{"id":"https://openalex.org/W2005389118","doi":"https://doi.org/10.1074/jbc.m110233200","title":"HMGB1 and HMGB2 Cell-specifically Down-regulate the p53- and p73-dependent Sequence-specific Transactivation from the Human Bax Gene Promoter","display_name":"HMGB1 and HMGB2 Cell-specifically Down-regulate the p53- and p73-dependent Sequence-specific Transactivation from the Human Bax Gene Promoter","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2005389118","doi":"https://doi.org/10.1074/jbc.m110233200","mag":"2005389118","pmid":"https://pubmed.ncbi.nlm.nih.gov/11748232"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110233200","doi":"https://doi.org/10.1074/jbc.m110233200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110233200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005389118"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m110233200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090892593","display_name":"Michal \u0160tros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michal \u0160tros","raw_affiliation_strings":["Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolsk\u00e1 135, 612 65 Brno, Czech Republic. stros@ibp.cs","Institute of Biophysics, Academy of Sciences of the Czech Republic, Kr\u00e1lovopolsk\u00e1 135, 612 65 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolsk\u00e1 135, 612 65 Brno, Czech Republic. stros@ibp.cs","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]},{"raw_affiliation_string":"Institute of Biophysics, Academy of Sciences of the Czech Republic, Kr\u00e1lovopolsk\u00e1 135, 612 65 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034252509","display_name":"Toshinori Ozaki","orcid":"https://orcid.org/0000-0002-1612-7394","observed_orcids":["https://orcid.org/0000-0002-1612-7394"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshinori Ozaki","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091484542","display_name":"Alena Ba\u010d\u00edkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Alena Ba\u010d\u0131\u0301kov\u00e1","raw_affiliation_strings":["Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004803822","display_name":"Hajime Kageyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Kageyama","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059436010","display_name":"Akira Nakagawara","orcid":"https://orcid.org/0000-0002-7117-9429","observed_orcids":["https://orcid.org/0000-0002-7117-9429"]},"institutions":[{"id":"https://openalex.org/I4210115246","display_name":"Chiba Cancer Center","ror":"https://ror.org/02120t614","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115246"]},{"id":"https://openalex.org/I4405286631","display_name":"Chiba Cancer Center Research Institute","ror":"https://ror.org/02p9eh956","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Nakagawara","raw_affiliation_strings":["Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan","institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059436010"],"corresponding_institution_ids":["https://openalex.org/I4210115246","https://openalex.org/I4405286631"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.7213,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.93063174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"277","issue":"9","first_page":"7157","last_page":"7164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":1.0},{"id":"https://openalex.org/keywords/hmgb2","display_name":"HMGB2","score":1.0},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8299999833106995},{"id":"https://openalex.org/keywords/p73","display_name":"p73","score":0.9919999837875366},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/p53-response-element","display_name":"p53 response elements","score":0.6779999732971191},{"id":"https://openalex.org/keywords/hmg-box-domain","display_name":"HMG-box domain","score":0.7300000190734863},{"id":"https://openalex.org/keywords/p53-family","display_name":"p53 family","score":0.593999981880188},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6759999990463257},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.7599999904632568},{"id":"https://openalex.org/keywords/h1299-cells","display_name":"H1299 cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/antisense-knockdown","display_name":"antisense knockdown","score":0.5}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.8841379880905151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6416019797325134},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5748113393783569},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4758555591106415},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4751206040382385},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4745543599128723},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45809206366539},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4461270570755005},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4270310401916504},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2382086217403412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1848321557044983},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072160","descriptor_name":"Tumor Protein p73","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016329","descriptor_name":"Sp1 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024261","descriptor_name":"HMGB2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m110233200","doi":"https://doi.org/10.1074/jbc.m110233200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110233200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:11748232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11748232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110233200","doi":"https://doi.org/10.1074/jbc.m110233200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110233200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W73359563","https://openalex.org/W1493378336","https://openalex.org/W1519947104","https://openalex.org/W1524615273","https://openalex.org/W1525929664","https://openalex.org/W1590583667","https://openalex.org/W1822420866","https://openalex.org/W1837125915","https://openalex.org/W1967167923","https://openalex.org/W1968044233","https://openalex.org/W1969826234","https://openalex.org/W1972293204","https://openalex.org/W1975618936","https://openalex.org/W1983386156","https://openalex.org/W1985064409","https://openalex.org/W1987520716","https://openalex.org/W1987534706","https://openalex.org/W1992115246","https://openalex.org/W1997054462","https://openalex.org/W1997837993","https://openalex.org/W2010645034","https://openalex.org/W2036702562","https://openalex.org/W2040394268","https://openalex.org/W2044804986","https://openalex.org/W2045086385","https://openalex.org/W2051136861","https://openalex.org/W2053462331","https://openalex.org/W2055033922","https://openalex.org/W2058737236","https://openalex.org/W2059334120","https://openalex.org/W2064795157","https://openalex.org/W2069357145","https://openalex.org/W2080883315","https://openalex.org/W2081552644","https://openalex.org/W2082961480","https://openalex.org/W2088445980","https://openalex.org/W2088793065","https://openalex.org/W2089230894","https://openalex.org/W2090213064","https://openalex.org/W2090438409","https://openalex.org/W2090995659","https://openalex.org/W2096638364","https://openalex.org/W2098493499","https://openalex.org/W2106031335","https://openalex.org/W2107097615","https://openalex.org/W2117489086","https://openalex.org/W2138068224","https://openalex.org/W2145260507","https://openalex.org/W2148119650","https://openalex.org/W2151085515","https://openalex.org/W2151277769","https://openalex.org/W2152105234","https://openalex.org/W2155740016","https://openalex.org/W2159416234","https://openalex.org/W2325290815"],"related_works":["https://openalex.org/W2790120427","https://openalex.org/W2083631669","https://openalex.org/W2919958596","https://openalex.org/W2137361600","https://openalex.org/W1480852720","https://openalex.org/W2138068224","https://openalex.org/W3031862512","https://openalex.org/W7024561852","https://openalex.org/W2085317811"],"abstract_inverted_index":{"The":[0],"recently":[1],"cloned":[2],"gene":[3,17,180],"p73":[4,100,133,152],"is":[5,12,253],"a":[6,13,53],"close":[7],"homologue":[8],"of":[9,23,55,89,99,112,121,129,151,209,235,238,245,248],"p53,":[10],"which":[11,50],"crucial":[14],"tumor":[15],"suppressor":[16],"for":[18],"preventing":[19],"the":[20,126,140,178,210,239],"malignant":[21],"transformation":[22],"cells":[24],"by":[25],"inducing":[26],"cell":[27],"cycle":[28],"arrest":[29],"and":[30,42,48,60,68,92,96,115,148,164,174,187,197,220,226,250],"apoptosis.":[31],"Previous":[32],"reports":[33],"have":[34,222],"shown":[35],"that":[36,81,158,216],"architectural":[37],"DNA-bending/looping":[38],"chromosomal":[39],"proteins":[40],"HMGB1":[41,82,122,130,163,196,219],"HMGB2":[43,165,221],"(formerly":[44],"known":[45],"as":[46],"HMG1":[47],"HMG2),":[49],"function":[51],"in":[52,64,170,190,204,231],"number":[54],"biological":[56],"processes":[57],"including":[58],"transcription":[59],"DNA":[61,73,104],"repair,":[62],"interact":[63,117],"vitro":[65],"with":[66,85,118,123],"p53":[67,70,75,240],"stimulate":[69,132,199],"binding":[71,98,134],"to":[72,101,131,135,224],"containing":[74],"consensus":[76],"sites.":[77],"Here,":[78],"we":[79],"report":[80],"physically":[83],"interacts":[84],"two":[86],"splicing":[87],"variants":[88],"p73,":[90,124],"alpha":[91],"beta":[93],"(pull-down":[94],"assay),":[95],"enhances":[97],"specific":[102],"cognate":[103],"sites":[105],"(gel-shift":[106],"assay).":[107],"Both":[108],"HMG":[109],"box":[110],"domains":[111],"HMGB1,":[113],"A":[114,242],"B,":[116],"p73alpha.":[119],"Association":[120],"like":[125],"demonstrated":[127],"ability":[128],"different":[136,236],"p53-responsive":[137],"elements,":[138],"requires":[139],"oligomerization":[141,149],"region":[142,144],"and/or":[143],"between":[145],"DNA-binding":[146],"domain":[147,150],"(residues":[153],"312-381).":[154],"Transient":[155],"transfections":[156],"revealed":[157],"ectopically":[159],"expressed":[160,218],"or":[161,201,229],"endogenous":[162],"(antisense":[166],"strategy)":[167],"significantly":[168],"inhibit":[169],"vivo":[171,232],"both":[172],"p73alpha/beta-":[173],"p53-dependent":[175,202,251],"transactivation":[176,203,252],"from":[177,185],"Bax":[179],"promoter":[181,211],"(and":[182],"much":[183],"less":[184],"Mdm2":[186],"p21(waf1)":[188],"promoters)":[189],"p53-deficient":[191,205],"SAOS-2":[192],"cells.":[193],"In":[194],"contrast,":[195],"HGMB2":[198],"p73-":[200,249],"H1299":[206],"cells,":[207],"irrespective":[208],"used.":[212],"Our":[213],"results":[214],"suggest":[215],"ubiquitously":[217],"potential":[223],"cell-":[225],"promoter-specifically":[227],"down-":[228],"up-regulate":[230],"transcriptional":[233],"activity":[234],"members":[237],"family.":[241],"possible":[243],"mechanism":[244],"HMGB1-mediated":[246],"modulation":[247],"discussed.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}