{"id":"https://openalex.org/W2005347827","doi":"https://doi.org/10.1246/cl.2009.100","title":"Synthesis of Melatonin Receptor Agonist Ramelteon via Rh-catalyzed Asymmetric Hydrogenation of an Allylamine","display_name":"Synthesis of Melatonin Receptor Agonist Ramelteon via Rh-catalyzed Asymmetric Hydrogenation of an Allylamine","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2005347827","doi":"https://doi.org/10.1246/cl.2009.100","mag":"2005347827"},"language":"en","primary_location":{"id":"doi:10.1246/cl.2009.100","doi":"https://doi.org/10.1246/cl.2009.100","is_oa":false,"landing_page_url":"https://doi.org/10.1246/cl.2009.100","pdf_url":null,"source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010952206","display_name":"Masayuki Yamashita","orcid":"https://orcid.org/0000-0001-9459-4329","observed_orcids":["https://orcid.org/0000-0001-9459-4329"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Yamashita","raw_affiliation_strings":["Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110091620","display_name":"Toru Yamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Yamano","raw_affiliation_strings":["Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd","institution_ids":["https://openalex.org/I44892455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I44892455"],"apc_list":{"value":150000,"currency":"JPY","value_usd":1003},"apc_paid":null,"fwci":1.5154,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.82383924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"38","issue":"1","first_page":"100","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11281","display_name":"Asymmetric Hydrogenation and Catalysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12240","display_name":"Nanomaterials for catalytic reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ramelteon","display_name":"ramelteon","score":0.9909999966621399},{"id":"https://openalex.org/keywords/melatonin-receptor-agonists","display_name":"melatonin receptor agonists","score":0.9419999718666077},{"id":"https://openalex.org/keywords/rhodium-catalysis","display_name":"rhodium catalysis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/asymmetric-hydrogenation","display_name":"asymmetric hydrogenation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allylamine","display_name":"allylamine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9417448043823242},{"id":"https://openalex.org/C2778927588","wikidata":"https://www.wikidata.org/wiki/Q417414","display_name":"Allylamine","level":4,"score":0.7907392978668213},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7785317301750183},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6867890954017639},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.6495610475540161},{"id":"https://openalex.org/C521398313","wikidata":"https://www.wikidata.org/wiki/Q1087","display_name":"Rhodium","level":3,"score":0.5048201680183411},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45774146914482117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37354639172554016},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2711358070373535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13592368364334106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1215600073337555},{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.0516015887260437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1246/cl.2009.100","doi":"https://doi.org/10.1246/cl.2009.100","is_oa":false,"landing_page_url":"https://doi.org/10.1246/cl.2009.100","pdf_url":null,"source":{"id":"https://openalex.org/S90825563","display_name":"Chemistry Letters","issn_l":"0366-7022","issn":["0366-7022","1348-0715"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1977034143","https://openalex.org/W2004787393","https://openalex.org/W2025478304","https://openalex.org/W2037447120","https://openalex.org/W2048701536","https://openalex.org/W2048925968","https://openalex.org/W2053238684","https://openalex.org/W2053502432","https://openalex.org/W2060592359","https://openalex.org/W2079499989","https://openalex.org/W2092128460","https://openalex.org/W2097446202","https://openalex.org/W2107692241","https://openalex.org/W2115132894","https://openalex.org/W2143568619","https://openalex.org/W2151262921","https://openalex.org/W2521585712","https://openalex.org/W2826868156","https://openalex.org/W2949840789","https://openalex.org/W2950562327","https://openalex.org/W2950971696","https://openalex.org/W2951735771"],"related_works":["https://openalex.org/W2950860316","https://openalex.org/W2048701536","https://openalex.org/W2000055674","https://openalex.org/W1971547736","https://openalex.org/W2952802904","https://openalex.org/W3204774573","https://openalex.org/W2048448923","https://openalex.org/W2129615524","https://openalex.org/W1999508656","https://openalex.org/W4405194417"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"the":[2,11,33],"course":[3],"of":[4,32],"developing":[5],"a":[6,18],"practical":[7],"synthetic":[8],"method":[9],"for":[10,29],"selective":[12],"melatonin":[13],"MT1/MT2":[14],"receptor":[15],"agonist":[16],"Ramelteon,":[17],"rhodium":[19],"Josiphos":[20],"complex":[21],"was":[22],"found":[23],"to":[24],"be":[25],"an":[26],"excellent":[27],"catalyst":[28],"asymmetric":[30],"hydrogenation":[31],"key":[34],"precursor,":[35],"allylamine":[36],"1.":[37]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}