{"id":"https://openalex.org/W2005390061","doi":"https://doi.org/10.4155/tde.10.61","title":"Intracellular Delivery of RNA-based Therapeutics Using Aptamers","display_name":"Intracellular Delivery of RNA-based Therapeutics Using Aptamers","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2005390061","doi":"https://doi.org/10.4155/tde.10.61","mag":"2005390061","pmid":"https://pubmed.ncbi.nlm.nih.gov/21643487","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3106310"},"language":"en","primary_location":{"id":"doi:10.4155/tde.10.61","doi":"https://doi.org/10.4155/tde.10.61","is_oa":false,"landing_page_url":"https://doi.org/10.4155/tde.10.61","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3106310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043390661","display_name":"Kristina W. Thiel","orcid":"https://orcid.org/0000-0001-8295-864X","observed_orcids":["https://orcid.org/0000-0001-8295-864X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina W Thiel","raw_affiliation_strings":["Department of Internal Medicine, Department of Radiation Oncology, 375 Newton Rd, 5202 MERF, Iowa City, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Department of Radiation Oncology, 375 Newton Rd, 5202 MERF, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049231735","display_name":"Paloma H. Giangrande","orcid":"https://orcid.org/0000-0002-6559-3308","observed_orcids":["https://orcid.org/0000-0002-6559-3308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paloma H Giangrande","raw_affiliation_strings":["Department of Internal Medicine Department of Radiation Oncology\r375 Newton Rd\r5202 MERF\rIowa City\rIA\r52242\rUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Department of Radiation Oncology\r375 Newton Rd\r5202 MERF\rIowa City\rIA\r52242\rUSA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5933,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.48233562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"1","issue":"6","first_page":"849","last_page":"861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-aptamers","display_name":"RNA aptamers","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.972000002861023},{"id":"https://openalex.org/keywords/intracellular-delivery","display_name":"intracellular delivery","score":0.7110000252723694},{"id":"https://openalex.org/keywords/rna-therapeutics","display_name":"RNA therapeutics","score":0.7310000061988831},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.6579999923706055},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":1.0},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/hiv-treatment","display_name":"HIV treatment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9359220266342163},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.809195876121521},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7073229551315308},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6871539354324341},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6214881539344788},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5393637418746948},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5115340948104858},{"id":"https://openalex.org/C60723119","wikidata":"https://www.wikidata.org/wiki/Q7833577","display_name":"Trans-acting siRNA","level":5,"score":0.4795803129673004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4205087423324585},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.34307432174682617},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3316255807876587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2670820951461792},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.19640576839447021},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13744977116584778},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.082795649766922}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4155/tde.10.61","doi":"https://doi.org/10.4155/tde.10.61","is_oa":false,"landing_page_url":"https://doi.org/10.4155/tde.10.61","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},{"id":"pmid:21643487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21643487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic delivery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3106310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3106310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ther Deliv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3106310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3106310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Ther Deliv","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1960570497","display_name":"Aptamer-siRNA Chimeras Targeting HER2-Positive Breast Cancers","funder_award_id":"R01CA138503","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8175958115","display_name":"Novel Chimeric RNA Aptamer Technology to Treat Head and Neck Cancer","funder_award_id":"R21DE019953","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000861791","display_name":"Program in Hematology:  Molecular & Cell Biology of Blood Cells","funder_award_id":"T32HL007344","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W14759517","https://openalex.org/W1506041617","https://openalex.org/W1529854703","https://openalex.org/W1556322054","https://openalex.org/W1558144205","https://openalex.org/W1592020922","https://openalex.org/W1875906722","https://openalex.org/W1980585134","https://openalex.org/W1992834282","https://openalex.org/W1994475760","https://openalex.org/W1996517412","https://openalex.org/W1999330068","https://openalex.org/W2002008977","https://openalex.org/W2002961521","https://openalex.org/W2003015405","https://openalex.org/W2008819279","https://openalex.org/W2009318927","https://openalex.org/W2012298966","https://openalex.org/W2014909608","https://openalex.org/W2015839993","https://openalex.org/W2019555018","https://openalex.org/W2019631541","https://openalex.org/W2021110283","https://openalex.org/W2023373190","https://openalex.org/W2027225984","https://openalex.org/W2030621748","https://openalex.org/W2033013069","https://openalex.org/W2034037652","https://openalex.org/W2035264169","https://openalex.org/W2038167103","https://openalex.org/W2040207304","https://openalex.org/W2041887649","https://openalex.org/W2044359179","https://openalex.org/W2044824066","https://openalex.org/W2046002563","https://openalex.org/W2046619729","https://openalex.org/W2046802601","https://openalex.org/W2046851174","https://openalex.org/W2047165821","https://openalex.org/W2051548433","https://openalex.org/W2056285082","https://openalex.org/W2057348359","https://openalex.org/W2059814129","https://openalex.org/W2061279639","https://openalex.org/W2062918977","https://openalex.org/W2064036940","https://openalex.org/W2066074720","https://openalex.org/W2070693578","https://openalex.org/W2072889836","https://openalex.org/W2073066818","https://openalex.org/W2079321730","https://openalex.org/W2081347075","https://openalex.org/W2082984134","https://openalex.org/W2087898800","https://openalex.org/W2088223764","https://openalex.org/W2091632168","https://openalex.org/W2092049057","https://openalex.org/W2093065590","https://openalex.org/W2095151181","https://openalex.org/W2097535374","https://openalex.org/W2097623122","https://openalex.org/W2099001057","https://openalex.org/W2102110918","https://openalex.org/W2103311193","https://openalex.org/W2104525153","https://openalex.org/W2105668301","https://openalex.org/W2109764004","https://openalex.org/W2110725987","https://openalex.org/W2112000341","https://openalex.org/W2112381014","https://openalex.org/W2113091464","https://openalex.org/W2113515822","https://openalex.org/W2116424844","https://openalex.org/W2120070003","https://openalex.org/W2120145250","https://openalex.org/W2123175900","https://openalex.org/W2123922022","https://openalex.org/W2124018243","https://openalex.org/W2124258497","https://openalex.org/W2128689552","https://openalex.org/W2129360146","https://openalex.org/W2130501958","https://openalex.org/W2133952187","https://openalex.org/W2135508499","https://openalex.org/W2136797728","https://openalex.org/W2136991395","https://openalex.org/W2137109655","https://openalex.org/W2138465485","https://openalex.org/W2138612986","https://openalex.org/W2138733854","https://openalex.org/W2145871683","https://openalex.org/W2149147994","https://openalex.org/W2155192875","https://openalex.org/W2156536464","https://openalex.org/W2158583121"],"related_works":["https://openalex.org/W2099001057","https://openalex.org/W2743939733","https://openalex.org/W7099706834","https://openalex.org/W1976100156","https://openalex.org/W2886915507","https://openalex.org/W2365197427","https://openalex.org/W2477181187","https://openalex.org/W2049567853","https://openalex.org/W2352259598","https://openalex.org/W153615423"],"abstract_inverted_index":{"The":[0],"clinical":[1],"potential":[2],"of":[3,24,36,56,83,97,107,110],"siRNAs":[4,20,47],"for":[5,18,73,94,104],"silencing":[6],"genes":[7],"critical":[8],"to":[9,21,31,42,48,66],"disease":[10],"progression":[11],"is":[12],"clear,":[13],"but":[14],"a":[15,64],"fail-proof":[16],"method":[17],"delivering":[19],"the":[22,54,79,95,105],"cytoplasm":[23],"diseased":[25],"tissues":[26],"or":[27,44],"cells":[28],"has":[29],"yet":[30],"be":[32],"identified.":[33],"A":[34],"variety":[35],"delivery":[37,49,87,92],"approaches":[38],"have":[39],"been":[40],"explored":[41],"directly":[43],"indirectly":[45],"couple":[46],"vehicles.":[50],"This":[51],"review":[52],"explores":[53],"use":[55],"synthetic":[57],"single-stranded":[58],"DNA":[59],"and":[60,70,81,99,101],"RNA":[61],"aptamers":[62,85,108],"as":[63,86],"means":[65],"deliver":[67],"siRNAs,":[68],"shRNAs":[69],"antisense":[71],"oligonucleotides":[72],"therapeutic":[74],"intervention.":[75],"Topics":[76],"covered":[77],"include:":[78],"advantages":[80],"challenges":[82],"using":[84],"tools;":[88],"current":[89],"aptamer-mediated":[90],"siRNA":[91],"platforms":[93],"treatment":[96],"cancer":[98],"HIV;":[100],"emerging":[102],"methodologies":[103],"identification":[106],"capable":[109],"internalizing":[111],"into":[112],"target":[113],"cell":[114],"types.":[115]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}