{"id":"https://openalex.org/W2005339350","doi":"https://doi.org/10.1161/hc3801.095662","title":"c-Jun Decreases Voltage-Gated K + Channel Activity in Pulmonary Artery Smooth Muscle Cells","display_name":"c-Jun Decreases Voltage-Gated K + Channel Activity in Pulmonary Artery Smooth Muscle Cells","publication_year":2001,"publication_date":"2001-09-25","ids":{"openalex":"https://openalex.org/W2005339350","doi":"https://doi.org/10.1161/hc3801.095662","mag":"2005339350","pmid":"https://pubmed.ncbi.nlm.nih.gov/11571252"},"language":"en","primary_location":{"id":"doi:10.1161/hc3801.095662","doi":"https://doi.org/10.1161/hc3801.095662","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hc3801.095662","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/hc3801.095662","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2005339350"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/hc3801.095662","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101767295","display_name":"Ying Yu","orcid":"https://orcid.org/0000-0003-2427-0411","observed_orcids":["https://orcid.org/0000-0003-2427-0411","https://orcid.org/0009-0001-2322-5718"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Yu","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003629788","display_name":"Oleksandr Platoshyn","orcid":"https://orcid.org/0000-0001-6529-6752","observed_orcids":["https://orcid.org/0000-0001-6529-6752"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleksandr Platoshyn","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784047","display_name":"Jifeng Zhang","orcid":"https://orcid.org/0000-0003-3926-3468","observed_orcids":["https://orcid.org/0000-0003-3926-3468"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jifeng Zhang","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020903748","display_name":"Stefanie Krick","orcid":"https://orcid.org/0000-0002-8284-6768","observed_orcids":["https://orcid.org/0000-0002-8284-6768"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefanie Krick","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069683490","display_name":"Ying Zhao","orcid":"https://orcid.org/0000-0003-2232-8026","observed_orcids":["https://orcid.org/0000-0003-2232-8026"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Zhao","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006434846","display_name":"Lewis J. Rubin","orcid":"https://orcid.org/0000-0002-4952-5786","observed_orcids":["https://orcid.org/0000-0002-4952-5786"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lewis J. Rubin","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042892814","display_name":"Abraham Rothman","orcid":"https://orcid.org/0000-0002-7092-5784","observed_orcids":["https://orcid.org/0000-0002-7092-5784"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Rothman","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108752705","display_name":"Jason X.\u2010J. Yuan","orcid":"https://orcid.org/0000-0002-0685-4862","observed_orcids":["https://orcid.org/0000-0002-0685-4862"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason X.-J. Yuan","raw_affiliation_strings":["From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine (Y.Y., O.P., S.K., Y.Z., L.J.R., J.X.-J.Y.) and Pediatrics (J.Z., A.R.), University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108752705"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.385,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.50624508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"104","issue":"13","first_page":"1557","last_page":"1563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.1436000019311905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.9950000047683716},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/kv1-5","display_name":"Kv1.5","score":0.9879999756813049},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.8600000143051147},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.890999972820282},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.9660000205039978},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.6940000057220459},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8483995199203491},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.5370607972145081},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.5302051305770874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35476768016815186},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33141785860061646},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32917964458465576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016755","descriptor_name":"Proto-Oncogene Proteins c-jun","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/hc3801.095662","doi":"https://doi.org/10.1161/hc3801.095662","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hc3801.095662","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/hc3801.095662","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:11571252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11571252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1000.2301","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1000.2301","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/104/13/1557.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.545.3956","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.545.3956","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/104/13/1557.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/hc3801.095662","doi":"https://doi.org/10.1161/hc3801.095662","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hc3801.095662","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/hc3801.095662","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426602300","display_name":null,"funder_award_id":"HL 54043","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G723327440","display_name":null,"funder_award_id":"HL 64549","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2005339350.pdf","grobid_xml":"https://content.openalex.org/works/W2005339350.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W134363133","https://openalex.org/W1535875327","https://openalex.org/W1753089048","https://openalex.org/W1889047426","https://openalex.org/W1963652804","https://openalex.org/W1980619986","https://openalex.org/W1983059448","https://openalex.org/W1991668646","https://openalex.org/W1995745389","https://openalex.org/W2014609720","https://openalex.org/W2016417151","https://openalex.org/W2021858120","https://openalex.org/W2034126125","https://openalex.org/W2036224418","https://openalex.org/W2071140879","https://openalex.org/W2072240092","https://openalex.org/W2074563618","https://openalex.org/W2076159874","https://openalex.org/W2081136116","https://openalex.org/W2089742414","https://openalex.org/W2094182857","https://openalex.org/W2124462138","https://openalex.org/W2155920800","https://openalex.org/W2166431337","https://openalex.org/W2181344473","https://openalex.org/W2181526959","https://openalex.org/W2182408657","https://openalex.org/W2184358523","https://openalex.org/W2266973650","https://openalex.org/W2335815721","https://openalex.org/W2410077164","https://openalex.org/W2473762969"],"related_works":["https://openalex.org/W2266973650","https://openalex.org/W2124462138","https://openalex.org/W2052716105","https://openalex.org/W2016417151","https://openalex.org/W2146411024","https://openalex.org/W4231339955","https://openalex.org/W2015924396","https://openalex.org/W2014609720","https://openalex.org/W2103424889","https://openalex.org/W2015281632"],"abstract_inverted_index":{"BACKGROUND:":[0],"Activity":[1],"of":[2,62,76,104,110,129,135],"voltage-gated":[3],"K(+)":[4],"(K(v))":[5],"channels":[6],"controls":[7],"membrane":[8,183],"potential":[9],"(E(m))":[10],"that":[11,46,100,170],"regulates":[12],"cytosolic":[13],"free":[14],"Ca(2+)":[15,21],"concentration":[16],"([Ca(2+)](cyt))":[17],"by":[18],"regulating":[19],"voltage-dependent":[20],"channel":[22,52],"function.":[23],"A":[24],"rise":[25],"in":[26,28,54,115,151,157,179],"[Ca(2+)](cyt)":[27,186],"pulmonary":[29],"artery":[30],"smooth":[31],"muscle":[32],"cells":[33,86,121,123,159,161],"(PASMCs)":[34],"triggers":[35],"vasoconstriction":[36],"and":[37,78,106,122,137,146,160,187],"stimulates":[38,47],"PASMC":[39,172,189],"proliferation.":[40],"Whether":[41],"c-Jun,":[42],"a":[43,177],"transcription":[44],"factor":[45],"cell":[48],"proliferation,":[49],"affects":[50],"K(v)":[51,80],"activity":[53],"PASMCs":[55,65,117,152],"was":[56,143,149],"investigated.":[57],"METHODS":[58],"AND":[59],"RESULTS:":[60],"Infection":[61],"primary":[63],"cultured":[64],"with":[66,84,88,119,125,154,163,176],"an":[67,89],"adenoviral":[68],"vector":[69],"expressing":[70],"c-jun":[71,155],"increased":[72],"the":[73,101,107],"protein":[74,133],"level":[75,103],"c-Jun":[77,130],"reduced":[79],"currents":[81],"(I(K(V)))":[82],"compared":[83,118],"control":[85,120,158],"(infected":[87],"empty":[90],"adenovirus).":[91],"Using":[92],"single-cell":[93],"reverse":[94],"transcription-polymerase":[95],"chain":[96],"reaction,":[97],"we":[98],"observed":[99],"mRNA":[102],"Kv1.5":[105],"current":[108],"density":[109],"I(K(V))":[111,139],"were":[112],"both":[113],"attenuated":[114],"c-jun-infected":[116],"infected":[124,153,162],"antisense":[126,164],"c-jun.":[127,165],"Overexpression":[128],"also":[131],"upregulated":[132],"expression":[134],"Kvbeta(2)":[136],"accelerated":[138],"inactivation.":[140],"Furthermore,":[141],"E(m)":[142],"more":[144],"depolarized":[145],"[(3)H]thymidine":[147],"incorporation":[148],"greater":[150],"than":[156],"CONCLUSIONS:":[166],"These":[167],"results":[168],"suggest":[169],"c-Jun-mediated":[171],"proliferation":[173],"is":[174],"associated":[175],"decrease":[178],"I(K(V)).":[180],"The":[181],"resultant":[182],"depolarization":[184],"increases":[185],"enhances":[188],"growth.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}