of Utah College of Medicine and the Veterans Administration Hospital, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5107824929"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":6.5599,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.96400475,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"36","issue":"5","first_page":"1577","last_page":"1584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adriamycin-cardiomyopathy","display_name":"adriamycin cardiomyopathy","score":0.9470000267028809},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.902999997138977},{"id":"https://openalex.org/keywords/mithramycin","display_name":"mithramycin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antitumor-antibiotics","display_name":"antitumor antibiotics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/drug-induced-cardiotoxicity","display_name":"drug-induced cardiotoxicity","score":0.6800000071525574},{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cumulative-dose","display_name":"cumulative dose","score":0.5},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9459999799728394},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8859186172485352},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.755495011806488},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.7261042594909668},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6991852521896362},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5975700616836548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4909663498401642},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4196814000606537},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.41404831409454346},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4071020483970642},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3729451298713684}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008926","descriptor_name":"Plicamycin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013584","descriptor_name":"Sarcoma, Synovial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","doi":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197511%2936%3A5%3C1577%3A%3AAID-CNCR2820360507%3E3.0.CO%3B2-B","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:172214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/172214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","doi":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(197511)36:5<1577::aid-cncr2820360507>3.0.co;2-b","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%28197511%2936%3A5%3C1577%3A%3AAID-CNCR2820360507%3E3.0.CO%3B2-B","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005395865.pdf","grobid_xml":"https://content.openalex.org/works/W2005395865.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W241116528","https://openalex.org/W1513425511","https://openalex.org/W1977138227","https://openalex.org/W2007409269","https://openalex.org/W2013812998","https://openalex.org/W2020893327","https://openalex.org/W2024841231","https://openalex.org/W2033734515","https://openalex.org/W2034255683","https://openalex.org/W2043902165","https://openalex.org/W2064722407","https://openalex.org/W2074706094","https://openalex.org/W2084485840","https://openalex.org/W2111426313","https://openalex.org/W2123184457","https://openalex.org/W2142596760","https://openalex.org/W2144708655","https://openalex.org/W2162157258","https://openalex.org/W2402180009","https://openalex.org/W2403928882","https://openalex.org/W2409710502"],"related_works":["https://openalex.org/W2111426313","https://openalex.org/W7035910491","https://openalex.org/W2167397260","https://openalex.org/W1977105311","https://openalex.org/W4231344364","https://openalex.org/W119184795","https://openalex.org/W200808907","https://openalex.org/W7095374373","https://openalex.org/W2020153416","https://openalex.org/W4302048276"],"abstract_inverted_index":{"A":[0],"22-year-old":[1],"man":[2],"with":[3,14,42],"a":[4,26,54,111],"synovial":[5],"cell":[6],"sarcoma":[7],"attained":[8],"an":[9],"excellent":[10],"response":[11],"to":[12,84,119],"therapy":[13,41,50],"adriamycin":[15,30,43,58,106,137],"(NSC-123127)":[16],"and":[17,40,93,141],"dimethyltriazeno":[18],"imidazole":[19],"carboxamide":[20],"(NSC-45388).":[21],"Therapy":[22],"was":[23,44,51],"discontinued":[24,52],"at":[25],"cumulative":[27,55,124],"dose":[28,56,125],"of":[29,31,47,57,59,77,87,99,105,127,136,146],"600":[32],"mg/m2.":[33,61],"Relapse":[34],"occurred":[35],"13":[36],"1/2":[37],"months":[38],"later,":[39,64],"restarted.":[45],"Because":[46],"tumor":[48],"progression,":[49],"after":[53,110],"120":[60],"Ten":[62],"weeks":[63],"severe":[65],"congestive":[66],"heart":[67,79,101],"failure":[68,80],"developed":[69],"which":[70],"ultimately":[71],"caused":[72],"the":[73,78,85,88,100,121,134,142],"patient's":[74],"death.":[75],"Exacerbations":[76],"were":[81],"temporally":[82],"related":[83],"administration":[86],"antitumor":[89,148],"antibiotics":[90,149],"actinomycin-D":[91],"(NSC-3053)":[92],"mithramycin":[94],"(NSC-24559).":[95],"Electron":[96],"microscopic":[97],"examination":[98],"revealed":[102],"changes":[103],"characteristic":[104],"cardiomyopathy.":[107],"Thus,":[108],"even":[109],"long":[112],"hiatus,":[113],"it":[114],"may":[115],"not":[116],"be":[117],"safe":[118],"exceed":[120],"recommended":[122],"maximum":[123],"level":[126],"adriamycin.":[128],"The":[129],"pathogenic":[130],"mechanisms":[131],"involved":[132],"in":[133],"development":[135],"cardiomyopathy":[138],"are":[139],"reviewed,":[140],"possible":[143],"synergistic":[144],"effect":[145],"other":[147],"is":[150],"discussed.":[151]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}