{"id":"https://openalex.org/W2005362904","doi":"https://doi.org/10.1016/0046-8177(90)90073-e","title":"P-glycoproteins in pathology: The multidrug resistance gene family in humans","display_name":"P-glycoproteins in pathology: The multidrug resistance gene family in humans","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2005362904","doi":"https://doi.org/10.1016/0046-8177(90)90073-e","mag":"2005362904","pmid":"https://pubmed.ncbi.nlm.nih.gov/1967244"},"language":"en","primary_location":{"id":"doi:10.1016/0046-8177(90)90073-e","doi":"https://doi.org/10.1016/0046-8177(90)90073-e","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0046-8177(90)90073-e","pdf_url":null,"source":{"id":"https://openalex.org/S63477337","display_name":"Human Pathology","issn_l":"0046-8177","issn":["0046-8177","1532-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058560274","display_name":"Ronald S. Weinstein","orcid":"https://orcid.org/0000-0003-3272-9587","observed_orcids":["https://orcid.org/0000-0003-3272-9587"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald S. Weinstein","raw_affiliation_strings":["Department of Pathology, Rush University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rush University, Chicago, IL","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110111779","display_name":"Jerome R. Kuszak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome R. Kuszak","raw_affiliation_strings":["Department of Pathology, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082805651","display_name":"Larry F. Kluskens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry F. Kluskens","raw_affiliation_strings":["Department of Pathology, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024450756","display_name":"John Sayler Coon","orcid":"https://orcid.org/0000-0003-0521-0157","observed_orcids":["https://orcid.org/0000-0003-0521-0157"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Coon","raw_affiliation_strings":["Department of Pathology, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Rush University and Rush-Presbyterian-St Luke's Medical Center, Chicago, IL USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058560274"],"corresponding_institution_ids":["https://openalex.org/I49886154"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":3.0275,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.92485549,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"1","first_page":"34","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8410000205039978},{"id":"https://openalex.org/keywords/abcb1-gene","display_name":"MDR1 gene","score":0.925000011920929},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8659999966621399},{"id":"https://openalex.org/keywords/intrinsic-drug-resistance","display_name":"intrinsic drug resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7450000047683716},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mdr1-mrna-expression","display_name":"MDR1 mRNA expression","score":0.7379999756813049},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.49300000071525574},{"id":"https://openalex.org/keywords/chemosensitivity-testing","display_name":"chemosensitivity testing","score":0.6600000262260437},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.7788625955581665},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6911863684654236},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.5764700174331665},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.524002194404602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5232250094413757},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5135067105293274},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4831916391849518},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.46060898900032043},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41521164774894714},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4131067097187042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24660086631774902}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0046-8177(90)90073-e","doi":"https://doi.org/10.1016/0046-8177(90)90073-e","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0046-8177(90)90073-e","pdf_url":null,"source":{"id":"https://openalex.org/S63477337","display_name":"Human Pathology","issn_l":"0046-8177","issn":["0046-8177","1532-8392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Pathology","raw_type":"journal-article"},{"id":"pmid:1967244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1967244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":136,"referenced_works":["https://openalex.org/W35929032","https://openalex.org/W79317665","https://openalex.org/W85883899","https://openalex.org/W101324336","https://openalex.org/W124506353","https://openalex.org/W175263069","https://openalex.org/W206245615","https://openalex.org/W572492997","https://openalex.org/W588619189","https://openalex.org/W1487550059","https://openalex.org/W1516556486","https://openalex.org/W1530730239","https://openalex.org/W1531911812","https://openalex.org/W1545285984","https://openalex.org/W1560326407","https://openalex.org/W1567907251","https://openalex.org/W1569642404","https://openalex.org/W1571215201","https://openalex.org/W1572013196","https://openalex.org/W1587491680","https://openalex.org/W1594230811","https://openalex.org/W1595352454","https://openalex.org/W1613470888","https://openalex.org/W1750480583","https://openalex.org/W1754065147","https://openalex.org/W1808300903","https://openalex.org/W1854656596","https://openalex.org/W1858200607","https://openalex.org/W1865504766","https://openalex.org/W1872023806","https://openalex.org/W1964470226","https://openalex.org/W1967004837","https://openalex.org/W1969795656","https://openalex.org/W1971950332","https://openalex.org/W1973600640","https://openalex.org/W1977561982","https://openalex.org/W1979783027","https://openalex.org/W1982367447","https://openalex.org/W1986759928","https://openalex.org/W1991925356","https://openalex.org/W1996808398","https://openalex.org/W1997241897","https://openalex.org/W1997834751","https://openalex.org/W1998287390","https://openalex.org/W2003841519","https://openalex.org/W2005890366","https://openalex.org/W2007931369","https://openalex.org/W2007965142","https://openalex.org/W2009007332","https://openalex.org/W2009979935","https://openalex.org/W2012766451","https://openalex.org/W2013279579","https://openalex.org/W2013540958","https://openalex.org/W2014593961","https://openalex.org/W2016102145","https://openalex.org/W2018577228","https://openalex.org/W2018652769","https://openalex.org/W2020931673","https://openalex.org/W2021769734","https://openalex.org/W2024463580","https://openalex.org/W2025603165","https://openalex.org/W2028265922","https://openalex.org/W2028533496","https://openalex.org/W2029185839","https://openalex.org/W2030686317","https://openalex.org/W2035173202","https://openalex.org/W2035660841","https://openalex.org/W2036518418","https://openalex.org/W2037621239","https://openalex.org/W2039358467","https://openalex.org/W2040862799","https://openalex.org/W2045875829","https://openalex.org/W2053379947","https://openalex.org/W2057490489","https://openalex.org/W2058215061","https://openalex.org/W2058825253","https://openalex.org/W2059584690","https://openalex.org/W2069279033","https://openalex.org/W2075749214","https://openalex.org/W2078877172","https://openalex.org/W2080913148","https://openalex.org/W2082403812","https://openalex.org/W2091259347","https://openalex.org/W2095527574","https://openalex.org/W2097878215","https://openalex.org/W2102071915","https://openalex.org/W2103047564","https://openalex.org/W2107615796","https://openalex.org/W2109923623","https://openalex.org/W2112093320","https://openalex.org/W2117398529","https://openalex.org/W2118069529","https://openalex.org/W2121167726","https://openalex.org/W2130651544","https://openalex.org/W2132084215","https://openalex.org/W2135923360","https://openalex.org/W2136386901","https://openalex.org/W2136900732","https://openalex.org/W2138791276","https://openalex.org/W2148954987","https://openalex.org/W2150403997","https://openalex.org/W2150552611","https://openalex.org/W2152029190","https://openalex.org/W2153712534","https://openalex.org/W2158271452","https://openalex.org/W2161663775","https://openalex.org/W2163636540","https://openalex.org/W2198182531","https://openalex.org/W2210404574","https://openalex.org/W2223026985","https://openalex.org/W2240907549","https://openalex.org/W2257345960","https://openalex.org/W2261384353","https://openalex.org/W2264155967","https://openalex.org/W2315951127","https://openalex.org/W2401304387","https://openalex.org/W2407848070","https://openalex.org/W2408357934","https://openalex.org/W2409701566","https://openalex.org/W2416796041","https://openalex.org/W2423315740","https://openalex.org/W2435958575","https://openalex.org/W2484177604","https://openalex.org/W2506707661","https://openalex.org/W2615953705","https://openalex.org/W4253385789","https://openalex.org/W4301410953","https://openalex.org/W6632377654","https://openalex.org/W6634087032","https://openalex.org/W6634117205","https://openalex.org/W6634139598","https://openalex.org/W6635529493","https://openalex.org/W6651954612","https://openalex.org/W6675233531","https://openalex.org/W6675445383","https://openalex.org/W6677604402"],"related_works":["https://openalex.org/W15761847","https://openalex.org/W2024463580","https://openalex.org/W55733238","https://openalex.org/W2441333899","https://openalex.org/W1486397882","https://openalex.org/W2060137120","https://openalex.org/W2409701566","https://openalex.org/W4245797813","https://openalex.org/W1996669297","https://openalex.org/W392253643"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
