{"id":"https://openalex.org/W200535495","doi":null,"title":"[New approach to obsessive-compulsive disorder: dopaminergic theories].","display_name":"[New approach to obsessive-compulsive disorder: dopaminergic theories].","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W200535495","mag":"200535495","pmid":"https://pubmed.ncbi.nlm.nih.gov/18167420"},"language":"hu","primary_location":{"id":"pmid:18167420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18167420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata","raw_type":"English Abstract"},"parent_works":[],"lineage":["https://openalex.org/W200535495"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026634064","display_name":"Andr\u00e1s Hars\u00e1nyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106030","display_name":"National Institute of Menthal Health, Neurology and Neurosurgery - Ny\u00edr\u0151 Gyula Hospital","ror":"https://ror.org/01f091k66","country_code":"HU","type":"healthcare","lineage":["https://openalex.org/I4210106030"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Andr\u00e1s Hars\u00e1nyi","raw_affiliation_strings":["Nyir\u00f4 Gyula K\u00f3rh\u00e1z, II. Pszichi\u00e1triai Oszt\u00e1ly, Budapest, Hungary. harsanyi@nygyk.hu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nyir\u00f4 Gyula K\u00f3rh\u00e1z, II. Pszichi\u00e1triai Oszt\u00e1ly, Budapest, Hungary. harsanyi@nygyk.hu","institution_ids":["https://openalex.org/I4210106030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024626549","display_name":"Katalin Csig\u00f3","orcid":"https://orcid.org/0009-0004-0317-7095","observed_orcids":["https://orcid.org/0009-0004-0317-7095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katalin Csig\u00f3","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035910205","display_name":"Gyula Demeter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gyula Demeter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Attila N\u00e9meth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Attila N\u00e9meth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0728,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85694903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"22","issue":"4","first_page":"248","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":1.0},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9750000238418579},{"id":"https://openalex.org/keywords/antipsychotic-augmentation","display_name":"antipsychotic augmentation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/comt-gene","display_name":"COMT gene","score":0.8949999809265137},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.6700000166893005},{"id":"https://openalex.org/keywords/neurotransmitter-systems","display_name":"neurotransmitter systems","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7182554006576538},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7148013114929199},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7048567533493042},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6549843549728394},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.5716724991798401},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5443292856216431},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.539074182510376},{"id":"https://openalex.org/C2776743251","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Ventral striatum","level":4,"score":0.5226519107818604},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.504177451133728},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.4649827182292938},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.3496871292591095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29169541597366333},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2072751820087433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17828580737113953},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11437094211578369},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08563500642776489},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18167420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18167420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata","raw_type":"English Abstract"},{"id":"mag:200535495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18167420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412630710","https://openalex.org/W18127766","https://openalex.org/W2042126575","https://openalex.org/W2134768080","https://openalex.org/W2120128279","https://openalex.org/W109318319","https://openalex.org/W2022266738","https://openalex.org/W2936832291","https://openalex.org/W3137360377","https://openalex.org/W4237372172"],"abstract_inverted_index":{"In":[0,154,227],"patients":[1,167],"with":[2,172],"obsessive-compulsive":[3],"disorder":[4],"(OCD),":[5],"structural":[6],"and":[7,22,54,93,119],"volumetric":[8],"abnormalities":[9],"have":[10,145,177],"been":[11,37,114],"identified":[12],"by":[13,39,116,120,170],"up-to-date":[14],"neuroimaging":[15,40,117],"techniques":[16,118],"both":[17],"in":[18,23,50,57,134,148,191],"the":[19,24,51,58,64,72,77,80,89,95,106,128,138,141,149,159,179,187,203,211,221],"prefrontal":[20,52],"region":[21],"basal":[25,59],"ganglia":[26],"(striatum,":[27],"thalamus,":[28],"amygdala).":[29],"The":[30,61,84,125,193],"dysfunction":[31,62],"of":[32,63,74,97,127,151,161,165,182,195,206,210,215,220,235,242],"these":[33,98,183,196,236],"regions":[34,214],"also":[35,200],"has":[36,113],"proved":[38],"techniques.":[41],"These":[42],"alterations":[43],"can":[44,136],"be":[45,137],"described":[46],"as":[47,123],"dopaminergic":[48,108,173],"hyperfunction":[49],"cortex":[53],"serotonergic":[55,86,102],"hypofunction":[56,103],"ganglia.":[60],"so-called":[65],"'cortico-striato-thalamic'":[66],"loops":[67,109,190,198],"is":[68,79,104,199],"strongly":[69],"linked":[70],"to":[71,202],"symptoms":[73],"OCD,":[75,207],"where":[76],"dopamine":[78,222],"most":[81],"dominant":[82],"neurotransmitter.":[83],"ascending":[85],"projections":[87],"from":[88],"raphe":[90],"nuclei":[91],"restrain":[92],"control":[94],"function":[96],"loops.":[99],"Thus,":[100],"when":[101],"present,":[105],"predominantly":[107],"became":[110],"overactive,":[111],"which":[112],"confirmed":[115,178],"neurocognitive":[121],"tests":[122],"well.":[124],"linkage":[126],"two":[129],"predominant":[130],"neurotransmitter":[131],"systems":[132],"affected":[133],"OCD":[135,152,166,216,243],"reason":[139],"for":[140],"fact":[142],"that":[143],"SSRIs":[144],"limited":[146],"success":[147],"treatment":[150,160],"symptoms.":[153],"recent":[155,240],"international,":[156],"multicentric":[157],"studies,":[158],"SSRI":[162],"non-responder":[163],"subgroup":[164],"were":[168],"supplemented":[169],"antipsychotics":[171],"activity.":[174],"Many":[175],"studies":[176],"beneficial":[180],"effect":[181],"antidopaminergic":[184],"substances":[185],"on":[186,239],"hyperactive":[188],"cortico-striato-thalamic":[189],"OCD.":[192],"investigation":[194],"dysfunctional":[197],"connected":[201],"genetic":[204],"background":[205],"because":[208],"some":[209],"candidate":[212],"gene":[213],"are":[217],"coding":[218],"proteins":[219],"synthesis":[223],"(for":[224],"example:":[225],"COMT).":[226],"this":[228],"paper,":[229],"we":[230],"present":[231],"a":[232],"detailed":[233],"overview":[234],"relationships":[237],"based":[238],"findings":[241],"research.":[244]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}