{"id":"https://openalex.org/W2005381654","doi":"https://doi.org/10.1016/0278-5846(83)90040-4","title":"Involvement of biogenic amines with the mechanisms of novel analgesics","display_name":"Involvement of biogenic amines with the mechanisms of novel analgesics","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2005381654","doi":"https://doi.org/10.1016/0278-5846(83)90040-4","mag":"2005381654","pmid":"https://pubmed.ncbi.nlm.nih.gov/6141608"},"language":"en","primary_location":{"id":"doi:10.1016/0278-5846(83)90040-4","doi":"https://doi.org/10.1016/0278-5846(83)90040-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0278-5846(83)90040-4","pdf_url":null,"source":{"id":"https://openalex.org/S142279999","display_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","issn_l":"0278-5846","issn":["0278-5846","1878-4216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110106012","display_name":"Philip F. VonVoigtlander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip F. Vonvoigtlander","raw_affiliation_strings":["The UpJohn Company, Kalamazoo, Michigan 49001, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The UpJohn Company, Kalamazoo, Michigan 49001, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103430992","display_name":"Richard A. Lewis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. Lewis","raw_affiliation_strings":["The UpJohn Company, Kalamazoo, Michigan 49001, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The UpJohn Company, Kalamazoo, Michigan 49001, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045957770","display_name":"Gary L. Neff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary L. Neff","raw_affiliation_strings":["The UpJohn Company, Kalamazoo, Michigan 49001, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The UpJohn Company, Kalamazoo, Michigan 49001, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067056536","display_name":"Herman J. Triezenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herman J. Triezenberg","raw_affiliation_strings":["The UpJohn Company, Kalamazoo, Michigan 49001, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The UpJohn Company, Kalamazoo, Michigan 49001, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4380,"currency":"USD","value_usd":4380},"apc_paid":null,"fwci":2.0583,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86114576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"7","issue":"4-6","first_page":"651","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.32100000977516174,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.10119999945163727,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biogenic-amines","display_name":"biogenic amines","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/u50-488h","display_name":"U50,488H","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.7670000195503235},{"id":"https://openalex.org/keywords/p-chlorophenylalanine","display_name":"p-chlorophenylalanine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ketanserin","display_name":"ketanserin","score":0.996999979019165},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6800000071525574},{"id":"https://openalex.org/keywords/5-ht2-receptor","display_name":"5-HT2 receptor","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nefopam","display_name":"nefopam","score":0.9829999804496765},{"id":"https://openalex.org/keywords/m-tyrosine","display_name":"m-tyrosine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.6940000057220459},{"id":"https://openalex.org/keywords/non-opioid-analgesics","display_name":"non-opioid analgesics","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2777785214","wikidata":"https://www.wikidata.org/wiki/Q415997","display_name":"Ketanserin","level":5,"score":0.798819899559021},{"id":"https://openalex.org/C2777676773","wikidata":"https://www.wikidata.org/wiki/Q412226","display_name":"Yohimbine","level":4,"score":0.7631692886352539},{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.7201288342475891},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.673187255859375},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6448273062705994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5700144171714783},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.5546662211418152},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5073668360710144},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4892244338989258},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.47078317403793335},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.4569064676761627},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.3256968855857849},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3227692246437073},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2883066236972809},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2669490575790405},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2385079264640808},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.12966522574424744}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009115","descriptor_name":"Muridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009340","descriptor_name":"Nefopam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010079","descriptor_name":"Oxazocines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012684","descriptor_name":"Sensory Thresholds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017981","descriptor_name":"Receptors, Neurotransmitter","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019900","descriptor_name":"3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0278-5846(83)90040-4","doi":"https://doi.org/10.1016/0278-5846(83)90040-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0278-5846(83)90040-4","pdf_url":null,"source":{"id":"https://openalex.org/S142279999","display_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","issn_l":"0278-5846","issn":["0278-5846","1878-4216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:6141608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6141608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in neuro-psychopharmacology & biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W121026993","https://openalex.org/W1918878012","https://openalex.org/W1963809241","https://openalex.org/W1974376547","https://openalex.org/W1977294562","https://openalex.org/W1990959945","https://openalex.org/W2017294467","https://openalex.org/W2027728223","https://openalex.org/W2060957767","https://openalex.org/W2064588775","https://openalex.org/W2079028815","https://openalex.org/W2082881579","https://openalex.org/W2084101694","https://openalex.org/W2148729303","https://openalex.org/W6604908050"],"related_works":["https://openalex.org/W2098478146","https://openalex.org/W2006708464","https://openalex.org/W1851640307","https://openalex.org/W1918878012","https://openalex.org/W2023830317","https://openalex.org/W1973566592","https://openalex.org/W1999426514","https://openalex.org/W2150153964","https://openalex.org/W1990493266","https://openalex.org/W2094723953"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}