{"id":"https://openalex.org/W2005339378","doi":"https://doi.org/10.1016/j.clineuro.2013.02.025","title":"Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients","display_name":"Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients","publication_year":2013,"publication_date":"2013-03-21","ids":{"openalex":"https://openalex.org/W2005339378","doi":"https://doi.org/10.1016/j.clineuro.2013.02.025","mag":"2005339378","pmid":"https://pubmed.ncbi.nlm.nih.gov/23523621"},"language":"en","primary_location":{"id":"doi:10.1016/j.clineuro.2013.02.025","doi":"https://doi.org/10.1016/j.clineuro.2013.02.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clineuro.2013.02.025","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091865646","display_name":"Najiba Fekih\u2010Mrissa","orcid":"https://orcid.org/0000-0003-3485-5237","observed_orcids":["https://orcid.org/0000-0003-3485-5237"]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Najiba Fekih Mrissa","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia. fnajiba@yahoo.fr","Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia. fnajiba@yahoo.fr","institution_ids":["https://openalex.org/I4210155821"]},{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004453379","display_name":"Meriem Mrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Meriem Mrad","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026506839","display_name":"Sarra Klai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Sarra Klai","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074773633","display_name":"Jamel Zaouali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Jamel Zaouali","raw_affiliation_strings":["Department of Neurology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aycha Sayeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Aycha Sayeh","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065286688","display_name":"Chakib Mazigh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Chakib Mazigh","raw_affiliation_strings":["Department of Biochemistry, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110187158","display_name":"Brahim Nsiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Brahim Nsiri","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063166110","display_name":"Salem Machgoul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Salem Machgoul","raw_affiliation_strings":["Department of Biochemistry, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035183922","display_name":"Nasreddine Gritli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Nasreddine Gritli","raw_affiliation_strings":["Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045487376","display_name":"Ridha Mrissa","orcid":"https://orcid.org/0000-0002-2023-5486","observed_orcids":["https://orcid.org/0000-0002-2023-5486"]},"institutions":[{"id":"https://openalex.org/I4210155821","display_name":"Military Hospital of Tunis","ror":"https://ror.org/04n4f3r80","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210155821"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ridha Mrissa","raw_affiliation_strings":["Department of Neurology, Military Hospital of Tunisia, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Military Hospital of Tunisia, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210155821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091865646"],"corresponding_institution_ids":["https://openalex.org/I4210155821"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.9625,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.73901356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"115","issue":"9","first_page":"1657","last_page":"1660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7871000170707703,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7871000170707703,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.20579999685287476,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/methylenetetrahydrofolate-reductase","display_name":"methylenetetrahydrofolate reductase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mthfr-a1298c-polymorphism","display_name":"MTHFR A1298C polymorphism","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tunisian-patients","display_name":"Tunisian patients","score":0.8880000114440918},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9850901365280151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8112886548042297},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7532616257667542},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7061160206794739},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.6516209840774536},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5460909605026245},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4471370577812195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42579013109207153},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31389546394348145},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24679243564605713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20621293783187866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08888515830039978},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.06131020188331604}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.clineuro.2013.02.025","doi":"https://doi.org/10.1016/j.clineuro.2013.02.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.clineuro.2013.02.025","pdf_url":null,"source":{"id":"https://openalex.org/S165396890","display_name":"Clinical Neurology and Neurosurgery","issn_l":"0303-8467","issn":["0303-8467","1872-6968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neurology and Neurosurgery","raw_type":"journal-article"},{"id":"pmid:23523621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23523621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neurology and neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1560343627","https://openalex.org/W1966251853","https://openalex.org/W1969078199","https://openalex.org/W1980284325","https://openalex.org/W1994735079","https://openalex.org/W2009205577","https://openalex.org/W2011089854","https://openalex.org/W2026663403","https://openalex.org/W2031262735","https://openalex.org/W2065898469","https://openalex.org/W2088072554","https://openalex.org/W2103085707","https://openalex.org/W2103649136","https://openalex.org/W2103922885","https://openalex.org/W2105548401","https://openalex.org/W2114909340","https://openalex.org/W2122545833","https://openalex.org/W2126230337","https://openalex.org/W2131205634","https://openalex.org/W2146934684","https://openalex.org/W2158138637","https://openalex.org/W2161929126","https://openalex.org/W2165715420","https://openalex.org/W2617895008","https://openalex.org/W2916040650","https://openalex.org/W4229932900","https://openalex.org/W4230052474"],"related_works":["https://openalex.org/W2011089854","https://openalex.org/W2938481812","https://openalex.org/W4417431175","https://openalex.org/W1878788353","https://openalex.org/W2347023637","https://openalex.org/W2089279295","https://openalex.org/W7096729875","https://openalex.org/W844814884","https://openalex.org/W4413857757","https://openalex.org/W2065898469"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
