{"id":"https://openalex.org/W2005338270","doi":"https://doi.org/10.1242/bio.20135090","title":"Interactions between the discoidin domain receptor 1 and \u03b21 integrin regulate attachment to collagen","display_name":"Interactions between the discoidin domain receptor 1 and \u03b21 integrin regulate attachment to collagen","publication_year":2013,"publication_date":"2013-09-13","ids":{"openalex":"https://openalex.org/W2005338270","doi":"https://doi.org/10.1242/bio.20135090","mag":"2005338270","pmid":"https://pubmed.ncbi.nlm.nih.gov/24244851"},"language":"en","primary_location":{"id":"doi:10.1242/bio.20135090","doi":"https://doi.org/10.1242/bio.20135090","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.20135090","pdf_url":null,"source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1242/bio.20135090","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049304828","display_name":"Lisa A. Staudinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lisa A. Staudinger","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063135972","display_name":"Stephen J. Spano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephen J. Spano","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wilson Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wilson Lee","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053062012","display_name":"Nuno M. Coelho","orcid":"https://orcid.org/0000-0001-7128-1362","observed_orcids":["https://orcid.org/0000-0001-7128-1362"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nuno Coelho","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025495845","display_name":"Dhaarmini Rajshankar","orcid":"https://orcid.org/0000-0001-7155-8739","observed_orcids":["https://orcid.org/0000-0001-7155-8739"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dhaarmini Rajshankar","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052703872","display_name":"Michelle Patricia Bendeck","orcid":"https://orcid.org/0000-0002-9140-8508","observed_orcids":["https://orcid.org/0000-0002-9140-8508"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michelle P. Bendeck","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057346145","display_name":"Tara J. Moriarty","orcid":"https://orcid.org/0000-0002-1751-5145","observed_orcids":["https://orcid.org/0000-0002-1751-5145"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tara Moriarty","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051002562","display_name":"Christopher A. McCulloch","orcid":"https://orcid.org/0000-0002-3535-8593","observed_orcids":["https://orcid.org/0000-0002-3535-8593"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher A. McCulloch","raw_affiliation_strings":["Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, M5S 3E2, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185261750"],"apc_list":{"value":1995,"currency":"USD","value_usd":1995},"apc_paid":{"value":1995,"currency":"USD","value_usd":1995},"fwci":5.2864,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.95120398,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"11","first_page":"1148","last_page":"1159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ddr1","display_name":"DDR1","score":0.9459999799728394},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/collagen-phagocytosis","display_name":"collagen phagocytosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/collagen-remodeling","display_name":"collagen remodeling","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6269999742507935},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.8899999856948853},{"id":"https://openalex.org/keywords/jararhagin","display_name":"jararhagin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/deoxymannojirimycin","display_name":"deoxymannojirimycin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/collagen-binding","display_name":"collagen binding","score":0.6909999847412109},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C152681006","wikidata":"https://www.wikidata.org/wiki/Q17854856","display_name":"DDR1","level":4,"score":0.9586261510848999},{"id":"https://openalex.org/C2776305115","wikidata":"https://www.wikidata.org/wiki/Q24727589","display_name":"Discoidin domain","level":4,"score":0.919727087020874},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.9117337465286255},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8179718255996704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6587822437286377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6113942265510559},{"id":"https://openalex.org/C4894155","wikidata":"https://www.wikidata.org/wiki/Q4201950","display_name":"CD49c","level":5,"score":0.5486444234848022},{"id":"https://openalex.org/C156585808","wikidata":"https://www.wikidata.org/wiki/Q18028043","display_name":"Integrin, beta 6","level":4,"score":0.47020918130874634},{"id":"https://openalex.org/C2777979848","wikidata":"https://www.wikidata.org/wiki/Q424042","display_name":"Vinculin","level":4,"score":0.4596613645553589},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.44230103492736816},{"id":"https://openalex.org/C182676581","wikidata":"https://www.wikidata.org/wiki/Q4201948","display_name":"CD49b","level":5,"score":0.42837631702423096},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.42317935824394226},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4056430160999298},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.35161322355270386},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2566014230251312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2463831603527069},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2333695888519287},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.20800256729125977},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.07206538319587708},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.06229165196418762},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1242/bio.20135090","doi":"https://doi.org/10.1242/bio.20135090","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.20135090","pdf_url":null,"source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},{"id":"pmid:24244851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24244851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology open","raw_type":"Journal Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/67651","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/67651","pdf_url":"https://utoronto.scholaris.ca/bitstreams/7e152533-e71f-4790-9059-28f163935f70/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2815660","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3828761","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3828761","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3828761","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biol Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5401010204bf444e9e19d56465575104","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5401010204bf444e9e19d56465575104","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Open, Vol 2, Iss 11, Pp 1148-1159 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1242/bio.20135090","doi":"https://doi.org/10.1242/bio.20135090","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.20135090","pdf_url":null,"source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W202956287","https://openalex.org/W1512465828","https://openalex.org/W1526000978","https://openalex.org/W1576773659","https://openalex.org/W1602804242","https://openalex.org/W1938033796","https://openalex.org/W1940021039","https://openalex.org/W1966296130","https://openalex.org/W1973334306","https://openalex.org/W1975317988","https://openalex.org/W1986168443","https://openalex.org/W1987406153","https://openalex.org/W1991604116","https://openalex.org/W1992043945","https://openalex.org/W1994880395","https://openalex.org/W2002054287","https://openalex.org/W2002778380","https://openalex.org/W2017145276","https://openalex.org/W2019624372","https://openalex.org/W2032392940","https://openalex.org/W2034226301","https://openalex.org/W2035048759","https://openalex.org/W2046021634","https://openalex.org/W2048503716","https://openalex.org/W2050106278","https://openalex.org/W2050742799","https://openalex.org/W2059253566","https://openalex.org/W2062136146","https://openalex.org/W2062862555","https://openalex.org/W2064047723","https://openalex.org/W2069532196","https://openalex.org/W2075753097","https://openalex.org/W2078913904","https://openalex.org/W2080520966","https://openalex.org/W2083299750","https://openalex.org/W2086657557","https://openalex.org/W2088360100","https://openalex.org/W2090196160","https://openalex.org/W2090842150","https://openalex.org/W2094389040","https://openalex.org/W2110689814","https://openalex.org/W2112442511","https://openalex.org/W2127803449","https://openalex.org/W2145449209","https://openalex.org/W2150525787","https://openalex.org/W2150647358","https://openalex.org/W2157523461","https://openalex.org/W2157748080","https://openalex.org/W2158933399","https://openalex.org/W2160073301","https://openalex.org/W2164330595","https://openalex.org/W2164490839","https://openalex.org/W2405957212","https://openalex.org/W2444181586","https://openalex.org/W3189920043","https://openalex.org/W4240746805"],"related_works":["https://openalex.org/W1971239528","https://openalex.org/W2804793284","https://openalex.org/W2789761739","https://openalex.org/W2046409949","https://openalex.org/W2322385351","https://openalex.org/W2126261790","https://openalex.org/W2092636778","https://openalex.org/W4313354036","https://openalex.org/W2005338270","https://openalex.org/W2253636548"],"abstract_inverted_index":{"Collagen":[0],"degradation":[1],"by":[2,179],"phagocytosis":[3,19,205],"is":[4,20,54],"essential":[5],"for":[6,117],"physiological":[7],"collagen":[8,89,92,96,182,204,207],"turnover":[9],"and":[10,31,59,69,87,94,111,121,155,206],"connective":[11],"tissue":[12],"homeostasis.":[13],"The":[14],"rate":[15],"limiting":[16],"step":[17,202],"of":[18,23,51,66,85,113,157,171,203],"the":[21,29,48,64,128,145,153,162,172,200],"binding":[22,93,201],"specific":[24],"adhesion":[25],"receptors,":[26],"which":[27,176,197],"include":[28],"integrins":[30],"discoidin":[32],"domain":[33],"receptors":[34,46],"(DDR),":[35],"to":[36,134,161],"fibrillar":[37,195],"collagen.":[38],"While":[39],"previous":[40],"data":[41,186],"suggest":[42],"that":[43,149,188],"these":[44,52,185],"two":[45],"interact,":[47],"functional":[49],"nature":[50],"interactions":[53,193],"not":[55],"defined.":[56],"In":[57,98],"mouse":[58],"human":[60],"fibroblasts":[61],"we":[62],"examined":[63],"effects":[65],"DDR1":[67,76,99,136,150,164,189],"knockdown":[68],"over-expression":[70,151,165],"on":[71],"\u03b21":[72,123,141,159,173,191],"integrin":[73,142,160,174,192],"subunit":[74],"function.":[75],"expression":[77],"levels":[78],"were":[79,107],"positively":[80,198],"associated":[81,167],"with":[82,103,127,168,194],"enhanced":[83],"contraction":[84],"floating":[86],"attached":[88],"gels,":[90],"increased":[91,95,108,140,169],"remodeling.":[97,208],"over-expressing":[100,137],"cells":[101,138],"compared":[102],"control":[104],"cells,":[105],"there":[106],"numbers,":[109],"area":[110],"length":[112],"focal":[114],"adhesions":[115],"immunostained":[116],"talin,":[118],"paxillin,":[119],"vinculin":[120],"activated":[122],"integrin.":[124],"After":[125],"treatment":[126],"integrin-cleaving":[129],"protease":[130],"jararhagin,":[131],"in":[132],"comparison":[133],"controls,":[135],"exhibited":[139],"cleavage":[143],"at":[144],"cell":[146],"membrane,":[147],"indicating":[148],"affected":[152],"access":[154],"susceptibility":[156],"cell-surface":[158],"protease.":[163],"was":[166],"glycosylation":[170],"subunit,":[175],"when":[177],"blocked":[178],"deoxymannojirimycin,":[180],"reduced":[181],"binding.":[183],"Collectively":[184],"indicate":[187],"regulates":[190],"collagen,":[196],"impacts":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2025-10-10T00:00:00"}