{"id":"https://openalex.org/W2005386937","doi":"https://doi.org/10.1128/aac.01164-07","title":"Spontaneous Deletion of the Methicillin Resistance Determinant, mecA , Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus","display_name":"Spontaneous Deletion of the Methicillin Resistance Determinant, mecA , Partially Compensates for the Fitness Cost Associated with High-Level Vancomycin Resistance in Staphylococcus aureus","publication_year":2008,"publication_date":"2008-01-23","ids":{"openalex":"https://openalex.org/W2005386937","doi":"https://doi.org/10.1128/aac.01164-07","mag":"2005386937","pmid":"https://pubmed.ncbi.nlm.nih.gov/18212094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2292509"},"language":"en","primary_location":{"id":"doi:10.1128/aac.01164-07","doi":"https://doi.org/10.1128/aac.01164-07","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.01164-07","pdf_url":"https://aac.asm.org/content/aac/52/4/1221.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/52/4/1221.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019489707","display_name":"Michael J. Noto","orcid":"https://orcid.org/0000-0002-5349-6316","observed_orcids":["https://orcid.org/0000-0002-5349-6316"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Noto","raw_affiliation_strings":["Department of Microbiology and Immunology","Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, McGuire Hall Room 103, 1112 East Clay Street, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, McGuire Hall Room 103, 1112 East Clay Street, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015349104","display_name":"Paige M. Fox","orcid":"https://orcid.org/0000-0002-4166-8547","observed_orcids":["https://orcid.org/0000-0002-4166-8547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paige M. Fox","raw_affiliation_strings":["Department of Microbiology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013985685","display_name":"Gordon L. Archer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gordon L. Archer","raw_affiliation_strings":["Internal Medicine, Virginia Commonwealth University School of Medicine, McGuire Hall Room 103, 1112 East Clay Street, Richmond, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Virginia Commonwealth University School of Medicine, McGuire Hall Room 103, 1112 East Clay Street, Richmond, Virginia","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013985685"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"],"apc_list":null,"apc_paid":null,"fwci":4.5238,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.94286965,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"52","issue":"4","first_page":"1221","last_page":"1229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/methicillin-resistance","display_name":"methicillin resistance","score":0.8569999933242798},{"id":"https://openalex.org/keywords/meca","display_name":"mecA gene","score":0.7590000033378601},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sccmec","display_name":"staphylococcal cassette chromosome mec","score":0.875},{"id":"https://openalex.org/keywords/fitness-cost","display_name":"fitness cost","score":0.9100000262260437},{"id":"https://openalex.org/keywords/antibiotic-resistance-evolution","display_name":"antibiotic resistance evolution","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7599958181381226},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7277801036834717},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.612626314163208},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.6076611280441284},{"id":"https://openalex.org/C2775965595","wikidata":"https://www.wikidata.org/wiki/Q1365581","display_name":"Micrococcaceae","level":4,"score":0.4429800510406494},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.4080927073955536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38523396849632263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3806793689727783},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3616117238998413},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.265211820602417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22597992420196533}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016106","descriptor_name":"Methicillin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020713","descriptor_name":"Vancomycin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020713","descriptor_name":"Vancomycin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020713","descriptor_name":"Vancomycin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046915","descriptor_name":"Penicillin-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.01164-07","doi":"https://doi.org/10.1128/aac.01164-07","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.01164-07","pdf_url":"https://aac.asm.org/content/aac/52/4/1221.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2292509","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2292509","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:18212094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18212094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/aac.01164-07","doi":"https://doi.org/10.1128/aac.01164-07","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.01164-07","pdf_url":"https://aac.asm.org/content/aac/52/4/1221.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.44999998807907104}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1699341535","display_name":"Staphylococcal methicillin resistance locus","funder_award_id":"R01AI035705","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2739861831","display_name":null,"funder_award_id":"5R01AI35705-13","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2005386937.pdf"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1505626160","https://openalex.org/W1527353036","https://openalex.org/W1581962345","https://openalex.org/W1591645875","https://openalex.org/W1908139426","https://openalex.org/W1966079578","https://openalex.org/W1966856181","https://openalex.org/W1969876530","https://openalex.org/W1982425296","https://openalex.org/W1988681379","https://openalex.org/W1993364817","https://openalex.org/W2047004951","https://openalex.org/W2068037991","https://openalex.org/W2069111254","https://openalex.org/W2075882822","https://openalex.org/W2098499925","https://openalex.org/W2099359726","https://openalex.org/W2105661064","https://openalex.org/W2107074458","https://openalex.org/W2111993374","https://openalex.org/W2113091465","https://openalex.org/W2115991524","https://openalex.org/W2118094416","https://openalex.org/W2119342165","https://openalex.org/W2121586129","https://openalex.org/W2122152313","https://openalex.org/W2130436333","https://openalex.org/W2131316809","https://openalex.org/W2143933546","https://openalex.org/W2144005980","https://openalex.org/W2153453937","https://openalex.org/W2154440790","https://openalex.org/W2157707430","https://openalex.org/W2161836519","https://openalex.org/W2163263382","https://openalex.org/W2163780760","https://openalex.org/W2165562761","https://openalex.org/W2166000052","https://openalex.org/W2168207172","https://openalex.org/W2168911650","https://openalex.org/W2171155970","https://openalex.org/W4248036824","https://openalex.org/W4252210470","https://openalex.org/W4285719527","https://openalex.org/W4301667774","https://openalex.org/W4302577372"],"related_works":["https://openalex.org/W2157707430","https://openalex.org/W2580249216","https://openalex.org/W2021476848","https://openalex.org/W2131828896","https://openalex.org/W2163704602","https://openalex.org/W1994727418","https://openalex.org/W3176234024","https://openalex.org/W2049416966","https://openalex.org/W7095787706","https://openalex.org/W2097509506"],"abstract_inverted_index":{"Treatment":[0],"of":[1,28,82,85,117,130,161,181],"infections":[2],"caused":[3,146],"by":[4,10,112,158],"Staphylococcus":[5],"aureus":[6,22],"is":[7,58],"often":[8],"confounded":[9],"the":[11,26,38,53,80,86,113,120,150,159,179,191],"bacterium's":[12],"ability":[13],"to":[14,17,46,52,75,139,143,185,190],"develop":[15],"resistance":[16,40,45,145,187],"chemotherapeutic":[18],"agents.":[19],"Methicillin-resistant":[20],"S.":[21],"(MRSA)":[23],"arises":[24],"through":[25],"acquisition":[27,64],"staphylococcal":[29],"chromosomal":[30,115],"cassette":[31],"mec":[32],"(SCCmec),":[33],"a":[34,55,62,135,147],"genomic":[35],"island":[36],"containing":[37],"methicillin":[39],"determinant,":[41],"mecA.":[42,162],"In":[43,88,163],"contrast,":[44],"vancomycin":[47,76,144,186],"can":[48],"result":[49],"from":[50],"exposure":[51],"drug,":[54],"mechanism":[56],"that":[57,72,97,103,137,153,169,178],"not":[59],"dependent":[60],"upon":[61],"gene":[63],"event.":[65],"Here":[66],"we":[67],"describe":[68],"three":[69],"MRSA":[70],"strains":[71,93,123,168],"became":[73],"resistant":[74],"during":[77,106,183],"passage":[78],"in":[79,134,149],"presence":[81],"increasing":[83],"concentrations":[84],"drug.":[87],"each":[89],"case":[90],"two":[91,122],"derivative":[92],"were":[94],"isolated,":[95],"one":[96,102],"had":[98],"lost":[99,110],"mecA":[100,105,111,171,182],"and":[101,126],"retained":[104],"passage.":[107],"Strain":[108],"5836VR":[109],"site-specific":[114],"excision":[116],"SCCmec,":[118],"while":[119],"other":[121],"(strains":[124],"3130VR":[125],"VP32)":[127],"deleted":[128],"portions":[129],"their":[131,174],"SCCmec":[132],"elements":[133],"manner":[136],"appeared":[138],"involve":[140],"IS431.":[141],"Conversion":[142],"decrease":[148],"growth":[151],"rate":[152],"was":[154,188],"partially":[155],"compensated":[156],"for":[157],"deletion":[160],"mixed-culture":[164],"competition":[165],"experiments,":[166],"vancomycin-resistant":[167],"lacked":[170],"readily":[172],"outcompeted":[173],"mecA-containing":[175],"counterparts,":[176],"suggesting":[177],"loss":[180],"conversion":[184],"advantageous":[189],"organism.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}