{"id":"https://openalex.org/W2005388108","doi":"https://doi.org/10.1016/s1741-8372(04)02428-4","title":"Zebrafish as a model system for drug target screening and validation","display_name":"Zebrafish as a model system for drug target screening and validation","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2005388108","doi":"https://doi.org/10.1016/s1741-8372(04)02428-4","mag":"2005388108"},"language":"en","primary_location":{"id":"doi:10.1016/s1741-8372(04)02428-4","doi":"https://doi.org/10.1016/s1741-8372(04)02428-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1741-8372(04)02428-4","pdf_url":null,"source":{"id":"https://openalex.org/S155923265","display_name":"Drug Discovery Today TARGETS","issn_l":"1741-8372","issn":["1741-8372","1878-7363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today: TARGETS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019737130","display_name":"Saulius Sumanas","orcid":"https://orcid.org/0000-0002-8605-6122","observed_orcids":["https://orcid.org/0000-0002-8605-6122"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saulius Sumanas","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, 621 C. Young Dr. South, Los Angeles, CA 90095, USA","University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, 621 C. Young Dr. South, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101997641","display_name":"Shuo Lin","orcid":"https://orcid.org/0000-0003-2317-0339","observed_orcids":["https://orcid.org/0000-0003-2317-0339"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuo Lin","raw_affiliation_strings":["Department of Molecular, Cell and Developmental Biology, 621 C. Young Dr. South, Los Angeles, CA 90095, USA","University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cell and Developmental Biology, 621 C. Young Dr. South, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101997641"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":0.5933,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.63027435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"3","first_page":"89","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9879999756813049},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-target-validation","display_name":"drug target validation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemical-mutagenesis","display_name":"chemical mutagenesis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/insertional-mutagenesis","display_name":"insertional mutagenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/small-molecule-screening","display_name":"small molecule screening","score":0.8949999809265137},{"id":"https://openalex.org/keywords/morpholino-knockdown","display_name":"morpholino knockdown","score":0.9929999709129333},{"id":"https://openalex.org/keywords/zebrafish-disease-models","display_name":"zebrafish disease models","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9482417106628418},{"id":"https://openalex.org/C107635520","wikidata":"https://www.wikidata.org/wiki/Q1967554","display_name":"Insertional mutagenesis","level":4,"score":0.8557460904121399},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7470093965530396},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6911810636520386},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.6870884895324707},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6160733699798584},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47634008526802063},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.4671914577484131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42727863788604736},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2629845142364502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19689041376113892},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.196637362241745},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14084237813949585},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.12141406536102295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09136298298835754}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1741-8372(04)02428-4","doi":"https://doi.org/10.1016/s1741-8372(04)02428-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1741-8372(04)02428-4","pdf_url":null,"source":{"id":"https://openalex.org/S155923265","display_name":"Drug Discovery Today TARGETS","issn_l":"1741-8372","issn":["1741-8372","1878-7363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today: TARGETS","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1484307555","https://openalex.org/W1495901582","https://openalex.org/W1543863358","https://openalex.org/W1546386885","https://openalex.org/W1549559463","https://openalex.org/W1932232911","https://openalex.org/W1933480341","https://openalex.org/W1943362480","https://openalex.org/W1964814516","https://openalex.org/W1966435498","https://openalex.org/W1968300340","https://openalex.org/W1972999344","https://openalex.org/W1977353721","https://openalex.org/W1979771830","https://openalex.org/W1981829733","https://openalex.org/W1984222668","https://openalex.org/W1994279105","https://openalex.org/W1994858921","https://openalex.org/W1995697852","https://openalex.org/W1996789388","https://openalex.org/W1998756807","https://openalex.org/W2002937223","https://openalex.org/W2009476579","https://openalex.org/W2018753432","https://openalex.org/W2028571259","https://openalex.org/W2042592516","https://openalex.org/W2059470587","https://openalex.org/W2062186255","https://openalex.org/W2066962376","https://openalex.org/W2070818399","https://openalex.org/W2075549508","https://openalex.org/W2082609114","https://openalex.org/W2091744502","https://openalex.org/W2092181373","https://openalex.org/W2092670526","https://openalex.org/W2102354071","https://openalex.org/W2104541511","https://openalex.org/W2104809172","https://openalex.org/W2106303663","https://openalex.org/W2109483208","https://openalex.org/W2113325631","https://openalex.org/W2114451767","https://openalex.org/W2115591173","https://openalex.org/W2117648777","https://openalex.org/W2118995117","https://openalex.org/W2121676856","https://openalex.org/W2123938765","https://openalex.org/W2124752518","https://openalex.org/W2132531056","https://openalex.org/W2141279088","https://openalex.org/W2141735759","https://openalex.org/W2143616168","https://openalex.org/W2143952155","https://openalex.org/W2147553368","https://openalex.org/W2148335222","https://openalex.org/W2148985319","https://openalex.org/W2151231857","https://openalex.org/W2160375991","https://openalex.org/W2161653543","https://openalex.org/W2164618384","https://openalex.org/W2166112617","https://openalex.org/W2169872397","https://openalex.org/W2280816045","https://openalex.org/W2318201098","https://openalex.org/W2338417323","https://openalex.org/W4213254864","https://openalex.org/W4297846793"],"related_works":["https://openalex.org/W1548006771","https://openalex.org/W1997989074","https://openalex.org/W2005889545","https://openalex.org/W2737154607","https://openalex.org/W2411086326","https://openalex.org/W4287545843","https://openalex.org/W3128073476","https://openalex.org/W4211197781","https://openalex.org/W2118010755","https://openalex.org/W2911511793"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}