{"id":"https://openalex.org/W2005367935","doi":"https://doi.org/10.1046/j.1524-475x.2003.11407.x","title":"Development of a reconstructed human skin model for angiogenesis","display_name":"Development of a reconstructed human skin model for angiogenesis","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2005367935","doi":"https://doi.org/10.1046/j.1524-475x.2003.11407.x","mag":"2005367935","pmid":"https://pubmed.ncbi.nlm.nih.gov/12846915"},"language":"en","primary_location":{"id":"doi:10.1046/j.1524-475x.2003.11407.x","doi":"https://doi.org/10.1046/j.1524-475x.2003.11407.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1524-475x.2003.11407.x","pdf_url":null,"source":{"id":"https://openalex.org/S121715350","display_name":"Wound Repair and Regeneration","issn_l":"1067-1927","issn":["1067-1927","1524-475X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Repair and Regeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068480092","display_name":"Parbinder S. Sahota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Parbinder S. Sahota","raw_affiliation_strings":["Section of Human Metabolism, Division of Clinical Sciences (North), Northern General Hospital, Sheffield, United Kingdom. P.S.Sahota@sheffield.ac.uk","From the Section of Human Metabolisma,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Human Metabolism, Division of Clinical Sciences (North), Northern General Hospital, Sheffield, United Kingdom. P.S.Sahota@sheffield.ac.uk","institution_ids":["https://openalex.org/I2801759359"]},{"raw_affiliation_string":"From the Section of Human Metabolisma,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108420361","display_name":"J. Lance Burn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Lance Burn","raw_affiliation_strings":["Division of Clinical Sciences (North), Northern General Hospital, Section of Surgical and Anesthetic Sciencesb,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Sciences (North), Northern General Hospital, Section of Surgical and Anesthetic Sciencesb,","institution_ids":["https://openalex.org/I2801759359"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024241236","display_name":"Martin J. Heaton","orcid":"https://orcid.org/0000-0001-6760-2952","observed_orcids":["https://orcid.org/0000-0001-6760-2952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Heaton","raw_affiliation_strings":["From the Section of Human Metabolisma,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Human Metabolisma,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006249778","display_name":"Eric Freedlander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eric Freedlander","raw_affiliation_strings":["Division of Clinical Sciences (South), Royal Hallamshire Hospital, Department of Reconstructive Plastic Surgery and Burnsc and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Sciences (South), Royal Hallamshire Hospital, Department of Reconstructive Plastic Surgery and Burnsc and","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114044151","display_name":"Simon Kim Suvarna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon K. Suvarna","raw_affiliation_strings":["Histopathologyd,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histopathologyd,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016753393","display_name":"Nicola Jane Brown","orcid":"https://orcid.org/0000-0002-2100-1905","observed_orcids":["https://orcid.org/0000-0002-2100-1905"]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola J. Brown","raw_affiliation_strings":["Division of Clinical Sciences (North), Northern General Hospital, Section of Surgical and Anesthetic Sciencesb,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Sciences (North), Northern General Hospital, Section of Surgical and Anesthetic Sciencesb,","institution_ids":["https://openalex.org/I2801759359"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028170694","display_name":"Shelia Mac Neil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801759359","display_name":"Northern General Hospital","ror":"https://ror.org/05r409z22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801759359","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shelia Mac Neil","raw_affiliation_strings":["From the Section of Human Metabolisma,","Northern General Hospital, and Department of Engineering Materialse, Sir Robert Hadfield Building, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Human Metabolisma,","institution_ids":[]},{"raw_affiliation_string":"Northern General Hospital, and Department of Engineering Materialse, Sir Robert Hadfield Building, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I2801759359"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":5.1236,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.94547179,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"275","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.10769999772310257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reconstructed-human-skin","display_name":"reconstructed human skin","score":0.7279999852180481},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dermal-microvascular-endothelial-cells","display_name":"dermal microvascular endothelial cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/autologous-keratinocytes","display_name":"autologous keratinocytes","score":0.7839999794960022},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9330000281333923},{"id":"https://openalex.org/keywords/endothelial-cell-culture","display_name":"endothelial cell culture","score":0.6880000233650208},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8064645528793335},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.6503848433494568},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6340612769126892},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6131913065910339},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5727302432060242},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5380072593688965},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4844415485858917},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4362049996852875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41265544295310974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35551002621650696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34738120436668396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32833170890808105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3256374001502991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29927974939346313},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21100181341171265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1524-475x.2003.11407.x","doi":"https://doi.org/10.1046/j.1524-475x.2003.11407.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1524-475x.2003.11407.x","pdf_url":null,"source":{"id":"https://openalex.org/S121715350","display_name":"Wound Repair and Regeneration","issn_l":"1067-1927","issn":["1067-1927","1524-475X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Repair and Regeneration","raw_type":"journal-article"},{"id":"pmid:12846915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12846915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320014","display_name":"Royal College of Surgeons of England","ror":"https://ror.org/02qrg5a24"},{"id":"https://openalex.org/F4320323347","display_name":"Healing Foundation","ror":"https://ror.org/041kwj007"},{"id":"https://openalex.org/F4320332554","display_name":"School of Medicine, Emory University","ror":"https://ror.org/03czfpz43"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W269786249","https://openalex.org/W1723227640","https://openalex.org/W1995379887","https://openalex.org/W1997509414","https://openalex.org/W2006354469","https://openalex.org/W2010067741","https://openalex.org/W2012526429","https://openalex.org/W2013396957","https://openalex.org/W2028143686","https://openalex.org/W2029446127","https://openalex.org/W2031274296","https://openalex.org/W2032738485","https://openalex.org/W2034825883","https://openalex.org/W2037474992","https://openalex.org/W2045934824","https://openalex.org/W2049043712","https://openalex.org/W2055887720","https://openalex.org/W2061838858","https://openalex.org/W2066283662","https://openalex.org/W2087650119","https://openalex.org/W2089671691","https://openalex.org/W2127827743","https://openalex.org/W2135054721","https://openalex.org/W2159317177","https://openalex.org/W2405283549","https://openalex.org/W2990053032","https://openalex.org/W4252797238"],"related_works":["https://openalex.org/W2028283357","https://openalex.org/W1723227640","https://openalex.org/W179243034","https://openalex.org/W4309472778","https://openalex.org/W2141642398","https://openalex.org/W4409335111","https://openalex.org/W4415542491","https://openalex.org/W1650154665","https://openalex.org/W2084477726","https://openalex.org/W4401100615"],"abstract_inverted_index":{"We":[0,87],"have":[1],"previously":[2],"shown":[3],"that":[4,89,147],"reconstructed":[5,33,54,70,191],"human":[6,93],"skin":[7,34,55,71,130,145,192],"engineered":[8],"from":[9,127],"autologous":[10,194],"keratinocytes,":[11,195],"fibroblasts,":[12,121,196],"and":[13,84,122,136,181,197],"sterilized":[14],"donor":[15],"allodermis":[16],"stimulates":[17],"angiogenesis":[18,80,178],"within":[19],"5-7":[20],"days":[21],"when":[22],"placed":[23],"on":[24],"well-vascularized":[25],"wound":[26,41],"beds":[27],"in":[28,38,62,73,82,85,161,171,179],"nude":[29],"mice.":[30],"When":[31],"this":[32,53,63,165],"was":[35,65,99],"used":[36],"clinically":[37],"more":[39],"demanding":[40],"beds,":[42],"some":[43],"grafts":[44],"were":[45,150],"lost,":[46],"possibly":[47],"due":[48],"to":[49,66,75,78,108,173],"delayed":[50],"vascularization.":[51],"As":[52],"lacks":[56],"any":[57],"endothelial":[58,96,140,198],"cells,":[59],"our":[60],"aim":[61],"study":[64],"develop":[67],"an":[68,106],"angiogenic":[69],"model":[72,170],"which":[74,172],"explore":[76,174],"strategies":[77,175],"improve":[79],"both":[81],"vitro":[83,180],"vivo.":[86],"report":[88],"culture":[90,159,185],"of":[91,116,139,152,190],"small-vessel":[92],"dermal":[94],"microvascular":[95],"cells":[97,141,149],"(HuDMECs)":[98],"achieved":[100],"using":[101],"magnetic":[102],"beads":[103],"coated":[104],"with":[105,142,168],"antibody":[107],"platelet":[109],"cell":[110],"adhesion":[111],"molecule":[112],"as":[113],"a":[114,169],"means":[115],"purifying":[117],"the":[118,128,143,155,184,188],"culture.":[119],"Keratinocytes,":[120],"HuDMECs":[123,135],"could":[124],"be":[125],"cultured":[126],"same":[129],"biopsy.":[131],"Initial":[132],"studies":[133],"culturing":[134],"other":[137],"sources":[138],"tissue-engineered":[144],"showed":[146],"these":[148],"capable":[151],"slowly":[153],"entering":[154],"dermis":[156],"under":[157],"standard":[158],"conditions":[160],"vitro.":[162],"In":[163],"conclusion,":[164],"provides":[166],"us":[167],"for":[176,187],"improving":[177],"also":[182],"establishes":[183],"methodologies":[186],"production":[189],"containing":[193],"cells.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}