{"id":"https://openalex.org/W2005350164","doi":"https://doi.org/10.1021/jp203695t","title":"Influence of Solvent and Intramolecular Hydrogen Bonding on the Conformational Properties of O-Linked Glycopeptides","display_name":"Influence of Solvent and Intramolecular Hydrogen Bonding on the Conformational Properties of O-Linked Glycopeptides","publication_year":2011,"publication_date":"2011-08-08","ids":{"openalex":"https://openalex.org/W2005350164","doi":"https://doi.org/10.1021/jp203695t","mag":"2005350164","pmid":"https://pubmed.ncbi.nlm.nih.gov/21823626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3179525"},"language":"en","primary_location":{"id":"doi:10.1021/jp203695t","doi":"https://doi.org/10.1021/jp203695t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp203695t","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3179525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086525705","display_name":"Sairam Swaroop Mallajosyula","orcid":"https://orcid.org/0000-0002-6825-0378","observed_orcids":["https://orcid.org/0000-0002-6825-0378"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sairam S. Mallajosyula","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland, 20 Penn Street HSF II, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland, 20 Penn Street HSF II, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056944006","display_name":"Alexander D. MacKerell","orcid":"https://orcid.org/0000-0001-8287-6804","observed_orcids":["https://orcid.org/0000-0001-8287-6804","https://orcid.org/0000-0003-4290-182X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander D. MacKerell","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Maryland, 20 Penn Street HSF II, Baltimore, Maryland 21201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Maryland, 20 Penn Street HSF II, Baltimore, Maryland 21201, United States","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056944006"],"corresponding_institution_ids":["https://openalex.org/I126744593"],"apc_list":null,"apc_paid":null,"fwci":1.9458,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.85568011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"115","issue":"38","first_page":"11215","last_page":"11229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.3337000012397766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.18240000307559967,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-linked-glycopeptides","display_name":"O-linked glycopeptides","score":0.9649999737739563},{"id":"https://openalex.org/keywords/o-glycosidic-linkage","display_name":"O-glycosidic linkage","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hamiltonian-replica-exchange","display_name":"Hamiltonian replica exchange","score":0.8799999952316284},{"id":"https://openalex.org/keywords/conformational-analysis","display_name":"conformational analysis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/intramolecular-hydrogen-bonding","display_name":"intramolecular hydrogen bonding","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bridging-water","display_name":"bridging water","score":0.6840000152587891},{"id":"https://openalex.org/keywords/n-acetylgalactosamine","display_name":"N-acetylgalactosamine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/n-acetylglucosamine","display_name":"N-acetylglucosamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/d-glucose","display_name":"D-glucose","score":0.6919999718666077},{"id":"https://openalex.org/keywords/d-mannose","display_name":"D-mannose","score":0.9769999980926514},{"id":"https://openalex.org/keywords/l-fucose","display_name":"L-fucose","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serine","display_name":"serine","score":0.8100000023841858},{"id":"https://openalex.org/keywords/threonine","display_name":"threonine","score":1.0},{"id":"https://openalex.org/keywords/beta-sheet","display_name":"beta-sheet","score":0.43700000643730164},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.875},{"id":"https://openalex.org/keywords/glycoproteins","display_name":"glycoproteins","score":0.6930000185966492},{"id":"https://openalex.org/keywords/solvent-effects","display_name":"solvent effects","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8132258057594299},{"id":"https://openalex.org/C109300003","wikidata":"https://www.wikidata.org/wiki/Q4384651","display_name":"Polyproline helix","level":3,"score":0.8017593622207642},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.7688445448875427},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.6748690009117126},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6482669711112976},{"id":"https://openalex.org/C150487720","wikidata":"https://www.wikidata.org/wiki/Q422553","display_name":"Glycosidic bond","level":3,"score":0.5831080675125122},{"id":"https://openalex.org/C10803110","wikidata":"https://www.wikidata.org/wiki/Q1341441","display_name":"Force field (fiction)","level":2,"score":0.5459595322608948},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.48889175057411194},{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.4453340172767639},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3811075687408447},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.37830209732055664},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.36046862602233887},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34495699405670166},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3346913754940033},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3294166028499603},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1834532916545868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09102049469947815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jp203695t","doi":"https://doi.org/10.1021/jp203695t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp203695t","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:21823626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21823626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2451540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3179525","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3179525","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3179525","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Phys Chem B","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2451540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3179525","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.8399999737739563}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5679312809","display_name":null,"funder_award_id":"GM070855","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7869237891","display_name":"Carbohydrate force fields for structure, dynamics and molecular recognition","funder_award_id":"R01GM070855","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W1820745","https://openalex.org/W614018474","https://openalex.org/W659180892","https://openalex.org/W980313740","https://openalex.org/W1555676874","https://openalex.org/W1578237164","https://openalex.org/W1671460938","https://openalex.org/W1820870565","https://openalex.org/W1964790572","https://openalex.org/W1969017401","https://openalex.org/W1969438932","https://openalex.org/W1969505913","https://openalex.org/W1970662326","https://openalex.org/W1973016225","https://openalex.org/W1973845957","https://openalex.org/W1975456619","https://openalex.org/W1975945758","https://openalex.org/W1976499671","https://openalex.org/W1981338975","https://openalex.org/W1982782097","https://openalex.org/W1989322076","https://openalex.org/W1995152253","https://openalex.org/W1995992973","https://openalex.org/W2000702472","https://openalex.org/W2004513911","https://openalex.org/W2005581828","https://openalex.org/W2006581492","https://openalex.org/W2006850107","https://openalex.org/W2007763435","https://openalex.org/W2013145865","https://openalex.org/W2017196167","https://openalex.org/W2017568541","https://openalex.org/W2019539753","https://openalex.org/W2021520922","https://openalex.org/W2021760309","https://openalex.org/W2027177034","https://openalex.org/W2027408247","https://openalex.org/W2028415968","https://openalex.org/W2031484273","https://openalex.org/W2032897045","https://openalex.org/W2033037176","https://openalex.org/W2034072732","https://openalex.org/W2035307930","https://openalex.org/W2035460800","https://openalex.org/W2038758364","https://openalex.org/W2040485478","https://openalex.org/W2040809566","https://openalex.org/W2047038103","https://openalex.org/W2048212725","https://openalex.org/W2049827814","https://openalex.org/W2050333027","https://openalex.org/W2051139617","https://openalex.org/W2051532262","https://openalex.org/W2055186032","https://openalex.org/W2056090070","https://openalex.org/W2057589234","https://openalex.org/W2059463192","https://openalex.org/W2061144516","https://openalex.org/W2064944992","https://openalex.org/W2067174909","https://openalex.org/W2069262457","https://openalex.org/W2070813875","https://openalex.org/W2075517407","https://openalex.org/W2077306479","https://openalex.org/W2077448832","https://openalex.org/W2085677500","https://openalex.org/W2086550655","https://openalex.org/W2088129724","https://openalex.org/W2094784562","https://openalex.org/W2096469227","https://openalex.org/W2098610321","https://openalex.org/W2101874060","https://openalex.org/W2102178590","https://openalex.org/W2103815459","https://openalex.org/W2106140689","https://openalex.org/W2113403117","https://openalex.org/W2115339329","https://openalex.org/W2117398821","https://openalex.org/W2117672117","https://openalex.org/W2119388326","https://openalex.org/W2119921534","https://openalex.org/W2128708864","https://openalex.org/W2130479394","https://openalex.org/W2130650699","https://openalex.org/W2132262459","https://openalex.org/W2133681472","https://openalex.org/W2138554443","https://openalex.org/W2143404508","https://openalex.org/W2146942655","https://openalex.org/W2150675831","https://openalex.org/W2153423854","https://openalex.org/W2158636430","https://openalex.org/W2158684996","https://openalex.org/W2159062378","https://openalex.org/W2178040892","https://openalex.org/W2319445814","https://openalex.org/W2338266679","https://openalex.org/W2407803547","https://openalex.org/W2949867270","https://openalex.org/W4251685699"],"related_works":["https://openalex.org/W2930378523","https://openalex.org/W2047038103","https://openalex.org/W1992288617","https://openalex.org/W2032897045","https://openalex.org/W2066375534","https://openalex.org/W1241915695","https://openalex.org/W1997223160","https://openalex.org/W1521214092","https://openalex.org/W2055186032","https://openalex.org/W1980661614"],"abstract_inverted_index":{"A":[0],"detailed":[1],"investigation":[2],"of":[3,7,71,126,136,201],"the":[4,9,15,23,38,53,68,72,95,134,137,142,154,182,193,199],"conformational":[5,190],"properties":[6],"all":[8],"biologically":[10,34],"relevant":[11,35],"O-glycosidic":[12],"linkages":[13],"using":[14],"Hamiltonian":[16],"replica":[17],"exchange":[18],"(HREX)":[19],"simulation":[20,69],"methodology":[21],"and":[22,49,52,57,83,105,119,129,147,169,176],"recently":[24],"developed":[25,160,184],"CHARMM":[26],"carbohydrate":[27],"force":[28,62,96],"field":[29,63,97],"parameters":[30,161,185],"is":[31],"presented.":[32],"Fourteen":[33],"O-linkages":[36,143],"between":[37,173],"five":[39],"sugars":[40,175],"N-acetylgalactosamine":[41],"(GalNAc),":[42],"N-acetylglucosamine":[43],"(GlcNAc),":[44],"D-glucose":[45],"(Glc),":[46],"D-mannose":[47],"(Man),":[48],"L-fucose":[50],"(Fuc)":[51],"amino":[54],"acids":[55],"serine":[56],"threonine":[58],"were":[59,162],"studied.":[60],"The":[61,92,158],"was":[64],"tested":[65],"by":[66],"comparing":[67],"results":[70,93,179],"model":[73],"glycopeptides":[74],"to":[75,98,165,195],"various":[76],"NMR":[77,203],"(3)J":[78],"coupling":[79],"constants,":[80],"NOE":[81],"distances,":[82],"data":[84],"from":[85],"molecular":[86],"dynamics":[87],"with":[88,103,141,188],"time-averaged":[89],"restraints":[90],"(tar-MD).":[91],"show":[94],"be":[99],"in":[100,186,198],"overall":[101],"agreement":[102],"experimental":[104],"previous":[106],"tar-MD":[107],"simulations,":[108],"although":[109],"some":[110],"small":[111],"limitations":[112],"are":[113],"identified.":[114],"An":[115],"in-depth":[116],"hydrogen":[117,127,167],"bond":[118],"bridging":[120],"water":[121,131,170],"analysis":[122],"revealed":[123],"an":[124],"interplay":[125],"bonding":[128,168],"bridge":[130],"interactions":[132,172],"influencing":[133],"geometry":[135],"underlying":[138],"peptide":[139],"backbone,":[140],"favoring":[144],"extended":[145],"\u03b2-sheet":[146],"polyproline":[148],"type":[149],"II":[150],"(PPII)":[151],"conformations":[152],"over":[153],"compact":[155],"\u03b1(R)-helical":[156],"conformation.":[157],"newly":[159,183],"also":[163],"able":[164],"identify":[166],"mediated":[171],"O-linked":[174],"proteins.":[177],"These":[178],"indicate":[180],"that":[181],"tandem":[187],"HREX":[189],"sampling":[191],"provide":[192],"means":[194],"study":[196],"glycoproteins":[197],"absence":[200],"targeted":[202],"restraint":[204],"data.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}