{"id":"https://openalex.org/W2005366231","doi":"https://doi.org/10.1186/1471-2407-12-219","title":"Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1in laryngeal squamous cell carcinoma","display_name":"Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1in laryngeal squamous cell carcinoma","publication_year":2012,"publication_date":"2012-06-06","ids":{"openalex":"https://openalex.org/W2005366231","doi":"https://doi.org/10.1186/1471-2407-12-219","mag":"2005366231","pmid":"https://pubmed.ncbi.nlm.nih.gov/22672838","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3472177"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-12-219","doi":"https://doi.org/10.1186/1471-2407-12-219","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-12-219","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-12-219","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-12-219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Min Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118294","display_name":"Police Dog Technical School","ror":"https://ror.org/02hhzwx06","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210118294"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yang","raw_affiliation_strings":["Department of Medical Genetics, China Medical University, Shenyang, P.R. China","Shenyang Police-dog Technology School of Ministry of Public Security, Shenyang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Shenyang Police-dog Technology School of Ministry of Public Security, Shenyang, P.R. China","institution_ids":["https://openalex.org/I4210118294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075982592","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-7267-6494","observed_orcids":["https://orcid.org/0000-0002-7267-6494","https://orcid.org/0009-0007-4313-7444"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","ENT Department, the First Affiliated Hospital of China Medical University, Shenyang, 110001, P.R. China","ENT Department, the First Affiliated Hospital of China Medical University, Shenyang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"ENT Department, the First Affiliated Hospital of China Medical University, Shenyang, 110001, P.R. China","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"ENT Department, the First Affiliated Hospital of China Medical University, Shenyang, P.R. China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017085439","display_name":"Yi-Ying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Ying Liu","raw_affiliation_strings":["Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","Department of Medical Genetics, China Medical University, Shenyang, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, P.R.China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101786616","display_name":"Shuang Fu","orcid":"https://orcid.org/0000-0002-9005-5982","observed_orcids":["https://orcid.org/0000-0002-9005-5982"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Fu","raw_affiliation_strings":["Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","Department of Medical Genetics, China Medical University, Shenyang, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, P.R.China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025095484","display_name":"Guang-Bin Qiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-Bin Qiu","raw_affiliation_strings":["Department of Laboratory Medicine, No. 202 Hospital of PLA, Shenyang, 110003, P.R. China","Department of Laboratory Medicine, No. 202 Hospital of PLA, Shenyang, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, No. 202 Hospital of PLA, Shenyang, 110003, P.R. China","institution_ids":[]},{"raw_affiliation_string":"Department of Laboratory Medicine, No. 202 Hospital of PLA, Shenyang, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052099130","display_name":"Kailai Sun","orcid":"https://orcid.org/0000-0003-1648-3409","observed_orcids":["https://orcid.org/0000-0003-1648-3409","https://orcid.org/0000-0001-5902-5534","https://orcid.org/0000-0001-7460-5959"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai-Lai Sun","raw_affiliation_strings":["Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","Department of Medical Genetics, China Medical University, Shenyang, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, P.R.China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035071933","display_name":"Wei\u2010Neng Fu","orcid":"https://orcid.org/0000-0002-0599-1021","observed_orcids":["https://orcid.org/0000-0002-0599-1021"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei-Neng Fu","raw_affiliation_strings":["Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","Department of Medical Genetics, China Medical University, Shenyang, P.R.China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, 110001, P.R. China","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Department of Medical Genetics, China Medical University, Shenyang, P.R.China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035071933"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.315,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.50852777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"219","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cpg-island-methylation","display_name":"CpG island methylation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/transcriptional-downregulation","display_name":"transcriptional downregulation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.925000011920929},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-cell-differentiation","display_name":"tumor cell differentiation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hep-2-cells","display_name":"HEp-2 cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.49300000071525574},{"id":"https://openalex.org/keywords/dna-methylation-markers","display_name":"DNA methylation biomarkers","score":0.5690000057220459},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.32600000500679016},{"id":"https://openalex.org/keywords/chromatin-immunoprecipitation","display_name":"chromatin immunoprecipitation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/luciferase-reporter-assay","display_name":"luciferase reporter assay","score":0.8199999928474426},{"id":"https://openalex.org/keywords/electrophoretic-mobility-shift-assay","display_name":"electrophoretic mobility shift assay","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bisulfite-sequencing","display_name":"bisulfite sequencing","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6927142143249512},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.597615659236908},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5938296318054199},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5903403759002686},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.5518704652786255},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.534368097782135},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5166266560554504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43141457438468933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4253159463405609},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.40142425894737244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3359399437904358},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32764458656311035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08624193072319031}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059372","descriptor_name":"Nucleotide Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2407-12-219","doi":"https://doi.org/10.1186/1471-2407-12-219","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-12-219","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-12-219","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2464054","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3472177","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3472177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3472177","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:22672838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22672838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f533e0bca3dd4c1eb251724ab05bdb46","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f533e0bca3dd4c1eb251724ab05bdb46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 12, Iss 1, p 219 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-12-219","doi":"https://doi.org/10.1186/1471-2407-12-219","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-12-219","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-12-219","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3487814324","display_name":null,"funder_award_id":"81102057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8067599303","display_name":null,"funder_award_id":"81172577","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005366231.pdf","grobid_xml":"https://content.openalex.org/works/W2005366231.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W151228450","https://openalex.org/W1935082899","https://openalex.org/W1970410800","https://openalex.org/W1974643740","https://openalex.org/W1981296878","https://openalex.org/W1984879354","https://openalex.org/W1986449954","https://openalex.org/W1994600118","https://openalex.org/W1998450146","https://openalex.org/W2007811208","https://openalex.org/W2014313104","https://openalex.org/W2027322859","https://openalex.org/W2034502545","https://openalex.org/W2036881307","https://openalex.org/W2037660359","https://openalex.org/W2040848192","https://openalex.org/W2044296075","https://openalex.org/W2055641636","https://openalex.org/W2062348957","https://openalex.org/W2069746308","https://openalex.org/W2070152513","https://openalex.org/W2079458256","https://openalex.org/W2084431624","https://openalex.org/W2086274096","https://openalex.org/W2087832022","https://openalex.org/W2088416146","https://openalex.org/W2089601677","https://openalex.org/W2094777003","https://openalex.org/W2098825279","https://openalex.org/W2116090660","https://openalex.org/W2126150981","https://openalex.org/W2127711905","https://openalex.org/W2131577336","https://openalex.org/W2132593080","https://openalex.org/W2135515956","https://openalex.org/W2136743442","https://openalex.org/W2158035460","https://openalex.org/W2299082307","https://openalex.org/W2383167222","https://openalex.org/W4236512674"],"related_works":["https://openalex.org/W2036881307","https://openalex.org/W131154820","https://openalex.org/W2409798959","https://openalex.org/W2350979111","https://openalex.org/W1545254488","https://openalex.org/W2612396991","https://openalex.org/W2166684236","https://openalex.org/W2481449211","https://openalex.org/W2320617519","https://openalex.org/W2914299835"],"abstract_inverted_index":{"BACKGROUND:":[0],"MYCT1,":[1],"previously":[2],"named":[3],"MTLC,":[4],"is":[5],"a":[6],"novel":[7],"candidate":[8],"tumor":[9],"suppressor":[10],"gene.":[11],"MYCT1":[12,53,86,184,266,296,315,333],"was":[13,89,148,209],"cloned":[14],"from":[15,198,223,252],"laryngeal":[16,120,125,151],"squamous":[17],"cell":[18,176,301],"cancer":[19,121,126,152,175,300],"(LSCC)":[20],"and":[21,54,69,101,123,237,257,297],"has":[22,140],"been":[23,36,141],"found":[24],"to":[25,43,137,156,247,291,312,325],"be":[26,337],"down-regulated":[27],"in":[28,81,87,118,150,160,186,232,303,327,340],"LSCC;":[29],"however,":[30],"the":[31,45,49,82,116,124,133,144,166,214,220,241,244,255,261,270,274,292,308,317],"regulatory":[32],"details":[33],"have":[34],"not":[35],"fully":[37],"elucidated.":[38],"METHODS:":[39],"Here,":[40],"we":[41],"sought":[42],"investigate":[44],"methylation":[46,167,242,306],"status":[47,168],"of":[48,52,78,85,111,115,132,169,183,243,254,260,265,273,295,307,314,331,343],"CpG":[50,113],"islands":[51],"mRNA":[55,181],"levels":[56],"by":[57,91,267,277,320,334],"bisulfite-specific":[58],"PCR":[59],"(BSP)":[60],"based":[61],"on":[62],"sequencing":[63],"restriction":[64],"enzyme":[65],"digestion,":[66],"reverse":[67],"transcription":[68],"real-time":[70],"quantitative":[71],"polymerase":[72],"chain":[73],"reaction":[74],"(RQ-PCR).":[75],"The":[76,107,130,180,195],"function":[77],"specific":[79],"sites":[80,114],"proximal":[83],"promoter":[84,117,276,318],"LSCC":[88],"measured":[90],"transient":[92],"transfection,":[93],"luciferase":[94,196,221],"assays,":[95],"electrophoretic":[96],"mobility":[97],"shift":[98],"assay":[99,104],"(EMSA)":[100],"chromatin":[102],"immunoprecipitation":[103],"(ChIP).":[105],"RESULTS:":[106],"results":[108],"suggested":[109],"hypermethylation":[110,131,289],"12":[112],"both":[119],"tissues":[122,153],"line":[127],"Hep-2":[128,187,233],"cell.":[129],"site":[134,171,249,256,310],"CGCG":[135,245,309],"(-695":[136,246,311],"-692),":[138],"which":[139],"identified":[142,149],"as":[143],"c-Myc":[145,251,278,326],"binding":[146,253,324],"site,":[147],"(59/73)":[154],"compared":[155,212],"paired":[157],"mucosa":[158],"(13/73);":[159],"addition,":[161],"statistical":[162],"analysis":[163],"revealed":[164],"that":[165,240,288],"this":[170,285],"significantly":[172,210],"correlated":[173],"with":[174,190,213,322],"differentiation(p":[177],"<":[178,193,280],"0.01).":[179,194,281],"level":[182],"increased":[185,271],"cells":[188],"treated":[189],"5-aza-C":[191],"(p":[192,279],"activity":[197,222,319],"mutant":[199],"transfectants":[200,225],"pGL3-MYCT1m":[201],"(-852/+12,":[202],"mut-695-C":[203],">":[204,207],"A,":[205],"mut-693-C":[206],"G)":[208],"reduced":[211],"wild":[215,224],"type":[216],"pGL3-MYCT1":[217,226],"(-852/+12),":[218],"while":[219],"(-852/+12)":[227],"rose":[228],"after":[229],"5-aza":[230,268,335],"treatment":[231,259],"cells.":[234],"Finally,":[235],"EMSA":[236],"ChIP":[238],"confirmed":[239],"-692)":[248,313],"prevented":[250],"demethylation":[258],"5'":[262],"flanking":[263],"region":[264],"induced":[269],"occupation":[272],"core":[275],"CONCLUSION:":[282],"In":[283],"summary,":[284],"study":[286],"concluded":[287],"contributed":[290],"transcriptional":[293],"down-regulation":[294],"could":[298],"inhibit":[299],"differentiation":[302],"LSCC.":[304,328,344],"DNA":[305],"altered":[316],"interfering":[321],"its":[323],"Epigenetic":[329],"therapy":[330],"reactivating":[332],"should":[336],"further":[338],"evaluated":[339],"clinical":[341],"trails":[342]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}