{"id":"https://openalex.org/W2005379310","doi":"https://doi.org/10.1080/01635580802381295","title":"Grape Seed Extract Induces Cell Cycle Arrest and Apoptosis in Human Colon Carcinoma Cells","display_name":"Grape Seed Extract Induces Cell Cycle Arrest and Apoptosis in Human Colon Carcinoma Cells","publication_year":2008,"publication_date":"2008-11-10","ids":{"openalex":"https://openalex.org/W2005379310","doi":"https://doi.org/10.1080/01635580802381295","mag":"2005379310","pmid":"https://pubmed.ncbi.nlm.nih.gov/19003575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2597484"},"language":"en","primary_location":{"id":"doi:10.1080/01635580802381295","doi":"https://doi.org/10.1080/01635580802381295","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01635580802381295","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2597484","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006344919","display_name":"Manjinder Kaur","orcid":"https://orcid.org/0000-0002-3412-0276","observed_orcids":["https://orcid.org/0000-0002-3412-0276"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manjinder Kaur","raw_affiliation_strings":["University of Colorado Denver","University of Colorado Denver , Denver, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado Denver , Denver, Colorado, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042874694","display_name":"Reinuka Mandair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinuka Mandair","raw_affiliation_strings":["University of Colorado Denver","University of Colorado Denver , Denver, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado Denver , Denver, Colorado, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048444823","display_name":"Rajesh Agarwal","orcid":"https://orcid.org/0000-0002-9455-0235","observed_orcids":["https://orcid.org/0000-0002-9455-0235"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Agarwal","raw_affiliation_strings":["University of Colorado Denver","University of Colorado Denver , Denver, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado Denver , Denver, Colorado, USA","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027734680","display_name":"Chapla Agarwal","orcid":"https://orcid.org/0000-0003-1146-4890","observed_orcids":["https://orcid.org/0000-0003-1146-4890"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chapla Agarwal","raw_affiliation_strings":["University of Colorado Denver","University of Colorado Denver , Denver, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Denver","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado Denver , Denver, Colorado, USA","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":4.3961,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.94194997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"60","issue":"sup1","first_page":"2","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grape-seed-extract","display_name":"grape seed extract","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.8989999890327454},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"complementary and alternative medicine","score":0.984000027179718},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lovo-cells","display_name":"LoVo cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/sw480-cells","display_name":"SW480 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vendor-comparison","display_name":"manufacturer comparison","score":0.4699999988079071},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2776971262","wikidata":"https://www.wikidata.org/wiki/Q5597007","display_name":"Grape seed extract","level":3,"score":0.8716124296188354},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7929157018661499},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.720309853553772},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6139340996742249},{"id":"https://openalex.org/C3019171606","wikidata":"https://www.wikidata.org/wiki/Q10978","display_name":"Grape seed","level":2,"score":0.5532009601593018},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5503321886062622},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.547362208366394},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5403658747673035},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5162622928619385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5016405582427979},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42302921414375305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36226874589920044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3330056667327881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32960599660873413},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3288758397102356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22658321261405945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2201395034790039},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.14580503106117249},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10170063376426697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0700138509273529},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/01635580802381295","doi":"https://doi.org/10.1080/01635580802381295","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01635580802381295","pdf_url":null,"source":{"id":"https://openalex.org/S105083709","display_name":"Nutrition and Cancer","issn_l":"0163-5581","issn":["0163-5581","1532-7914"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319847","host_organization_name":"Routledge","host_organization_lineage":["https://openalex.org/P4310319847","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Routledge","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and Cancer","raw_type":"journal-article"},{"id":"pmid:19003575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19003575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2597484","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2597484","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nutr Cancer","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2597484","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2597484","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nutr Cancer","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3003866528","display_name":null,"funder_award_id":"R01 AT-003623","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G6778190871","display_name":"Colon Cancer Chemoprevention by Grape Seed Extract","funder_award_id":"5r01at003623-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320329640","display_name":"Independent University, Bangladesh","ror":"https://ror.org/05qbbf772"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333552","display_name":"Cancer Center, University of Colorado","ror":"https://ror.org/04cqn7d42"},{"id":"https://openalex.org/F4320337358","display_name":"National Center for Complementary and Alternative Medicine","ror":"https://ror.org/00190t495"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W56616137","https://openalex.org/W80851243","https://openalex.org/W152888713","https://openalex.org/W1487531210","https://openalex.org/W1569214109","https://openalex.org/W1638902273","https://openalex.org/W1919724288","https://openalex.org/W1975582550","https://openalex.org/W1977668530","https://openalex.org/W1979319210","https://openalex.org/W1980282332","https://openalex.org/W1985058212","https://openalex.org/W1988294212","https://openalex.org/W1992028595","https://openalex.org/W1995454965","https://openalex.org/W2000061441","https://openalex.org/W2002797577","https://openalex.org/W2017288116","https://openalex.org/W2021505095","https://openalex.org/W2026004604","https://openalex.org/W2030067183","https://openalex.org/W2031682879","https://openalex.org/W2043011598","https://openalex.org/W2047492665","https://openalex.org/W2051357113","https://openalex.org/W2073168217","https://openalex.org/W2086969239","https://openalex.org/W2090894363","https://openalex.org/W2096639977","https://openalex.org/W2104366204","https://openalex.org/W2111649506","https://openalex.org/W2111714921","https://openalex.org/W2119979638","https://openalex.org/W2121619780","https://openalex.org/W2122438523","https://openalex.org/W2125988618","https://openalex.org/W2138448256","https://openalex.org/W2138846137","https://openalex.org/W2139050844","https://openalex.org/W2142538286","https://openalex.org/W2150896970","https://openalex.org/W2166511953","https://openalex.org/W2171018696","https://openalex.org/W2271369716","https://openalex.org/W2337344701"],"related_works":["https://openalex.org/W2096639977","https://openalex.org/W2333026897","https://openalex.org/W2000622610","https://openalex.org/W72149043","https://openalex.org/W2070277360","https://openalex.org/W1991791423","https://openalex.org/W2155281823","https://openalex.org/W2317963773","https://openalex.org/W2076853166","https://openalex.org/W1574529330"],"abstract_inverted_index":{"One":[0],"approach":[1],"to":[2,48,190],"control":[3],"colorectal":[4],"cancer":[5],"(CRC)":[6],"is":[7,55,86],"its":[8,64,191],"preventive":[9],"intervention":[10],"by":[11,28,61,171],"dietary":[12],"agents":[13],"or":[14],"those":[15],"consumed":[16,27,60],"as":[17,30,41],"supplements.":[18],"However,":[19],"because":[20],"most":[21],"of":[22,108,118,162],"these":[23],"products":[24],"are":[25],"often":[26],"patients":[29],"an":[31,139,160,182],"complementary":[32],"and":[33,44,80,125,135,195],"alternative":[34],"medicine":[35],"practice,":[36],"a":[37,106,130],"scientific":[38],"base":[39],"such":[40,57],"efficacy,":[42],"mechanism,":[43],"standardized":[45],"preparation":[46],"needs":[47],"be":[49,181],"developed.":[50],"Grape":[51],"seed":[52],"extract":[53],"(GSE)":[54],"one":[56],"supplement":[58],"widely":[59],"humans":[62],"for":[63],"several":[65],"health":[66],"benefits.":[67],"We":[68],"reported":[69],"recently":[70],"that":[71,116,178],"GSE":[72,85,96,120,149,179],"inhibits":[73,122],"CRC":[74,110,187],"cell":[75,111,127,146,157,169],"HT29":[76,136],"growth":[77,193],"in":[78,105,133,144,154,166],"culture":[79],"nude":[81],"mice":[82],"xenograft.":[83],"Because":[84],"available":[87],"commercially":[88],"through":[89],"different":[90,99],"vendors,":[91],"here":[92],"we":[93],"assessed":[94],"whether":[95],"from":[97],"2":[98],"manufacturers":[100],"produces":[101],"comparable":[102],"biological":[103],"effects":[104],"panel":[107],"human":[109],"lines.":[112,158],"Our":[113],"results":[114],"show":[115],"irrespective":[117],"source,":[119],"strongly":[121],"LoVo,":[123],"HT29,":[124],"SW480":[126,145],"growth,":[128],"with":[129],"G1":[131],"arrest":[132,143],"LoVo":[134],"cells":[137],"but":[138],"S":[140],"and/or":[141],"G2/M":[142],"cycle":[147],"progression.":[148],"also":[150],"induced":[151],"Cip/p21":[152],"levels":[153],"all":[155,167],"3":[156,168],"Furthermore,":[159],"induction":[161],"apoptosis":[163],"was":[164],"observed":[165],"lines":[170],"GSE.":[172],"Taken":[173],"together,":[174],"our":[175],"findings":[176],"suggest":[177],"could":[180],"effective":[183],"CAM":[184],"agent":[185],"against":[186],"possibly":[188],"due":[189],"strong":[192],"inhibitory":[194],"apoptosis-inducing":[196],"effects.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
