{"id":"https://openalex.org/W2005367115","doi":"https://doi.org/10.1158/1538-7445.am2014-2982","title":"Abstract 2982: Macrophages modulate adaptive resistance to anti-angiogenic therapy","display_name":"Abstract 2982: Macrophages modulate adaptive resistance to anti-angiogenic therapy","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2005367115","doi":"https://doi.org/10.1158/1538-7445.am2014-2982","mag":"2005367115"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-2982","doi":"https://doi.org/10.1158/1538-7445.am2014-2982","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-2982","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103775706","display_name":"Heather J. Dalton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather J. Dalton","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043392987","display_name":"Sunila Pradeep","orcid":"https://orcid.org/0000-0003-2441-7727","observed_orcids":["https://orcid.org/0000-0003-2441-7727"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunila Pradeep","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060034442","display_name":"Guillermo N. Armaiz-Pe\u00f1a","orcid":"https://orcid.org/0000-0002-9081-5339","observed_orcids":["https://orcid.org/0000-0002-9081-5339"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo N. Armaiz-Pena","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067892203","display_name":"Rebecca A. Previs","orcid":"https://orcid.org/0000-0001-8087-9120","observed_orcids":["https://orcid.org/0000-0001-8087-9120"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Previs","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101654792","display_name":"Ashley N. Davis","orcid":"https://orcid.org/0000-0002-0158-9326","observed_orcids":["https://orcid.org/0000-0002-0158-9326"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Davis","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052973096","display_name":"Rajesha Rupaimoole","orcid":"https://orcid.org/0000-0002-4795-7921","observed_orcids":["https://orcid.org/0000-0002-4795-7921"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesha Rupaimoole","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105369415","display_name":"Behrouz Zand","orcid":"https://orcid.org/0000-0002-8327-3535","observed_orcids":["https://orcid.org/0000-0002-8327-3535"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Behrouz Zand","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088122929","display_name":"Yared Hailemichael","orcid":"https://orcid.org/0000-0003-2619-0634","observed_orcids":["https://orcid.org/0000-0003-2619-0634"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yared Hailemichael","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044032746","display_name":"Willem W. Overwijk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willem W. Overwijk","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542865","display_name":"Gabriel Lopez\u2010Berestein","orcid":"https://orcid.org/0000-0002-0366-0720","observed_orcids":["https://orcid.org/0000-0002-0366-0720"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Lopez-Berestein","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Sood","raw_affiliation_strings":["University of Texas, MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"2982","last_page":"2982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.21559999883174896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9380000233650208},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy-resistance","display_name":"anti-angiogenic therapy resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.878000020980835},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9120000004768372},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.925000011920929},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immune-profiling","display_name":"immune profiling","score":0.7480000257492065},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.718999981880188},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.639197587966919},{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.6213908195495605},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5788657665252686},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.5532947778701782},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.5499512553215027},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5267412066459656},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.5239042043685913},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5223917961120605},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.502526044845581},{"id":"https://openalex.org/C2779482015","wikidata":"https://www.wikidata.org/wiki/Q17121648","display_name":"Tumor-associated macrophage","level":4,"score":0.4648633897304535},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.454500287771225},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4322662949562073},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.4121738076210022},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4079482853412628},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36055415868759155},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33876916766166687},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3220102787017822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29839253425598145},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22407102584838867},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2071222960948944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1760973334312439},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1759680211544037},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17494261264801025},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.1605527102947235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14950847625732422},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-2982","doi":"https://doi.org/10.1158/1538-7445.am2014-2982","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-2982","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2506376590","https://openalex.org/W2751214182","https://openalex.org/W163756401","https://openalex.org/W2740450327","https://openalex.org/W2624491517","https://openalex.org/W2589939875","https://openalex.org/W2015621973","https://openalex.org/W2747510162","https://openalex.org/W4295227032","https://openalex.org/W2476320239"],"abstract_inverted_index":{"Abstract":[0],"Targeted":[1],"anti-angiogenic":[2,303],"therapies":[3],"were":[4,69],"a":[5,44,88,125,148,231,246,258],"highly":[6],"anticipated":[7],"addition":[8,141],"to":[9,97,104,131,137,159,183,218,227,253,262,302],"cancer":[10,47,61],"treatment,":[11,66],"but":[12],"their":[13,235],"clinical":[14],"use":[15],"has":[16],"been":[17],"tempered":[18],"by":[19,147],"the":[20,26,53,100,140,170,309,314],"development":[21],"of":[22,28,59,65,81,95,135,142,151,191,213,223,308,313],"resistance.":[23],"To":[24],"understand":[25],"role":[27,248],"immune":[29,40],"cells":[30,62],"in":[31,43,91,114,117,153,167,187,201,237,251],"potentially":[32],"mediating":[33],"such":[34],"resistance,":[35],"we":[36],"carried":[37],"out":[38],"systematic":[39],"cell":[41,85],"profiling":[42,86],"syngeneic":[45,101],"ovarian":[46,192],"mouse":[48],"model":[49],"following":[50,204,215],"treatment":[51,155,205],"with":[52,93,108,119,139,169,206,266],"B20":[54,105,132,138,162],"anti-VEGF":[55,219,239,254],"antibody.":[56],"Following":[57],"injection":[58],"luciferase-labeled":[60],"and":[63,73,179,256],"initiation":[64],"mice":[67,118],"(n=8/group)":[68],"divided":[70],"into":[71],"B20-sensitive":[72],"resistant":[74,240],"groups":[75],"based":[76],"on":[77],"longitudinal":[78],"bioluminescence":[79,109],"imaging":[80,110,212],"tumor":[82,115,177,202],"burden.":[83],"Immune":[84],"confirmed":[87,196],"dramatic":[89],"increase":[90,113],"macrophages":[92,214,250],"emergence":[94],"resistance":[96,103,252,301],"B20.":[98],"Using":[99],"model,":[102],"was":[106,128,145],"documented":[107],"as":[111,157],"an":[112,238],"burden":[116],"previously":[120],"stable":[121],"disease.":[122],"Zoledronic":[123,165],"acid,":[124],"macrophage-depleting":[126],"bisphosphonate,":[127],"then":[129],"added":[130],"treatment.":[133],"Restoration":[134],"sensitivity":[136],"zoledronic":[143,207],"acid":[144,166],"demonstrated":[146],"68%":[149],"prolongation":[150],"survival":[152],"this":[154,264],"group":[156],"compared":[158,182,226],"those":[160],"receiving":[161],"alone":[163,186],"(p<0.0001).":[164],"combination":[168],"VEGF":[171,224],"antibody,":[172],"bevacizumab,":[173],"significantly":[174,197],"reduced":[175,198],"both":[176],"size":[178],"nodules":[180],"when":[181],"either":[184],"drug":[185],"additional":[188],"orthotopic":[189],"models":[190],"cancer.":[193],"CD68":[194],"staining":[195],"macrophage":[199],"numbers":[200],"samples":[203],"acid.":[208],"In":[209],"vitro":[210],"immunofluorescence":[211],"prolonged":[216],"exposure":[217],"therapy":[220,255],"showed":[221],"downregulation":[222],"receptors":[225],"short-term":[228],"exposure,":[229],"suggesting":[230],"possible":[232],"mechanism":[233],"for":[234,249,317],"persistence":[236],"microenvironment.":[241],"Collectively,":[242],"these":[243],"data":[244],"demonstrate":[245],"novel":[247],"offer":[257],"new":[259],"therapeutic":[260],"strategy":[261],"overcome":[263],"problem":[265],"important":[267],"translational":[268],"implications.":[269],"Citation":[270],"Format:":[271],"Heather":[272],"J.":[273],"Dalton,":[274],"Sunila":[275],"Pradeep,":[276],"Guillermo":[277],"N.":[278],"Armaiz-Pena,":[279],"Rebecca":[280],"Previs,":[281],"Ashley":[282],"Davis,":[283],"Rajesha":[284],"Rupaimoole,":[285],"Behrouz":[286],"Zand,":[287],"Yared":[288],"Hailemichael,":[289],"Willem":[290],"W.":[291],"Overwijk,":[292],"Gabriel":[293],"Lopez-Berestein,":[294],"Anil":[295],"K.":[296],"Sood.":[297],"Macrophages":[298],"modulate":[299],"adaptive":[300],"therapy.":[304],"[abstract].":[305],"In:":[306],"Proceedings":[307],"105th":[310],"Annual":[311],"Meeting":[312],"American":[315],"Association":[316],"Cancer":[318,329],"Research;":[319],"2014":[320],"Apr":[321],"5-9;":[322],"San":[323],"Diego,":[324],"CA.":[325],"Philadelphia":[326],"(PA):":[327],"AACR;":[328],"Res":[330],"2014;74(19":[331],"Suppl):Abstract":[332],"nr":[333],"2982.":[334],"doi:10.1158/1538-7445.AM2014-2982":[335]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
