{"id":"https://openalex.org/W2005383004","doi":"https://doi.org/10.1016/s1388-1981(03)00062-3","title":"Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1","display_name":"Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1): a novel reaction by CYP27A1","publication_year":2003,"publication_date":"2003-05-12","ids":{"openalex":"https://openalex.org/W2005383004","doi":"https://doi.org/10.1016/s1388-1981(03)00062-3","mag":"2005383004","pmid":"https://pubmed.ncbi.nlm.nih.gov/12782149"},"language":"en","primary_location":{"id":"doi:10.1016/s1388-1981(03)00062-3","doi":"https://doi.org/10.1016/s1388-1981(03)00062-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1388-1981(03)00062-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024249460","display_name":"Zufan Araya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Zufan Araya","raw_affiliation_strings":["Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S-751 23 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S-751 23 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091190110","display_name":"Fardin Hosseinpour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fardin Hosseinpour","raw_affiliation_strings":["Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S-751 23 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S-751 23 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111532990","display_name":"Karl Bodin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karl Bodin","raw_affiliation_strings":["Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Chemistry, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047518529","display_name":"Kjell Wikvall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Kjell Wikvall","raw_affiliation_strings":["Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S-751 23 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, Husargatan 3, S-751 23 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047518529"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":0.9546,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76463567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1632","issue":"1-3","first_page":"40","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d3","display_name":"25-hydroxyvitamin D3","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cyp27a1","display_name":"CYP27A1","score":0.984000027179718},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.8939999938011169},{"id":"https://openalex.org/keywords/24-25-dihydroxyvitamin-d3","display_name":"24,25-dihydroxyvitamin D3","score":0.9750000238418579},{"id":"https://openalex.org/keywords/vitamin-d3-metabolism","display_name":"vitamin D3 metabolism","score":0.5019999742507935},{"id":"https://openalex.org/keywords/mitochondrial-cytochrome-p450","display_name":"mitochondrial cytochrome P450","score":0.8799999952316284},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.39899998903274536},{"id":"https://openalex.org/keywords/nadph-dependent-hydroxylation","display_name":"NADPH-dependent hydroxylation","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C7309524","wikidata":"https://www.wikidata.org/wiki/Q14905630","display_name":"CYP27A1","level":3,"score":0.8804458975791931},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8090307712554932},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6553418636322021},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.553671658039093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5261822938919067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5102138519287109},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5036935210227966},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4663374125957489},{"id":"https://openalex.org/C153639570","wikidata":"https://www.wikidata.org/wiki/Q906435","display_name":"Vitamin D-binding protein","level":3,"score":0.4208071529865265},{"id":"https://openalex.org/C2780106736","wikidata":"https://www.wikidata.org/wiki/Q139347","display_name":"Cholecalciferol","level":3,"score":0.4128905236721039},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.39411646127700806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35954970121383667},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25972458720207214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18937405943870544}],"mesh":[{"descriptor_ui":"D000325","descriptor_name":"Adrenodoxin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002112","descriptor_name":"Calcifediol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005287","descriptor_name":"Ferredoxin-NADP Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1388-1981(03)00062-3","doi":"https://doi.org/10.1016/s1388-1981(03)00062-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1388-1981(03)00062-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},{"id":"pmid:12782149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12782149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1482432683","https://openalex.org/W1486230207","https://openalex.org/W1548020831","https://openalex.org/W1578941266","https://openalex.org/W1752617520","https://openalex.org/W1759783632","https://openalex.org/W1968580400","https://openalex.org/W1984459074","https://openalex.org/W1999040357","https://openalex.org/W2013870444","https://openalex.org/W2018381121","https://openalex.org/W2018788952","https://openalex.org/W2019751846","https://openalex.org/W2021914078","https://openalex.org/W2041681306","https://openalex.org/W2053611923","https://openalex.org/W2058221812","https://openalex.org/W2061804779","https://openalex.org/W2066059684","https://openalex.org/W2066906905","https://openalex.org/W2071471500","https://openalex.org/W2071475076","https://openalex.org/W2073710684","https://openalex.org/W2075446617","https://openalex.org/W2077339254","https://openalex.org/W2088429050","https://openalex.org/W2099810178","https://openalex.org/W2114849059","https://openalex.org/W2257762101","https://openalex.org/W6655183970"],"related_works":["https://openalex.org/W2073710684","https://openalex.org/W2000227232","https://openalex.org/W1984459074","https://openalex.org/W2074582538","https://openalex.org/W2061108259","https://openalex.org/W2407105187","https://openalex.org/W2075446617","https://openalex.org/W2121341879","https://openalex.org/W1502347233","https://openalex.org/W3131079662"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}