{"id":"https://openalex.org/W2005376709","doi":"https://doi.org/10.1016/j.amjoto.2010.02.003","title":"Protective effects of Salvia miltiorrhiza against cisplatin-induced ototoxicity in guinea pigs","display_name":"Protective effects of Salvia miltiorrhiza against cisplatin-induced ototoxicity in guinea pigs","publication_year":2010,"publication_date":"2010-05-07","ids":{"openalex":"https://openalex.org/W2005376709","doi":"https://doi.org/10.1016/j.amjoto.2010.02.003","mag":"2005376709","pmid":"https://pubmed.ncbi.nlm.nih.gov/20447728"},"language":"en","primary_location":{"id":"doi:10.1016/j.amjoto.2010.02.003","doi":"https://doi.org/10.1016/j.amjoto.2010.02.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjoto.2010.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S204216521","display_name":"American Journal of Otolaryngology","issn_l":"0196-0709","issn":["0196-0709","1532-818X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Otolaryngology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005376709"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103143319","display_name":"Ou Xu","orcid":"https://orcid.org/0000-0002-6039-7877","observed_orcids":["https://orcid.org/0000-0002-6039-7877"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ou Xu","raw_affiliation_strings":["Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035439397","display_name":"Yanxing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxing Liu","raw_affiliation_strings":["Department of Pharmacology, Hebei Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Hebei Medical University, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452121","display_name":"Xiaoming Li","orcid":"https://orcid.org/0000-0002-0931-727X","observed_orcids":["https://orcid.org/0000-0002-0931-727X"]},"institutions":[{"id":"https://openalex.org/I4210132332","display_name":"Bethune International Peace Hospital","ror":"https://ror.org/040aks519","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132332"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoming Li","raw_affiliation_strings":["Department of Otorhinolaryngology, Bethune International Peace Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Bethune International Peace Hospital, China","institution_ids":["https://openalex.org/I4210132332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101564351","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0002-8169-7422","observed_orcids":["https://orcid.org/0000-0002-8169-7422","https://orcid.org/0000-0002-0692-8024","https://orcid.org/0000-0001-7447-4119"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yang","raw_affiliation_strings":["Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069329386","display_name":"Zaixing Zhang","orcid":"https://orcid.org/0000-0001-5426-3613","observed_orcids":["https://orcid.org/0000-0001-5426-3613"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zaixing Zhang","raw_affiliation_strings":["Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461406","display_name":"Na Wang","orcid":"https://orcid.org/0000-0002-5806-4379","observed_orcids":["https://orcid.org/0000-0002-5806-4379"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Wang","raw_affiliation_strings":["Department of Pharmacology, Hebei Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Hebei Medical University, China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878354","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0003-4521-7994","observed_orcids":["https://orcid.org/0000-0003-4521-7994"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210099373"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hong Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]},{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong Lu","raw_affiliation_strings":["Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, The 2nd Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, China","institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210099373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111381250","https://openalex.org/I4210099373"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":0.6862,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.64639385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"32","issue":"3","first_page":"228","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cochlear-damage","display_name":"cochlear damage","score":0.6610000133514404},{"id":"https://openalex.org/keywords/auditory-brainstem-response","display_name":"auditory brainstem response","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cochlear-blood-flow","display_name":"cochlear blood flow","score":0.7590000033378601},{"id":"https://openalex.org/keywords/stria-vascularis","display_name":"stria vascularis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/spiral-ganglion-neurons","display_name":"spiral ganglion neurons","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hair-cell-loss","display_name":"hair cell loss","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6679999828338623},{"id":"https://openalex.org/keywords/drug-induced-hearing-loss","display_name":"drug-induced hearing loss","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9566282033920288},{"id":"https://openalex.org/C2776332195","wikidata":"https://www.wikidata.org/wiki/Q1000854","display_name":"Salvia miltiorrhiza","level":4,"score":0.9391440153121948},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.9046615362167358},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6872057914733887},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5976034998893738},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5160467028617859},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5121955275535583},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.4145069718360901},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2073020040988922},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19448554515838623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19030794501304626},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.14391687512397766},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09704375267028809},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011322","descriptor_name":"Primary Prevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013136","descriptor_name":"Spiral Ganglion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013136","descriptor_name":"Spiral Ganglion","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D027561","descriptor_name":"Salvia miltiorrhiza","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.amjoto.2010.02.003","doi":"https://doi.org/10.1016/j.amjoto.2010.02.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjoto.2010.02.003","pdf_url":null,"source":{"id":"https://openalex.org/S204216521","display_name":"American Journal of Otolaryngology","issn_l":"0196-0709","issn":["0196-0709","1532-818X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Otolaryngology","raw_type":"journal-article"},{"id":"pmid:20447728","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20447728","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of otolaryngology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W86004046","https://openalex.org/W299699636","https://openalex.org/W1973677547","https://openalex.org/W1974768240","https://openalex.org/W1996202908","https://openalex.org/W2025940858","https://openalex.org/W2028339911","https://openalex.org/W2043167396","https://openalex.org/W2051610540","https://openalex.org/W2073260790","https://openalex.org/W2085859342","https://openalex.org/W2088437631","https://openalex.org/W2113999599","https://openalex.org/W2124161324","https://openalex.org/W2347498752","https://openalex.org/W2365162506"],"related_works":["https://openalex.org/W2347485113","https://openalex.org/W2380751383","https://openalex.org/W2386957201","https://openalex.org/W2359332199","https://openalex.org/W2052832954","https://openalex.org/W2380285775","https://openalex.org/W2095382445","https://openalex.org/W2182111396","https://openalex.org/W4235745092","https://openalex.org/W2386222547"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}