{"id":"https://openalex.org/W2005365416","doi":"https://doi.org/10.1002/ijc.2910110102","title":"Cellular and humoral immunity to rat hepatoma\u2010specific antigens correlated with tumour status","display_name":"Cellular and humoral immunity to rat hepatoma\u2010specific antigens correlated with tumour status","publication_year":1973,"publication_date":"1973-01-15","ids":{"openalex":"https://openalex.org/W2005365416","doi":"https://doi.org/10.1002/ijc.2910110102","mag":"2005365416","pmid":"https://pubmed.ncbi.nlm.nih.gov/4133609"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910110102","doi":"https://doi.org/10.1002/ijc.2910110102","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910110102","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108382892","display_name":"Robert W. Baldwin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. W. Baldwin","raw_affiliation_strings":["Cancer Research Campaign Laboratories, University of Nottingham, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Laboratories, University of Nottingham, England","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111836819","display_name":"M. J. Embleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. J. Embleton","raw_affiliation_strings":["Cancer Research Campaign Laboratories, University of Nottingham, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Laboratories, University of Nottingham, England","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108089910","display_name":"R. A. Robins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. A. Robins","raw_affiliation_strings":["Cancer Research Campaign Laboratories, University of Nottingham, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Campaign Laboratories, University of Nottingham, England","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":8.6277,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.98409275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-specific-immunity","display_name":"tumor-specific immunity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.734000027179718},{"id":"https://openalex.org/keywords/antibody-mediated-cytotoxicity","display_name":"antibody-mediated cytotoxicity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/tumour-excision","display_name":"tumour excision","score":0.6209999918937683},{"id":"https://openalex.org/keywords/repeated-vaccination","display_name":"repeated vaccination","score":0.5799999833106995},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.9141162037849426},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.7285695672035217},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7039234638214111},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6360471844673157},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6195912957191467},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6184375286102295},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5494087934494019},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5296879410743713},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5103752017021179},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.4918546676635742},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4668472707271576},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4489901065826416},{"id":"https://openalex.org/C45121317","wikidata":"https://www.wikidata.org/wiki/Q4927287","display_name":"Blocking antibody","level":3,"score":0.44060465693473816},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25664418935775757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23941099643707275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.061578720808029175}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910110102","doi":"https://doi.org/10.1002/ijc.2910110102","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910110102","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:4133609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4133609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1906464993","https://openalex.org/W1964143165","https://openalex.org/W1981067568","https://openalex.org/W1995953165","https://openalex.org/W1998339993","https://openalex.org/W2002441956","https://openalex.org/W2016134533","https://openalex.org/W2024344753","https://openalex.org/W2029985668","https://openalex.org/W2037195433","https://openalex.org/W2069319055","https://openalex.org/W2072297242","https://openalex.org/W2076958184","https://openalex.org/W2083449454","https://openalex.org/W2103984051","https://openalex.org/W2130076809"],"related_works":["https://openalex.org/W1988695983","https://openalex.org/W2011832120","https://openalex.org/W2072297242","https://openalex.org/W2153944711","https://openalex.org/W2083449454","https://openalex.org/W1264820825","https://openalex.org/W389618133","https://openalex.org/W3047541287","https://openalex.org/W2081541692","https://openalex.org/W2085363564"],"abstract_inverted_index":{"Abstract":[0],"Lymphocytes":[1],"from":[2,97],"rats":[3,98],"bearing":[4],"primary":[5],"or":[6],"transplanted":[7,46],"aminoazo\u2010dye\u2010induced":[8],"hepatomas":[9],"were":[10,41,51],"specifically":[11],"cytotoxic":[12,48,92,107],"for":[13,89],"cells":[14,50],"of":[15,27,34,45,66,85,106,122,137],"the":[16,25,83,119,123,131,135,142,148],"same":[17],"tumour.":[18],"Cytotoxic":[19,70],"antibody":[20,71,108],"was":[21,72],"not":[22],"present":[23,73],"in":[24,39,62,74,116,134],"serum":[26,75,86,96,136],"these":[28],"animals,":[29],"although":[30],"humoral":[31],"factors":[32,133],"capable":[33],"abrogating":[35],"lymph\u2010node":[36,49,90,113],"cell\u2010mediated":[37,91,114],"cytotoxicity":[38],"vitro":[40],"detected.":[42],"Following":[43],"excision":[44],"hepatomas,":[47,102],"still":[52],"demonstrable,":[53],"with":[54,82],"slightly":[55],"increased":[56],"reactivities":[57],"comparable":[58],"to":[59,101],"those":[60],"detected":[61],"a":[63],"previous":[64],"study":[65],"repeatedly":[67,99],"immunized":[68,100],"rats.":[69],"after":[76],"tumour":[77],"excision,":[78],"and":[79,139,147],"this":[80],"correlates":[81],"loss":[84],"blocking":[87,132],"activity":[88],"effects.":[93],"In":[94],"comparison,":[95],"where":[103],"high":[104],"levels":[105],"are":[109],"also":[110],"present,":[111],"blocks":[112],"reactions":[115],"vitro,":[117],"despite":[118],"immune":[120],"status":[121],"donor.":[124],"These":[125],"considerations":[126],"suggest":[127],"qualitative":[128],"differences":[129],"between":[130],"tumour\u2010bearer":[138],"tumour\u2010immune":[140],"hosts,":[141],"former":[143],"being":[144],"antigen\u2010antibody":[145],"complexes,":[146],"latter":[149],"free":[150],"antibody.":[151]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}