{"id":"https://openalex.org/W2005360149","doi":"https://doi.org/10.1097/00004872-199511000-00005","title":"Mapping and sequence analysis of the gene encoding the beta subunit of the epithelial sodium channel in experimental models of hypertension","display_name":"Mapping and sequence analysis of the gene encoding the beta subunit of the epithelial sodium channel in experimental models of hypertension","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2005360149","doi":"https://doi.org/10.1097/00004872-199511000-00005","mag":"2005360149","pmid":"https://pubmed.ncbi.nlm.nih.gov/8984121"},"language":"en","primary_location":{"id":"doi:10.1097/00004872-199511000-00005","doi":"https://doi.org/10.1097/00004872-199511000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199511000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103260456","display_name":"Huaming Huang","orcid":"https://orcid.org/0000-0003-2823-9446","observed_orcids":["https://orcid.org/0000-0003-2823-9446"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaming Huang","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, USA","the Department of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033492851","display_name":"Michal Pravenec","orcid":"https://orcid.org/0000-0001-9197-5871","observed_orcids":["https://orcid.org/0000-0001-9197-5871"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210166371","display_name":"Czech Academy of Sciences, Institute of Physiology","ror":"https://ror.org/05xw0ep96","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210166371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Michal Pravenec","raw_affiliation_strings":["Institute of Physiology, Czech Academy of Sciences, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Czech Academy of Sciences, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210166371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631349","display_name":"Jiaming Wang","orcid":"https://orcid.org/0000-0002-5504-4276","observed_orcids":["https://orcid.org/0000-0002-5504-4276"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia-Ming Wang","raw_affiliation_strings":["the Department of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112148505","display_name":"Vladim\u00edr K\u0159en","orcid":"https://orcid.org/0000-0002-1091-4020","observed_orcids":["https://orcid.org/0000-0002-1091-4020"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Vladimir Kren","raw_affiliation_strings":["Department of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, 1st Medical Faculty, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055487942","display_name":"Elizabeth St. Lezin","orcid":"https://orcid.org/0000-0001-6191-3418","observed_orcids":["https://orcid.org/0000-0001-6191-3418"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth St Lezin","raw_affiliation_strings":["the Department of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067204984","display_name":"Claude Szpirer","orcid":"https://orcid.org/0000-0002-2674-5938","observed_orcids":["https://orcid.org/0000-0002-2674-5938"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Claude Szpirer","raw_affiliation_strings":["Department of Molecular Biology, University Libre de Bruxelles, Rhode-St-Genese, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University Libre de Bruxelles, Rhode-St-Genese, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010898796","display_name":"Josiane Szpirer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Josiane Szpirer","raw_affiliation_strings":["Department of Molecular Biology, University Libre de Bruxelles, Rhode-St-Genese, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University Libre de Bruxelles, Rhode-St-Genese, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091609730","display_name":"Theodore W. Kurtz","orcid":"https://orcid.org/0000-0003-0436-5456","observed_orcids":["https://orcid.org/0000-0003-0436-5456"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore W. Kurtz","raw_affiliation_strings":["the Department of Laboratory Medicine, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Laboratory Medicine, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033492851"],"corresponding_institution_ids":["https://openalex.org/I202391551","https://openalex.org/I21250087","https://openalex.org/I4210166371"],"apc_list":null,"apc_paid":null,"fwci":3.8358,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93622248,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"11","first_page":"1247","last_page":"1251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.673799991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.673799991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.11559999734163284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.953000009059906},{"id":"https://openalex.org/keywords/scnn1b","display_name":"SCNN1B","score":0.8880000114440918},{"id":"https://openalex.org/keywords/beta-subunit","display_name":"beta subunit","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6809999942779541},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dahl-salt-sensitive-rats","display_name":"Dahl salt-sensitive rats","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chromosome-mapping","display_name":"chromosome mapping","score":0.6119999885559082},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.5839999914169312},{"id":"https://openalex.org/keywords/recombinant-inbred-lines","display_name":"recombinant inbred lines","score":0.9039999842643738},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.4819999933242798},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6914733648300171},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6727347373962402},{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.5177449584007263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4859718084335327},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.42253953218460083},{"id":"https://openalex.org/C165237769","wikidata":"https://www.wikidata.org/wiki/Q765245","display_name":"Chromosome 15","level":4,"score":0.42030608654022217},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4191821217536926},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4011499881744385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3313438892364502},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.12275099754333496},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011918","descriptor_name":"Rats, Inbred SHR","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00004872-199511000-00005","doi":"https://doi.org/10.1097/00004872-199511000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004872-199511000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:8984121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8984121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/95061","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/95061","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of hypertension, 13 (11","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2128405407","https://openalex.org/W2052096747","https://openalex.org/W3168876757","https://openalex.org/W2008696153","https://openalex.org/W2146306437","https://openalex.org/W2170464107","https://openalex.org/W2119979251","https://openalex.org/W2336829704","https://openalex.org/W2077359423","https://openalex.org/W2188778296"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"whether":[3],"mutations":[4,163],"in":[5,21,77,101,141,185,193,215,227,234],"the":[6,10,17,22,28,35,39,127,142,167,173,182,194,204,211,216,238,243],"beta":[7],"subunit":[8],"of":[9,19,38,147,172,188,197,203,213,242],"epithelial":[11,205],"sodium":[12,207,245],"channel":[13,208,246],"(Scnn1b)":[14],"contribute":[15],"to":[16,126,158,210,237],"pathogenesis":[18,212],"hypertension":[20,214],"spontaneously":[23],"hypertensive":[24],"rat":[25,40,117,131,189],"(SHR)":[26],"and":[27,49,59,73,84,98,154],"Dahl":[29,60,155,219],"salt-sensitive":[30,61],"rat.":[31],"DESIGN:":[32],"We":[33],"determined":[34],"chromosome":[36,132,190],"location":[37],"Scnn1b":[41,53,99,121,139,150,174,178,231],"gene,":[42],"tested":[43],"for":[44,93],"cosegregation":[45],"with":[46,138],"blood":[47,96,198],"pressure,":[48],"sequenced":[50],"near":[51,148,181],"full-length":[52,149],"complementary":[54],"DNAs":[55],"(cDNAs)":[56],"from":[57,82,111,116,152,224],"SHR":[58,83,153,217],"rats.":[62,86],"METHODS:":[63],"Chromosome":[64],"mapping":[65],"was":[66,89,106,123],"performed":[67,90,107],"by":[68,74,91],"somatic":[69],"cell":[70,206],"hybrid":[71],"analysis":[72,76,88],"linkage":[75],"recombinant":[78,143],"inbred":[79,144],"strains":[80],"derived":[81,115],"Brown-Norway":[85],"Cosegregation":[87],"testing":[92],"correlations":[94],"between":[95],"pressure":[97,135],"genotypes":[100],"these":[102],"strains.":[103,145],"DNA":[104],"sequencing":[105],"on":[108,130],"cDNAs":[109,151],"prepared":[110],"reverse-transcribed":[112],"messenger":[113],"RNA":[114],"kidney.":[118],"RESULTS:":[119],"The":[120,177],"gene":[122,129,140,179,184],"closely":[124],"linked":[125],"Sa":[128,183],"1.":[133],"Blood":[134],"correlated":[136],"significantly":[137],"Analysis":[146],"rats":[156],"failed":[157],"reveal":[159],"any":[160],"coding":[161],"sequence":[162,171],"that":[164,229],"could":[165],"affect":[166],"predicted":[168],"amino":[169],"acid":[170],"protein.":[175],"CONCLUSION:":[176],"maps":[180],"a":[186],"region":[187],"1":[191],"involved":[192],"inherited":[195],"control":[196],"pressure.":[199],"If":[200],"disordered":[201],"activity":[202],"contributes":[209],"or":[218,233,240],"models,":[220],"it":[221],"must":[222],"stem":[223],"genetic":[225],"lesions":[226],"sequences":[228,235],"regulate":[230],"function":[232,241],"important":[236],"structure":[239],"other":[244],"subunits.":[247]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}