{"id":"https://openalex.org/W2005379110","doi":"https://doi.org/10.1002/btpr.602","title":"Kinetic characterization of the group II helicoverpa armigera nucleopolyhedrovirus propagated in suspension cell cultures: Implications for development of a biopesticides production process","display_name":"Kinetic characterization of the group II helicoverpa armigera nucleopolyhedrovirus propagated in suspension cell cultures: Implications for development of a biopesticides production process","publication_year":2011,"publication_date":"2011-03-23","ids":{"openalex":"https://openalex.org/W2005379110","doi":"https://doi.org/10.1002/btpr.602","mag":"2005379110","pmid":"https://pubmed.ncbi.nlm.nih.gov/21644255"},"language":"en","primary_location":{"id":"doi:10.1002/btpr.602","doi":"https://doi.org/10.1002/btpr.602","is_oa":false,"landing_page_url":"https://doi.org/10.1002/btpr.602","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040886251","display_name":"M\u00e1rcia Regina da Silva Pedrini","orcid":"https://orcid.org/0000-0001-6697-5036","observed_orcids":["https://orcid.org/0000-0001-6697-5036"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcia R. S. Pedrini","raw_affiliation_strings":["N\u00facleo Tecnol\u00f3gico, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Engenharia Qu\u00edmica, Universidade Federal do Rio Grande do Norte, Campus Universit\u00e1rio, Lagoa Nova, Cep 59072-970, Natal, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N\u00facleo Tecnol\u00f3gico, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Engenharia Qu\u00edmica, Universidade Federal do Rio Grande do Norte, Campus Universit\u00e1rio, Lagoa Nova, Cep 59072-970, Natal, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045470419","display_name":"Steven Reid","orcid":"https://orcid.org/0000-0002-6103-3354","observed_orcids":["https://orcid.org/0000-0002-6103-3354"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Steven Reid","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061172047","display_name":"Lars Keld Nielsen","orcid":"https://orcid.org/0000-0001-8191-3511","observed_orcids":["https://orcid.org/0000-0001-8191-3511","https://orcid.org/0000-0001-9537-0335"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lars K. Nielsen","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110003301","display_name":"Leslie C. L. Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Leslie C. L. Chan","raw_affiliation_strings":["Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110003301"],"corresponding_institution_ids":["https://openalex.org/I165143802"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":1.0378,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.73859724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"3","first_page":"614","last_page":"624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11436","display_name":"Entomopathogenic Microorganisms in Pest Control","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicoverpa-armigera-nucleopolyhedrovirus","display_name":"Helicoverpa armigera nucleopolyhedrovirus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-suspension-culture","display_name":"cell suspension culture","score":0.6589999794960022},{"id":"https://openalex.org/keywords/biopesticide-production","display_name":"biopesticide production","score":0.878000020980835},{"id":"https://openalex.org/keywords/binding-rate","display_name":"binding rate","score":0.9240000247955322},{"id":"https://openalex.org/keywords/autographa-californica-multiple-nucleopolyhedrovirus","display_name":"Autographa californica nuclear polyhedrosis virus","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C120835403","wikidata":"https://www.wikidata.org/wiki/Q987575","display_name":"Biopesticide","level":3,"score":0.8628402948379517},{"id":"https://openalex.org/C2780199244","wikidata":"https://www.wikidata.org/wiki/Q4826309","display_name":"Autographa californica","level":5,"score":0.726718544960022},{"id":"https://openalex.org/C2776712339","wikidata":"https://www.wikidata.org/wiki/Q811652","display_name":"Helicoverpa armigera","level":3,"score":0.7086634635925293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7027872800827026},{"id":"https://openalex.org/C2777212814","wikidata":"https://www.wikidata.org/wiki/Q763221","display_name":"Baculoviridae","level":5,"score":0.5953884720802307},{"id":"https://openalex.org/C2778551188","wikidata":"https://www.wikidata.org/wiki/Q2235268","display_name":"Helicoverpa","level":4,"score":0.5330119729042053},{"id":"https://openalex.org/C198410946","wikidata":"https://www.wikidata.org/wiki/Q845312","display_name":"Budding","level":2,"score":0.47681018710136414},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4644496440887451},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42442595958709717},{"id":"https://openalex.org/C177756618","wikidata":"https://www.wikidata.org/wiki/Q6527674","display_name":"Lepidoptera genitalia","level":2,"score":0.35622531175613403},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3371617794036865},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.2297574281692505},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.21822798252105713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16840142011642456},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.10881879925727844},{"id":"https://openalex.org/C2777773057","wikidata":"https://www.wikidata.org/wiki/Q2492887","display_name":"Spodoptera","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004266","descriptor_name":"DNA Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007304","descriptor_name":"Insect Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007313","descriptor_name":"Insecta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007313","descriptor_name":"Insecta","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010572","descriptor_name":"Pest Control, Biological","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D014776","descriptor_name":"Virus Cultivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017924","descriptor_name":"Nucleopolyhedroviruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017924","descriptor_name":"Nucleopolyhedroviruses","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017924","descriptor_name":"Nucleopolyhedroviruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/btpr.602","doi":"https://doi.org/10.1002/btpr.602","is_oa":false,"landing_page_url":"https://doi.org/10.1002/btpr.602","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},{"id":"pmid:21644255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21644255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology progress","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.6735000014305115,"display_name":"Zero hunger"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W256980506","https://openalex.org/W437229422","https://openalex.org/W1585330735","https://openalex.org/W1861740404","https://openalex.org/W1897069665","https://openalex.org/W1971786479","https://openalex.org/W1976341978","https://openalex.org/W1982225977","https://openalex.org/W1984406334","https://openalex.org/W1986154134","https://openalex.org/W1990537991","https://openalex.org/W1998537145","https://openalex.org/W1999150301","https://openalex.org/W2001155691","https://openalex.org/W2001805029","https://openalex.org/W2011034048","https://openalex.org/W2011284066","https://openalex.org/W2023908850","https://openalex.org/W2028706407","https://openalex.org/W2031910333","https://openalex.org/W2034417219","https://openalex.org/W2038493876","https://openalex.org/W2048588124","https://openalex.org/W2050717010","https://openalex.org/W2057909529","https://openalex.org/W2063460869","https://openalex.org/W2068175060","https://openalex.org/W2070879001","https://openalex.org/W2073545911","https://openalex.org/W2075800302","https://openalex.org/W2085352587","https://openalex.org/W2087308055","https://openalex.org/W2087944963","https://openalex.org/W2089536471","https://openalex.org/W2089772918","https://openalex.org/W2093433620","https://openalex.org/W2101632670","https://openalex.org/W2107661572","https://openalex.org/W2114800997","https://openalex.org/W2116005117","https://openalex.org/W2116480459","https://openalex.org/W2118832701","https://openalex.org/W2119909782","https://openalex.org/W2127865821","https://openalex.org/W2131335594","https://openalex.org/W2135634224","https://openalex.org/W2135682000","https://openalex.org/W2137537220","https://openalex.org/W2140836172","https://openalex.org/W2146213942","https://openalex.org/W2149229942","https://openalex.org/W2170641144","https://openalex.org/W2175553381","https://openalex.org/W2175802407","https://openalex.org/W2200288427","https://openalex.org/W2202085416","https://openalex.org/W2293375660","https://openalex.org/W2415804527"],"related_works":["https://openalex.org/W2068313956","https://openalex.org/W2068175060","https://openalex.org/W1533884815","https://openalex.org/W108329662","https://openalex.org/W2048513967","https://openalex.org/W2086709617","https://openalex.org/W4393969785","https://openalex.org/W2092481780","https://openalex.org/W2197333297","https://openalex.org/W1974188063"],"abstract_inverted_index":{"Large-scale":[0],"commercialization":[1],"of":[2,8,19,59,91,177,189,195,211,227,231],"baculovirus":[3],"biopesticides":[4],"for":[5,27,39,77,186,244],"the":[6,20,40,60,78,89,109,184,193,220,224,237],"control":[7],"insect":[9,84],"pests":[10],"requires":[11],"a":[12,24,48,99,118,124,153,161,241],"cell":[13,85,106],"culture":[14],"production":[15,181],"process,":[16,182],"and":[17,68,108,160,192,201,236],"knowledge":[18],"infection":[21,56,142,170,208,234],"kinetics":[22,143,171,209],"is":[23,219],"vital":[25],"prerequisite":[26],"process":[28],"optimization.":[29],"Well-characterized":[30],"kinetic":[31,57,110,245],"parameters":[32,58],"have":[33,172,205],"so":[34],"far":[35],"only":[36],"been":[37],"reported":[38],"commercially":[41],"established":[42],"recombinant":[43],"Autographa":[44],"californica":[45],"nucleopolyhedrovirus":[46,66],"(AcMNPV),":[47],"Group":[49,61],"I":[50,200],"NPV.":[51],"In":[52],"this":[53,114],"work,":[54],"key":[55],"II":[62,202],"NPV":[63],"Helicoverpa":[64],"armigera":[65],"(HaSNPV),":[67],"its":[69],"Few":[70],"Polyhedra":[71],"(FP)":[72],"mutant,":[73],"were":[74],"well":[75],"characterized":[76],"first":[79,221],"time,":[80],"in":[81,105,229],"suspension":[82],"HzAM1":[83],"cultures,":[86,107],"to":[87,117,222],"facilitate":[88],"scale-up":[90,176],"an":[92,149,178],"HaSNPV-based":[93],"biopesticide.":[94],"The":[95],"FP":[96],"mutant":[97],"had":[98,139],"selective":[100],"advantage":[101],"over":[102],"wild-type":[103,137],"HaSNPV":[104,138,179],"analysis":[111],"showed":[112],"that":[113,136],"was":[115,135],"due":[116],"superior":[119],"budding":[120,131,158],"rate,":[121,159],"rather":[122],"than":[123,155],"faster":[125],"binding":[126],"rate":[127],"(BR)":[128],"or":[129],"longer":[130],"duration.":[132],"Another":[133],"finding":[134],"very":[140,206],"poor":[141,169],"when":[144],"compared":[145],"with":[146],"AcMNPV,":[147],"exhibiting":[148],"18-fold":[150],"lower":[151,157,163],"BR,":[152],"more":[154],"50-fold":[156],"60-fold":[162],"extracellular/total":[164],"progeny":[165],"virus":[166,190],"ratio.":[167],"Such":[168],"serious":[173],"implications":[174],"during":[175],"biopesticide":[180],"including":[183],"requirement":[185],"large":[187],"volumes":[188],"inocula":[191],"difficulty":[194],"achieving":[196],"synchronous":[197],"infections.":[198],"Groups":[199],"NPVs":[203,228],"may":[204,239],"different":[207,213],"because":[210],"their":[212],"envelope":[214],"fusion":[215],"proteins.":[216],"This":[217],"study":[218],"compare":[223],"two":[225],"groups":[226],"terms":[230],"well-characterized":[232],"cell-specific":[233],"kinetics,":[235],"findings":[238],"indicate":[240],"phylogenetic":[242],"basis":[243],"differences.":[246]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
