{"id":"https://openalex.org/W2005353094","doi":"https://doi.org/10.1016/0014-5793(94)01348-5","title":"Pro\u2010oxidant effects of 7\u2010hydroperoxycholest\u20105\u2010en\u20103\u03b2\u2010ol on the copper\u2010initiated oxidation of low density lipoprotein","display_name":"Pro\u2010oxidant effects of 7\u2010hydroperoxycholest\u20105\u2010en\u20103\u03b2\u2010ol on the copper\u2010initiated oxidation of low density lipoprotein","publication_year":1995,"publication_date":"1995-01-03","ids":{"openalex":"https://openalex.org/W2005353094","doi":"https://doi.org/10.1016/0014-5793(94)01348-5","mag":"2005353094","pmid":"https://pubmed.ncbi.nlm.nih.gov/7805879"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(94)01348-5","doi":"https://doi.org/10.1016/0014-5793(94)01348-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(94)01348-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2894%2901348-5","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2894%2901348-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110003241","display_name":"Denis Blache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I177064439","display_name":"Universit\u00e9 de Bourgogne","ror":"https://ror.org/03k1bsr36","country_code":"FR","type":"education","lineage":["https://openalex.org/I177064439","https://openalex.org/I4405253280"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Blache","raw_affiliation_strings":["INSERM CJF 93-10, Laboratoire de Biochimie des Lipoprot\u00e9ines, Universit\u00e9 de Bourgogne, Dijon, France","INSERM CJF 93-10, Laboratoire de Biochimie des Lipoprot\u00e9ines, Universit\u00e9 de Bourgogne, 7 bd Jeanne d'Arc 21033, Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM CJF 93-10, Laboratoire de Biochimie des Lipoprot\u00e9ines, Universit\u00e9 de Bourgogne, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439"]},{"raw_affiliation_string":"INSERM CJF 93-10, Laboratoire de Biochimie des Lipoprot\u00e9ines, Universit\u00e9 de Bourgogne, 7 bd Jeanne d'Arc 21033, Dijon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I177064439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043215993","display_name":"C. Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. Rodriguez","raw_affiliation_strings":["De\u0301partement de Recherches sur les Lipides et l'Athe\u0301roscle\u0301rose, Institut de Recherches Cliniques de Montreal, Montreal, Que\u0301., Canada","D\u00e9partement de Recherches sur les Lipides et l'Ath\u00e9roscl\u00e9rose, Institut de Recherches Cliniques de Montreal, Montreal, Qu\u00e9., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"De\u0301partement de Recherches sur les Lipides et l'Athe\u0301roscle\u0301rose, Institut de Recherches Cliniques de Montreal, Montreal, Que\u0301., Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"D\u00e9partement de Recherches sur les Lipides et l'Ath\u00e9roscl\u00e9rose, Institut de Recherches Cliniques de Montreal, Montreal, Qu\u00e9., Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070770963","display_name":"Jean Davignon","orcid":"https://orcid.org/0000-0002-8365-6552","observed_orcids":["https://orcid.org/0000-0002-8365-6552"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Davignon","raw_affiliation_strings":["De\u0301partement de Recherches sur les Lipides et l'Athe\u0301roscle\u0301rose, Institut de Recherches Cliniques de Montreal, Montreal, Que\u0301., Canada","D\u00e9partement de Recherches sur les Lipides et l'Ath\u00e9roscl\u00e9rose, Institut de Recherches Cliniques de Montreal, Montreal, Qu\u00e9., Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"De\u0301partement de Recherches sur les Lipides et l'Athe\u0301roscle\u0301rose, Institut de Recherches Cliniques de Montreal, Montreal, Que\u0301., Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"D\u00e9partement de Recherches sur les Lipides et l'Ath\u00e9roscl\u00e9rose, Institut de Recherches Cliniques de Montreal, Montreal, Qu\u00e9., Canada","institution_ids":["https://openalex.org/I4210158752"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":2.1006,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.86038394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"357","issue":"2","first_page":"135","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.10029999911785126,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pro-oxidant-effect","display_name":"pro-oxidant activity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/7alpha-hydroxycholesterol","display_name":"7\u03b1-hydroxycholesterol","score":0.8379999995231628},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7889365553855896},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.6649428606033325},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6622917652130127},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5744866132736206},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.5503243803977966},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5387358069419861},{"id":"https://openalex.org/C2994476132","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid oxidation","level":3,"score":0.5171998739242554},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4950536787509918},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.47183114290237427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41663068532943726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39406684041023254},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.20210233330726624},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.12641069293022156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07729390263557434}],"mesh":[{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(94)01348-5","doi":"https://doi.org/10.1016/0014-5793(94)01348-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(94)01348-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2894%2901348-5","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:7805879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7805879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(94)01348-5","doi":"https://doi.org/10.1016/0014-5793(94)01348-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(94)01348-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2894%2901348-5","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005353094.pdf","grobid_xml":"https://content.openalex.org/works/W2005353094.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1499573413","https://openalex.org/W1775749144","https://openalex.org/W1830912132","https://openalex.org/W1967587270","https://openalex.org/W1968489330","https://openalex.org/W1973107455","https://openalex.org/W1995889718","https://openalex.org/W1997745709","https://openalex.org/W2007674547","https://openalex.org/W2029135793","https://openalex.org/W2045938742","https://openalex.org/W2047309412","https://openalex.org/W2056772818","https://openalex.org/W2103612866","https://openalex.org/W2144230929","https://openalex.org/W2147908356","https://openalex.org/W2154760942","https://openalex.org/W2212323528","https://openalex.org/W2263089270","https://openalex.org/W2332207770","https://openalex.org/W2407038168","https://openalex.org/W3022864527","https://openalex.org/W4232704971"],"related_works":["https://openalex.org/W2093247636","https://openalex.org/W2076847895","https://openalex.org/W2029135793","https://openalex.org/W2339899624","https://openalex.org/W2407038168","https://openalex.org/W2415375398","https://openalex.org/W1988192085","https://openalex.org/W1834906675","https://openalex.org/W4253462108","https://openalex.org/W2038496934"],"abstract_inverted_index":{"In":[0],"low":[1],"density":[2],"lipoproteins":[3],"(LDL)":[4],"supplemented":[5],"with":[6,26],"aged":[7,38],"cholesterol":[8,39,83],"and":[9,40],"oxidized":[10],"in":[11,89],"the":[12,19,45,52,60,64,79,90],"presence":[13],"of":[14,18,55,92],"Cu2+,":[15],"an":[16],"increase":[17],"lipid":[20,81],"oxidation":[21],"parameters":[22],"was":[23],"observed":[24],"compared":[25],"pure":[27],"cholesterol-enriched":[28],"LDL.":[29],"A":[30],"compound,":[31],"identified":[32],"as":[33],"7-hydroperoxycholesterol":[34],"(7HPC),":[35],"isolated":[36],"from":[37],"added":[41],"to":[42,95],"LDL,":[43],"reproduced":[44],"above":[46],"effects.":[47],"The":[48],"results":[49],"indicate":[50],"that":[51,77],"pro-oxidant":[53],"effect":[54],"7HPC":[56],"is":[57],"dependent":[58],"on":[59],"hydroperoxy":[61],"group":[62],"since":[63],"corresponding":[65],"alcohol":[66],"derivative,":[67],"7":[68],"alpha-hydroxycholesterol,":[69],"had":[70],"no":[71],"such":[72],"effect.":[73],"These":[74],"data":[75],"suggest":[76],"among":[78],"LDL-associated":[80],"peroxides,":[82],"peroxides":[84],"may":[85],"have":[86],"important":[87],"implications":[88],"susceptibility":[91],"this":[93],"lipoprotein":[94],"oxidation.":[96]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}