{"id":"https://openalex.org/W2005367927","doi":"https://doi.org/10.1089/088922299309801","title":"Effect of Long-Term Infection with nef-Defective Attenuated HIV Type 1 on CD4+ and CD8+ T Lymphocytes: Increased CD45RO+ CD4+ T Lymphocytes and Limited Activation of CD8+ T Lymphocytes","display_name":"Effect of Long-Term Infection with nef-Defective Attenuated HIV Type 1 on CD4+ and CD8+ T Lymphocytes: Increased CD45RO+ CD4+ T Lymphocytes and Limited Activation of CD8+ T Lymphocytes","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2005367927","doi":"https://doi.org/10.1089/088922299309801","mag":"2005367927","pmid":"https://pubmed.ncbi.nlm.nih.gov/10580402"},"language":"en","primary_location":{"id":"doi:10.1089/088922299309801","doi":"https://doi.org/10.1089/088922299309801","is_oa":false,"landing_page_url":"https://doi.org/10.1089/088922299309801","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088309165","display_name":"John James Zaunders","orcid":"https://orcid.org/0000-0002-5912-5989","observed_orcids":["https://orcid.org/0000-0002-5912-5989"]},"institutions":[{"id":"https://openalex.org/I4210087284","display_name":"St Vincent's Hospital Sydney","ror":"https://ror.org/000ed3w25","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087284"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John J. Zaunders","raw_affiliation_strings":["Centre for Immunology, St. Vincent's Hospital, Darlinghurst, NSW, Australia. j.zaunders@cfi.unsw.edu.au","Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Immunology, St. Vincent's Hospital, Darlinghurst, NSW, Australia. j.zaunders@cfi.unsw.edu.au","institution_ids":["https://openalex.org/I4210087284"]},{"raw_affiliation_string":"Centre for Immunology, St Vincent's Hospital, Darlinghurst, NSW, Australia","institution_ids":["https://openalex.org/I4210087284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113647139","display_name":"Andrew F. Geczy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew F. Geczy","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091403155","display_name":"Wayne B. Dyer","orcid":"https://orcid.org/0000-0003-3193-2559","observed_orcids":["https://orcid.org/0000-0003-3193-2559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne B. Dyer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005455736","display_name":"Larissa B. McIntyre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa B. McIntyre","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103469741","display_name":"Margaret A. Cooley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret A. Cooley","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111974201","display_name":"Lesley J. Ashton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lesley J. Ashton","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045457076","display_name":"Camille H. Raynes\u2010Greenow","orcid":"https://orcid.org/0000-0002-8802-6226","observed_orcids":["https://orcid.org/0000-0002-8802-6226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camille H. Raynes-Greenow","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039043995","display_name":"Jenny Learmont","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenny Learmont","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834622","display_name":"David A. Cooper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Cooper","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103509409","display_name":"John S. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. Sullivan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6194,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.62190923,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"15","issue":"17","first_page":"1519","last_page":"1527"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6480000019073486},{"id":"https://openalex.org/keywords/long-term-infection","display_name":"long-term infection","score":0.628000020980835},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cd45ro-t-cells","display_name":"CD45RO+ memory T cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.7239999771118164},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.847000002861023},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.546999990940094},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cytopathic-effect","display_name":"cytopathic effect","score":0.7480000257492065},{"id":"https://openalex.org/keywords/long-term-nonprogressors","display_name":"long-term nonprogressors","score":0.6840000152587891},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.7107643485069275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6293838024139404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6067501306533813},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.5952733755111694},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.512997567653656},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.4998924732208252},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4447404742240906},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.42038673162460327},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3323679566383362},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1583380103111267},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003673","descriptor_name":"Defective Viruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015754","descriptor_name":"Genes, nef","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016516","descriptor_name":"CD4-CD8 Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/088922299309801","doi":"https://doi.org/10.1089/088922299309801","is_oa":false,"landing_page_url":"https://doi.org/10.1089/088922299309801","pdf_url":null,"source":{"id":"https://openalex.org/S161282271","display_name":"AIDS Research and Human Retroviruses","issn_l":"0889-2229","issn":["0889-2229","1931-8405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS Research and Human Retroviruses","raw_type":"journal-article"},{"id":"pmid:10580402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10580402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS research and human retroviruses","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W156536776","https://openalex.org/W1485975527","https://openalex.org/W1509269909","https://openalex.org/W1544816764","https://openalex.org/W1568059997","https://openalex.org/W1580217007","https://openalex.org/W1586015366","https://openalex.org/W1586556343","https://openalex.org/W1982448824","https://openalex.org/W1985511137","https://openalex.org/W1986152436","https://openalex.org/W1995237219","https://openalex.org/W1999168221","https://openalex.org/W2008442265","https://openalex.org/W2008788359","https://openalex.org/W2009825356","https://openalex.org/W2011111568","https://openalex.org/W2021367723","https://openalex.org/W2037343680","https://openalex.org/W2039429451","https://openalex.org/W2041851262","https://openalex.org/W2049947898","https://openalex.org/W2054395379","https://openalex.org/W2055980006","https://openalex.org/W2057723407","https://openalex.org/W2057812330","https://openalex.org/W2060976872","https://openalex.org/W2064557078","https://openalex.org/W2065133594","https://openalex.org/W2066860719","https://openalex.org/W2077348914","https://openalex.org/W2083510193","https://openalex.org/W2092419095","https://openalex.org/W2093044736","https://openalex.org/W2094763220","https://openalex.org/W2102893516","https://openalex.org/W2119542365","https://openalex.org/W2126486896","https://openalex.org/W2133836223","https://openalex.org/W2140202337","https://openalex.org/W2154011163","https://openalex.org/W2161961972","https://openalex.org/W2163942950","https://openalex.org/W2164277825","https://openalex.org/W2166883229","https://openalex.org/W2289287425","https://openalex.org/W2324402215","https://openalex.org/W2330056188","https://openalex.org/W2332941954","https://openalex.org/W2336069963","https://openalex.org/W2419301431","https://openalex.org/W4237274532"],"related_works":["https://openalex.org/W2332941954","https://openalex.org/W2154011163","https://openalex.org/W1992311595","https://openalex.org/W1998668189","https://openalex.org/W2336069963","https://openalex.org/W2154919516","https://openalex.org/W2065397047","https://openalex.org/W2078074864","https://openalex.org/W2027890910","https://openalex.org/W2044794374"],"abstract_inverted_index":{"Members":[0,92],"of":[1,15,43,93,101,137,153,161,177,192],"the":[2,41,53,72,94,159],"Sydney":[3],"Blood":[4],"Bank":[5],"Cohort":[6],"(SBBC)":[7],"have":[8,23],"been":[9],"infected":[10],"with":[11,17,145,164],"an":[12],"attenuated":[13,178],"strain":[14],"HIV-1":[16,148,168,179],"a":[18,173],"natural":[19,165],"nef/LTR":[20,166],"mutation":[21],"and":[22,45,60,63,74,80,87,104,189],"maintained":[24],"relatively":[25],"stable":[26],"CD4+":[27,44,103,112,183],"T":[28,47,106,113,139,156,184,194],"lymphocyte":[29,185],"counts":[30],"for":[31],"14-18":[32],"years.":[33],"Flow":[34],"cytometric":[35],"analysis":[36],"was":[37],"used":[38],"to":[39,129],"examine":[40],"phenotype":[42],"CD8+":[46,105,138,155,193],"lymphocytes":[48,114],"in":[49,169,187],"these":[50,121,170],"subjects,":[51],"including":[52],"immunologically":[54],"important":[55],"naive":[56,102],"(CD45RA+CD62L+),":[57],"primed":[58,110,122],"(CD45RO+),":[59],"activated":[61,154,182],"(CD38+HLA-DR+":[62],"CD28-)":[64],"subsets.":[65],"The":[66],"median":[67],"values":[68],"were":[69],"compared":[70],"between":[71],"SBBC":[73,95,132,143],"control":[75],"groups,":[76],"comprising":[77],"age-,":[78],"sex-,":[79],"transfusion-matched":[81],"HIV-1-uninfected":[82],"subjects;":[83],"transfusion-acquired":[84],"HIV-1-positive":[85,90],"LTNPs;":[86],"sexually":[88],"acquired":[89],"LTNPs.":[91],"not":[96],"only":[97],"had":[98,109,150],"normal":[99,118,151],"levels":[100,152],"lymphocytes,":[107],"but":[108],"CD45RO+":[111],"at":[115],"or":[116],"above":[117],"levels.":[119],"Furthermore,":[120],"cells":[123],"expressed":[124],"markers":[125],"suggesting":[126],"recent":[127],"exposure":[128],"specific":[130],"antigen.":[131],"members":[133,144],"exhibited":[134],"variable":[135],"activation":[136,191],"lymphocytes.":[140,157,195],"In":[141],"particular,":[142],"undetectable":[146],"plasma":[147],"RNA":[149],"Therefore,":[158],"result":[160],"long-term":[162],"infection":[163],"mutant":[167],"subjects":[171],"suggests":[172],"decreased":[174],"cytopathic":[175],"effect":[176],"on":[180],"susceptible":[181],"subsets":[186],"vivo,":[188],"minimal":[190]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
