{"id":"https://openalex.org/W2005354443","doi":"https://doi.org/10.1021/om049679w","title":"Synthesis, Characterization, and Assessment of Cytotoxic Properties of a Series of Titanocene Dichloride Derivatives","display_name":"Synthesis, Characterization, and Assessment of Cytotoxic Properties of a Series of Titanocene Dichloride Derivatives","publication_year":2004,"publication_date":"2004-08-20","ids":{"openalex":"https://openalex.org/W2005354443","doi":"https://doi.org/10.1021/om049679w","mag":"2005354443"},"language":"en","primary_location":{"id":"doi:10.1021/om049679w","doi":"https://doi.org/10.1021/om049679w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/om049679w","pdf_url":null,"source":{"id":"https://openalex.org/S4924609","display_name":"Organometallics","issn_l":"0276-7333","issn":["0276-7333","1520-6041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organometallics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082200026","display_name":"Patrick W. Causey","orcid":"https://orcid.org/0000-0002-7606-2836","observed_orcids":["https://orcid.org/0000-0002-7606-2836"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick W. Causey","raw_affiliation_strings":["Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020080609","display_name":"Michael C. Baird","orcid":"https://orcid.org/0000-0002-1497-3511","observed_orcids":["https://orcid.org/0000-0002-1497-3511"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Michael C. Baird","raw_affiliation_strings":["Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044399566","display_name":"Susan P.C. Cole","orcid":"https://orcid.org/0000-0001-6571-6884","observed_orcids":["https://orcid.org/0000-0001-6571-6884"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Susan P. C. Cole","raw_affiliation_strings":["Cancer Research Laboratories, Queen's University, Kingston, Ontario, Canada K7L 3N6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratories, Queen's University, Kingston, Ontario, Canada K7L 3N6","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020080609"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.6975,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.96556026,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"19","first_page":"4486","last_page":"4494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12458","display_name":"Organometallic Compounds Synthesis and Characterization","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titanocene-dichloride","display_name":"titanocene dichloride","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cyclopentadienyl-complexes","display_name":"cyclopentadienyl complexes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/dicationic-complexes","display_name":"dicationic complexes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lung-cancer-cell-lines","display_name":"lung cancer cell lines","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ovarian-cancer-cell-lines","display_name":"ovarian cancer cell lines","score":1.0},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.921999990940094},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7179999947547913},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9666777849197388},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8241880536079407},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7679671049118042},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.760296106338501},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6496556997299194},{"id":"https://openalex.org/C181458950","wikidata":"https://www.wikidata.org/wiki/Q2855060","display_name":"Cyclopentadienyl complex","level":3,"score":0.5735955834388733},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5111787915229797},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.34114551544189453},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16970273852348328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11141747236251831},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07470199465751648},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/om049679w","doi":"https://doi.org/10.1021/om049679w","is_oa":false,"landing_page_url":"https://doi.org/10.1021/om049679w","pdf_url":null,"source":{"id":"https://openalex.org/S4924609","display_name":"Organometallics","issn_l":"0276-7333","issn":["0276-7333","1520-6041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organometallics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W28217284","https://openalex.org/W1963779283","https://openalex.org/W1974990350","https://openalex.org/W1978689713","https://openalex.org/W1991410119","https://openalex.org/W1991565868","https://openalex.org/W1991588605","https://openalex.org/W1992042155","https://openalex.org/W2006136788","https://openalex.org/W2006325254","https://openalex.org/W2012108057","https://openalex.org/W2013399673","https://openalex.org/W2014588550","https://openalex.org/W2015202052","https://openalex.org/W2016814864","https://openalex.org/W2019724950","https://openalex.org/W2020992881","https://openalex.org/W2036788625","https://openalex.org/W2040069987","https://openalex.org/W2050545246","https://openalex.org/W2062147018","https://openalex.org/W2074888759","https://openalex.org/W2075916950","https://openalex.org/W2083484180","https://openalex.org/W2083526260","https://openalex.org/W2090974779","https://openalex.org/W2097272023","https://openalex.org/W2114918609","https://openalex.org/W2155208683","https://openalex.org/W2168940441","https://openalex.org/W2241061912","https://openalex.org/W2401083660","https://openalex.org/W2419075599","https://openalex.org/W2952165521","https://openalex.org/W3004576110"],"related_works":["https://openalex.org/W4249405563","https://openalex.org/W1975031493","https://openalex.org/W2079114825","https://openalex.org/W2088102600","https://openalex.org/W2168940441","https://openalex.org/W7097951864","https://openalex.org/W2183399984","https://openalex.org/W1969608306","https://openalex.org/W2100931770","https://openalex.org/W1975673877"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,31,35,64,80,92,100,143,150],"15":[3],"water-soluble":[4],"titanocene":[5,81],"dichloride":[6,82],"derivatives":[7,125],"containing":[8,126,136],"alkylammonium":[9],"groups":[10],"pendant":[11],"to":[12,106],"one":[13],"(monocationic":[14],"complexes)":[15,19],"or":[16,139],"both":[17,65],"(dicationic":[18],"cyclopentadienyl":[20],"rings":[21,129],"has":[22],"been":[23,40],"synthesized":[24],"and":[25,49,56,76,124,160],"characterized.":[26],"The":[27],"in":[28],"vitro":[29],"cytotoxicities":[30,63],"this":[32],"small":[33],"library":[34],"potential":[36],"anticancer":[37],"drugs":[38],"have":[39],"assessed":[41],"against":[42,87],"human":[43],"lung":[44],"cancer":[45,51],"(H209,":[46],"A549,":[47],"H209/CP)":[48],"ovarian":[50],"(A2780,":[52],"A2780/CP)":[53],"cell":[54],"lines,":[55],"the":[57,62,93,107,120,144],"results":[58],"are":[59,103],"compared":[60],"with":[61],"cisplatin":[66],"(":[67],"cis":[68],"-PtCl":[69],"2":[70,74],"(NH":[71],"3":[72],")":[73,75],"a":[77,147],"clinical":[78,108],"formulation":[79],"that":[83,99],"is":[84],"commonly":[85],"used":[86],"cisplatin-resistant":[88],"tumors.":[89],"While":[90],"none":[91],"compounds":[94,135],"exhibit":[95,115,130],"potency":[96,117,132],"greater":[97,116,131],"than":[98,118,133],"cisplatin,":[101],"several":[102],"clearly":[104],"superior":[105],"formulation.":[109],"In":[110],"particular":[111],"dicationic":[112],"complexes":[113],"generally":[114],"do":[119,134],"corresponding":[121],"monocationic":[122],"analogues,":[123],"protonated":[127,137],"piperidinyl":[128],"2-aminoethyl":[138],"3-aminopropyl":[140],"groups.":[141],"Eight":[142],"compounds,":[145],"representing":[146],"wide":[148],"range":[149],"potencies,":[151],"were":[152,162],"characterized":[153],"crystallographically":[154],"but":[155],"no":[156],"correlations":[157],"between":[158],"effectiveness":[159],"structures":[161],"obvious.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}