{"id":"https://openalex.org/W2005345082","doi":"https://doi.org/10.1097/00002030-199306000-00010","title":"Recombinant \u03b1-interferon 2b in the treatment of HIV-related thrombocytopenia","display_name":"Recombinant \u03b1-interferon 2b in the treatment of HIV-related thrombocytopenia","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2005345082","doi":"https://doi.org/10.1097/00002030-199306000-00010","mag":"2005345082","pmid":"https://pubmed.ncbi.nlm.nih.gov/8363758"},"language":"en","primary_location":{"id":"doi:10.1097/00002030-199306000-00010","doi":"https://doi.org/10.1097/00002030-199306000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002030-199306000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045651843","display_name":"Nicola Vianelli","orcid":"https://orcid.org/0000-0001-5886-036X","observed_orcids":["https://orcid.org/0000-0001-5886-036X"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Vianelli","raw_affiliation_strings":["Institute of Haematology, S. Orsola Hospital, Bologna, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Haematology, S. Orsola Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085994414","display_name":"Lucia Catani","orcid":"https://orcid.org/0000-0002-4650-201X","observed_orcids":["https://orcid.org/0000-0002-4650-201X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Catani","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110626724","display_name":"Luigi Gugliotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Gugliotta","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050874861","display_name":"Monica Mattioli\u2010Belmonte","orcid":"https://orcid.org/0000-0002-2087-2776","observed_orcids":["https://orcid.org/0000-0002-2087-2776"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Mattioli Belmonte","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Loredana Cascione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Loredana Cascione","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048376546","display_name":"Vincenzo Colangeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Colangeli","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113600480","display_name":"E Ricchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Ricchi","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109353289","display_name":"Patrizio Mazza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizio Mazza","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109352690","display_name":"Maria Gabriella Mazzucconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Gabriella Mazzucconi","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087623314","display_name":"Antonio Chistolini","orcid":"https://orcid.org/0000-0002-2593-1376","observed_orcids":["https://orcid.org/0000-0002-2593-1376"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Chistolini","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035668458","display_name":"Gian Paolo Bagnara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian Paolo Bagnara","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112050858","display_name":"Sante Tura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sante Tura","raw_affiliation_strings":["La Sapienza\u2019, Roma, Italy","\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"\u2018L. e A. Ser\u00e0gnoli\u2019 Institute of Hematology, the Institute of Infectious Disease, the Institute of Histology Centre Interdipartimentale per la Ricerca sul Cancro G. Prodi, University of Bologna and the Haematology and Biopathology Departments, University \u2018La Sapienza\u2019, Roma, Italy","institution_ids":["https://openalex.org/I861853513","https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.194,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76364496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"6","first_page":"823","last_page":"828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-survival","display_name":"platelet survival","score":0.8740000128746033},{"id":"https://openalex.org/keywords/platelet-turnover","display_name":"platelet turnover","score":0.9399999976158142},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7009999752044678},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.7020000219345093},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7945436239242554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7748944163322449},{"id":"https://openalex.org/C2779705218","wikidata":"https://www.wikidata.org/wiki/Q821701","display_name":"Megakaryocyte","level":4,"score":0.7475031614303589},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5677947998046875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5553283095359802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5244284272193909},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5230377912521362},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4688148498535156},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4562346935272217},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4237349033355713},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21968421339988708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13444176316261292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000386","descriptor_name":"AIDS-Related Complex","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000386","descriptor_name":"AIDS-Related Complex","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016553","descriptor_name":"Purpura, Thrombocytopenic, Idiopathic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1097/00002030-199306000-00010","doi":"https://doi.org/10.1097/00002030-199306000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00002030-199306000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:8363758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8363758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/915168","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11585/915168","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/89111","doi":null,"is_oa":false,"landing_page_url":"http://www.ncbi.nlm.nih.gov/pubmed/8363758","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.univpm.it:11566/73305","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/73305","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115237263","https://openalex.org/W2042509526","https://openalex.org/W2052701293","https://openalex.org/W2373890555","https://openalex.org/W2436570949","https://openalex.org/W2113820039","https://openalex.org/W2039085423","https://openalex.org/W2429844850","https://openalex.org/W2054344967","https://openalex.org/W2013262166"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,6,14,150],"efficacy":[4],"and":[5,25,63,76,84,166],"mechanism":[7],"of":[8,10,16,47,93,131,169],"action":[9,168],"alpha-interferon":[11],"(alpha-IFN)":[12],"in":[13,87,153],"treatment":[15,86],"HIV-related":[17],"thrombocytopenia.":[18],"METHODS:":[19],"Thirteen":[20],"HIV-positive":[21,154],"subjects":[22,95,155],"[nine":[23],"men":[24],"four":[26],"women":[27],"with":[28,40,156],"severe":[29,157],"thrombocytopenia":[30,159],"(platelets,":[31,100],"<":[32],"or":[33],"=":[34],"30":[35],"x":[36,49,102],"10(9)/l)]":[37],"were":[38,81],"treated":[39],"alpha-IFN":[41,105,138,146],"2b":[42,106,139,147],"alone":[43],"at":[44],"a":[45,54,97,120],"dose":[46],"3":[48],"10(6)":[50],"U":[51],"three":[52],"times":[53],"week":[55],"for":[56,175],"5":[57],"weeks.":[58],"Haematological":[59],"parameters,":[60],"platelet":[61,117,151,162,177],"kinetic":[62],"bone-marrow":[64,132],"myeloid":[65,133],"progenitor":[66,134],"cultures":[67],"[megakaryocyte":[68],"colony-forming":[69],"units":[70,79],"(CFU-MK);":[71],"granulocyte":[72],"macrophage":[73],"CFU":[74],"(CFU-GM)":[75],"erythroid":[77],"burst-forming":[78],"(BFU-E)]":[80],"evaluated":[82,111],"before":[83],"after":[85,104,127,137],"responsive":[88],"subjects.":[89],"RESULTS:":[90],"Seven":[91],"out":[92],"13":[94],"showed":[96,119],"partial":[98],"response":[99],"50-149":[101],"10(9)/l)":[103],"therapy.":[107],"Platelet":[108],"survival":[109],"as":[110],"by":[112,160],"111In-oxine":[113],"significantly":[114],"increased,":[115],"while":[116],"turnover":[118],"slight":[121],"but":[122],"not":[123],"statistically":[124],"significant":[125],"increase":[126,149],"treatment.":[128],"The":[129,164],"growth":[130],"cells":[135],"decreased":[136],"therapy,":[140],"again":[141],"without":[142],"statistical":[143],"significance.":[144],"CONCLUSION:":[145],"may":[148,172],"count":[152],"symptomatic":[158],"prolonging":[161],"survival.":[163,178],"immunomodulatory":[165],"antiviral":[167],"this":[170],"drug":[171],"be":[173],"responsible":[174],"prolonged":[176]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
